The sigma-1 receptor (σ1R), one of two sigma receptor subtypes, is a chaperone protein at the endoplasmic reticulum (ER) that modulates calcium signaling...
34 KB (3,792 words) - 16:38, 21 May 2025
Sigma receptors (σ-receptors) are protein receptors that bind ligands such as 4-PPBP (4-phenyl-1-(4-phenylbutyl) piperidine), SA 4503 (cutamesine), ditolylguanidine...
17 KB (1,832 words) - 12:09, 22 May 2025
The sigma-2 receptor (σ2R) is a sigma receptor subtype that has attracted attention due to its involvement in diseases such as neurological diseases, neurodegenerative...
22 KB (2,332 words) - 15:38, 28 April 2025
derivative of phenylpiracetam, is a positive allosteric modulator of the sigma σ1 receptor. It is currently the only racetam known to possess this action. In...
17 KB (1,705 words) - 02:38, 22 April 2025
pregn-5-en-3β-ol-20-one 3β-sulfate – GABAA receptor negative allosteric modulator, NMDA receptor positive allosteric modulator, sigma-1 receptor agonist, TRPM3 agonist,...
19 KB (2,002 words) - 02:02, 18 May 2025
Methylphenylpiracetam (category Receptor modulators)
derivative of piracetam and a positive allosteric modulator of the sigma-1 receptor. It differs from phenylpiracetam by having a methyl group. E1R is the...
7 KB (536 words) - 18:47, 24 May 2025
Neurosteroid (section Sigma-1 receptor)
perspective on the new mechanism of antidepressants: neuritogenesis through sigma-1 receptors". Pharmacopsychiatry. 37 (Suppl 3): S208–13. doi:10.1055/s-2004-832679...
42 KB (4,402 words) - 13:14, 30 March 2025
Pridopidine (category Sigma agonists)
molecule investigational drug. Pridopidine is a selective and potent Sigma-1 Receptor agonist. It is being developed by Prilenia Therapeutics and is currently...
15 KB (1,571 words) - 03:24, 23 December 2024
Sigma (/ˈsɪɡmə/ SIG-mə; uppercase Σ, lowercase σ, lowercase in word-final position ς; Ancient Greek: σίγμα) is the eighteenth letter of the Greek alphabet...
18 KB (2,185 words) - 02:22, 27 May 2025
as an antitussive. Unlike many antitussives, it binds poorly to the sigma-1 receptor. Friedel-Crafts acylation of benzene with propionyl chloride and aluminium...
5 KB (318 words) - 05:04, 10 March 2025
emission tomography (PET) scans to image σ1 (sigma-1) receptors in the brain and other tissues. Sigma-1 receptors are proteins involved in many neurological...
6 KB (215 words) - 04:34, 23 May 2025
6-tetrahydro-5-[3-(4-methylphenyl)-5-isoxazolyl]-1-propylpyridine is a potent and selective ligand for the sigma-1 receptor, with a reported binding affinity of Ki...
2 KB (96 words) - 14:55, 17 January 2025
Memantine/donepezil (category NMDA receptor antagonists)
an NMDA receptor antagonist, among various other types of targets like 5-HT3 receptor, Nicotinic acetylcholine receptor, and Sigma-1 receptor) and donepezil...
5 KB (203 words) - 13:23, 6 May 2025
Diproqualone (category GABAA receptor positive allosteric modulators)
possibly its agonist activity at both the sigma-1 receptor and sigma-2 receptor (the function of these receptors and their clinical relevance has not yet...
4 KB (236 words) - 09:07, 21 January 2025
MS-377 (category Sigma receptor modulators)
selective antagonist of the sigma-1 receptor. It possesses anti-psychotic properties. MS-377 acts selectively at the sigma-1 receptor as an antagonist. It does...
4 KB (327 words) - 21:27, 30 March 2025
Sertraline (redirect from CP 51,974-1)
Hashimoto K (2017). "Sigma-1 Receptor Agonists and Their Clinical Implications in Neuropsychiatric Disorders". Sigma Receptors: Their Role in Disease...
104 KB (10,669 words) - 23:02, 22 May 2025
Opipramol (category Sigma agonists)
most other tricyclic antidepressants, and instead acts primarily as a sigma-1 receptor agonist. It was developed by Schindler and Blattner in 1961. Opipramol...
27 KB (2,047 words) - 20:11, 24 May 2025
Cloroqualone (category GABAA receptor positive allosteric modulators)
resulting from its agonist activity at the β subtype of the GABAa receptor and sigma-1 receptor, and was sold either alone or in combination with other ingredients...
3 KB (166 words) - 15:42, 4 March 2024
protein, the sigma-2 receptor, found in cell membranes. It is highly selective for this over the related sigma-1 receptor. The sigma-2 receptor is significant...
2 KB (216 words) - 21:23, 21 February 2025
Dimethyltryptamine (category Sigma agonists)
demonstrated the immunomodulatory potential of DMT and 5-MeO-DMT through the Sigma-1 receptor of human immune cells. This immunomodulatory activity may contribute...
174 KB (16,813 words) - 02:49, 27 May 2025
intracellular receptors that promote monoamine neurotransmission. For instance, methamphetamine acts as an agonist of sigma-1 receptor. ATS use disorders...
23 KB (2,404 words) - 22:09, 23 May 2025
alpha-1 (α1) adrenergic are G protein-coupled receptors (GPCRs) associated with the Gq heterotrimeric G protein. α1-adrenergic receptors are subdivided...
16 KB (1,527 words) - 14:51, 25 May 2025
their primary neurotransmitter, receptor or method of action. Many drugs act on more than one transmitter or receptor in the brain. Psychoactive drugs...
83 KB (8,221 words) - 08:39, 24 May 2025
Dextromethorphan (redirect from Plateau sigma)
reuptake inhibitor and a sigma-1 receptor agonist. Dextromethorphan and its major metabolite, dextrorphan, also block the NMDA receptor at high doses, which...
51 KB (4,638 words) - 04:16, 12 May 2025
achieved. In 1806, with Louis Nicolas Vauquelin), cantharidin (1810), the sigma-1 receptor agonist noscapine (1817), caffeine (1821), alizarin (later on moved...
19 KB (2,589 words) - 22:56, 27 April 2025
PubChem. Retrieved 1 October 2024. Vavers E, Zvejniece L, Maurice T, Dambrova M (2019). "Allosteric Modulators of Sigma-1 Receptor: A Review". Front Pharmacol...
50 KB (4,871 words) - 01:48, 19 April 2025
Fluvoxamine (category Sigma agonists)
(April 2010). "Cognition and depression: the effects of fluvoxamine, a sigma-1 receptor agonist, reconsidered". Human Psychopharmacology. 25 (3): 193–200....
68 KB (6,053 words) - 01:56, 13 May 2025
Selective serotonin reuptake inhibitor (category Sigma receptor modulators)
gradual changes in brain signaling and receptor regulation, with some also interacting with sigma-1 receptors, particularly fluvoxamine, which may contribute...
155 KB (16,564 words) - 11:28, 24 May 2025
quantum physics Sigma baryon in particle physics Sigma receptor, a neural receptor Surface charge density in classical electromagnetism Sigma, a Greek letter...
5 KB (723 words) - 21:19, 23 April 2025
Cutamesine (category Sigma agonists)
Cutamesine (SA 4503) is a synthetic sigma receptor agonist which is selective for the σ1 receptor, a chaperone protein mainly found in the endoplasmic...
14 KB (1,438 words) - 05:41, 9 April 2025