• Thumbnail for Sigma-1 receptor
    The sigma-1 receptor (σ1R), one of two sigma receptor subtypes, is a chaperone protein at the endoplasmic reticulum (ER) that modulates calcium signaling...
    34 KB (3,792 words) - 16:38, 21 May 2025
  • Sigma receptors (σ-receptors) are protein receptors that bind ligands such as 4-PPBP (4-phenyl-1-(4-phenylbutyl) piperidine), SA 4503 (cutamesine), ditolylguanidine...
    17 KB (1,832 words) - 12:09, 22 May 2025
  • Thumbnail for Sigma-2 receptor
    The sigma-2 receptor (σ2R) is a sigma receptor subtype that has attracted attention due to its involvement in diseases such as neurological diseases, neurodegenerative...
    22 KB (2,332 words) - 15:38, 28 April 2025
  • derivative of phenylpiracetam, is a positive allosteric modulator of the sigma σ1 receptor. It is currently the only racetam known to possess this action. In...
    17 KB (1,705 words) - 02:38, 22 April 2025
  • Thumbnail for List of neurosteroids
    pregn-5-en-3β-ol-20-one 3β-sulfate – GABAA receptor negative allosteric modulator, NMDA receptor positive allosteric modulator, sigma-1 receptor agonist, TRPM3 agonist,...
    19 KB (2,002 words) - 02:02, 18 May 2025
  • Thumbnail for Methylphenylpiracetam
    Methylphenylpiracetam (category Receptor modulators)
    derivative of piracetam and a positive allosteric modulator of the sigma-1 receptor. It differs from phenylpiracetam by having a methyl group. E1R is the...
    7 KB (536 words) - 18:47, 24 May 2025
  • Thumbnail for Neurosteroid
    perspective on the new mechanism of antidepressants: neuritogenesis through sigma-1 receptors". Pharmacopsychiatry. 37 (Suppl 3): S208–13. doi:10.1055/s-2004-832679...
    42 KB (4,402 words) - 13:14, 30 March 2025
  • Thumbnail for Pridopidine
    Pridopidine (category Sigma agonists)
    molecule investigational drug. Pridopidine is a selective and potent Sigma-1 Receptor agonist. It is being developed by Prilenia Therapeutics and is currently...
    15 KB (1,571 words) - 03:24, 23 December 2024
  • Sigma (/ˈsɪɡmə/ SIG-mə; uppercase Σ, lowercase σ, lowercase in word-final position ς; Ancient Greek: σίγμα) is the eighteenth letter of the Greek alphabet...
    18 KB (2,185 words) - 02:22, 27 May 2025
  • Thumbnail for Levopropoxyphene
    as an antitussive. Unlike many antitussives, it binds poorly to the sigma-1 receptor. Friedel-Crafts acylation of benzene with propionyl chloride and aluminium...
    5 KB (318 words) - 05:04, 10 March 2025
  • Thumbnail for Fluspidine
    emission tomography (PET) scans to image σ1 (sigma-1) receptors in the brain and other tissues. Sigma-1 receptors are proteins involved in many neurological...
    6 KB (215 words) - 04:34, 23 May 2025
  • 6-tetrahydro-5-[3-(4-methylphenyl)-5-isoxazolyl]-1-propylpyridine is a potent and selective ligand for the sigma-1 receptor, with a reported binding affinity of Ki...
    2 KB (96 words) - 14:55, 17 January 2025
  • Memantine/donepezil (category NMDA receptor antagonists)
    an NMDA receptor antagonist, among various other types of targets like 5-HT3 receptor, Nicotinic acetylcholine receptor, and Sigma-1 receptor) and donepezil...
    5 KB (203 words) - 13:23, 6 May 2025
  • Thumbnail for Diproqualone
    Diproqualone (category GABAA receptor positive allosteric modulators)
    possibly its agonist activity at both the sigma-1 receptor and sigma-2 receptor (the function of these receptors and their clinical relevance has not yet...
    4 KB (236 words) - 09:07, 21 January 2025
  • MS-377 (category Sigma receptor modulators)
    selective antagonist of the sigma-1 receptor. It possesses anti-psychotic properties. MS-377 acts selectively at the sigma-1 receptor as an antagonist. It does...
