In the context of gene regulation: transactivation is the increased rate of gene expression triggered either by biological processes or by artificial...

The transactivation domain or trans-activating domain (TAD) is a transcription factor scaffold domain which contains binding sites for other proteins...

Intrinsic activity (IA) and efficacy (Emax) refer to the relative ability of a drug-receptor complex to produce a maximum functional response. This must...

binding sites are frequently referred to as activation functions (AFs), Transactivation domain (TAD) or Trans-activating domain TAD, not to be confused with...

expression of anti-inflammatory proteins in the nucleus (a process known as transactivation) and represses the expression of pro-inflammatory proteins in the cytosol...

Thiazolidinedione ligand dependent transactivation is responsible for the majority of anti-diabetic effects....

modification through acetylation, which directly promotes AR-mediated transactivation, apoptosis and contact-independent growth of prostate cancer cells...

promoter. Localised to the C-terminus, belongs to the nine amino acids transactivation domain family, 9aaTAD, together with Oaf1, Pip2, Pdr1, Pdr3, but also...

resulting activated form GR has two principal mechanisms of action, transactivation, and transrepression, described below. A direct mechanism of action...

receptors, the AR protein consists of several functional domains: the transactivation domain (also called the transcription-regulation domain or the amino...

gene expression via one of two pathways: Transactivation The first (direct) pathway is called transactivation whereby the activated GR dimerizes, is translocated...

contain a KIX domain or KIX-related domain that interacts with the transactivation domain of many different transcription factors. The distinction between...

protein belongs to the group of histone-modifying enzymes comprising transactivation domain 9aaTAD and is involved in the epigenetic maintenance of transcriptional...

are all involved in osteosclerosis, although Δ2ΔFosB lacks a known transactivation domain, in turn preventing it from affecting transcription through...

activity of the AP-1 and NF-κB transcription factors. In addition to transactivation, transrepression is an important pathway for the anti-inflammatory...

Tapanainen JS, Savontaus ML (June 2003). "A novel sequence variation in the transactivation regulating domain of the androgen receptor in two infertile Finnish...

mediators (transrepression) and inducing anti-inflammatory mediators (transactivation). Immunosuppressive effects are mediated by suppressing delayed hypersensitivity...

to study the function of the ERα. It has 265-fold higher potency in transactivation assays of the ERα relative to the ERβ and 70-fold preference in binding...

SJ, Calandrella SO, Barrett KE (April 2000). "Carbachol-stimulated transactivation of epidermal growth factor receptor and mitogen-activated protein kinase...

Br. potently inhibit the LPS signaling pathway by suppressing the transactivation of NF-κB". International Immunopharmacology. 28 (2): 967–976. doi:10...

contains a Rel homology domain (RHD) at its N-terminus and two C-terminal transactivation domains. c-Rel is a myeloid checkpoint protein that can be targeted...

2010). "ARF antagonizes the ability of Miz-1 to inhibit p53-mediated transactivation". Oncogene. 29 (5): 711–22. doi:10.1038/onc.2009.372. PMID 19901969...

with E2A proteins in vivo. This protein is capable of inhibiting the transactivation capability of E47, an E2A protein, in mammalian cells. This gene is...

a selective agonist of the ERα. It shows 286-fold selectivity for transactivation of the ERα over the ERβ, with EC50 values of 0.37 nM for the ERα (7-fold...

promoter of ERα-responsive genes. LKB1's catalytic activity enhances ERα transactivation compared to catalytically deficient LKB1 mutants. Direct acetylation...

glycosides from the fruits of Morinda citrifolia (noni) inhibit AP-1 transactivation and cell transformation in the mouse epidermal JB6 cell line". Cancer...

(2000). "Regulatory functions of Cdk9 and of cyclin T1 in HIV tat transactivation pathway gene expression". J. Cell. Biochem. 75 (3): 357–68. doi:10...

binds to the AR with an EC50 of 6.6 nM and is a partial agonist in transactivation modulation of the AR with an IP of 25 nM and Emax of 78% and has a...

androgen receptor (AR) and has a high potency to stimulate AR-dependent transactivation. In vivo, an equimolar dose of 1-testosterone has the same potency...

cyclin-dependent kinase 3 (cdk-3). Its phosphorylation enhances its transactivation and transcriptional activities, and enhances cell transformation. Fusion...