    4 KB (327 words) - 21:27, 30 March 2025
  • Thumbnail for Sertraline
    Sertraline (redirect from CP 51,974-1)
    Hashimoto K (2017). "Sigma-1 Receptor Agonists and Their Clinical Implications in Neuropsychiatric Disorders". Sigma Receptors: Their Role in Disease...
    104 KB (10,669 words) - 23:02, 22 May 2025
  • Thumbnail for Opipramol
    Opipramol (category Sigma agonists)
    most other tricyclic antidepressants, and instead acts primarily as a sigma-1 receptor agonist. It was developed by Schindler and Blattner in 1961. Opipramol...
    27 KB (2,047 words) - 20:11, 24 May 2025
  • Thumbnail for Cloroqualone
    Cloroqualone (category GABAA receptor positive allosteric modulators)
    resulting from its agonist activity at the β subtype of the GABAa receptor and sigma-1 receptor, and was sold either alone or in combination with other ingredients...
    3 KB (166 words) - 15:42, 4 March 2024
  • protein, the sigma-2 receptor, found in cell membranes. It is highly selective for this over the related sigma-1 receptor. The sigma-2 receptor is significant...
    2 KB (216 words) - 21:23, 21 February 2025
  • Thumbnail for Dimethyltryptamine
    Dimethyltryptamine (category Sigma agonists)
    demonstrated the immunomodulatory potential of DMT and 5-MeO-DMT through the Sigma-1 receptor of human immune cells. This immunomodulatory activity may contribute...
    174 KB (16,813 words) - 02:49, 27 May 2025
  • intracellular receptors that promote monoamine neurotransmission. For instance, methamphetamine acts as an agonist of sigma-1 receptor. ATS use disorders...
    23 KB (2,404 words) - 22:09, 23 May 2025
  • alpha-1 (α1) adrenergic are G protein-coupled receptors (GPCRs) associated with the Gq heterotrimeric G protein. α1-adrenergic receptors are subdivided...
    16 KB (1,527 words) - 14:51, 25 May 2025
  • Thumbnail for Psychoactive drug
    their primary neurotransmitter, receptor or method of action. Many drugs act on more than one transmitter or receptor in the brain. Psychoactive drugs...
    83 KB (8,221 words) - 08:39, 24 May 2025
  • Thumbnail for Dextromethorphan
    reuptake inhibitor and a sigma-1 receptor agonist. Dextromethorphan and its major metabolite, dextrorphan, also block the NMDA receptor at high doses, which...
    51 KB (4,638 words) - 04:16, 12 May 2025
  • Thumbnail for Pierre Jean Robiquet
    achieved. In 1806, with Louis Nicolas Vauquelin), cantharidin (1810), the sigma-1 receptor agonist noscapine (1817), caffeine (1821), alizarin (later on moved...
    19 KB (2,589 words) - 22:56, 27 April 2025
  • Thumbnail for Phenylpiracetam
    PubChem. Retrieved 1 October 2024. Vavers E, Zvejniece L, Maurice T, Dambrova M (2019). "Allosteric Modulators of Sigma-1 Receptor: A Review". Front Pharmacol...
    50 KB (4,871 words) - 01:48, 19 April 2025
  • Thumbnail for Fluvoxamine
    Fluvoxamine (category Sigma agonists)
    (April 2010). "Cognition and depression: the effects of fluvoxamine, a sigma-1 receptor agonist, reconsidered". Human Psychopharmacology. 25 (3): 193–200....
    68 KB (6,053 words) - 01:56, 13 May 2025
  • Thumbnail for Selective serotonin reuptake inhibitor
    Selective serotonin reuptake inhibitor (category Sigma receptor modulators)
    gradual changes in brain signaling and receptor regulation, with some also interacting with sigma-1 receptors, particularly fluvoxamine, which may contribute...
    155 KB (16,564 words) - 11:28, 24 May 2025
  • quantum physics Sigma baryon in particle physics Sigma receptor, a neural receptor Surface charge density in classical electromagnetism Sigma, a Greek letter...
    5 KB (723 words) - 21:19, 23 April 2025
  • Cutamesine (category Sigma agonists)
    Cutamesine (SA 4503) is a synthetic sigma receptor agonist which is selective for the σ1 receptor, a chaperone protein mainly found in the endoplasmic...
    14 KB (1,438 words) - 05:41, 9 April 2025