• Thumbnail for Tumor microenvironment
    The tumor microenvironment is a complex ecosystem surrounding a tumor, composed of cancer cells, stromal tissue (including blood vessels, immune cells...
    65 KB (7,014 words) - 05:40, 23 May 2025
  • downregulated. Tumor-associated macrophages (TAMs) have been shown to be abundantly present in the microenvironments of metastasizing tumors. Studies have...
    9 KB (979 words) - 18:53, 5 April 2025
  • and their interactions all contribute to the changing tumor microenvironment, which the tumor largely manipulates to be immunotolerant so as to avoid...
    50 KB (6,091 words) - 17:55, 21 April 2025
  • Thumbnail for Cancer immunology
    essential to maintain self-tolerance. In a tumor, however, Tregs form an immunosuppressive microenvironment. Tumor cells produce special cytokines (such as...
    33 KB (3,766 words) - 14:14, 19 June 2024
  • Thumbnail for Pancreatic cancer
    reaching the tumor. Tumor associated macrophages, neutrophils and regulatory T-cells secrete cytokines and work to create a tumor microenvironment that promotes...
    129 KB (13,579 words) - 21:55, 24 May 2025
  • Thumbnail for Halozyme
    company. It develops oncology therapies designed to target the tumor microenvironment. The company was founded in 1998 and went public in 2004. Halozyme...
    11 KB (1,002 words) - 16:11, 3 December 2024
  • site of many tumors. Studies in both humans and animal models have implicated that high numbers of Treg cells in the tumor microenvironment is indicative...
    79 KB (9,482 words) - 16:04, 19 January 2025
  • tumor cells. See the Natural killer cell page for further information on NK cells in tumor surveillance. ILC1s influence the tumor microenvironment by...
    95 KB (10,509 words) - 11:07, 17 January 2025
  • Thumbnail for Glioblastoma
    Glioblastoma (category Brain tumor)
    (July 2017). "Tumor Evolution of Glioma-Intrinsic Gene Expression Subtypes Associates with Immunological Changes in the Microenvironment". Cancer Cell...
    81 KB (9,104 words) - 22:06, 18 May 2025
  • Tumor-associated macrophages (TAMs) are a class of immune cells present in high numbers in the microenvironment of solid tumors. They are heavily involved...
    22 KB (2,510 words) - 10:16, 20 November 2024
  • Thumbnail for Tumor-infiltrating lymphocytes
    enumeration and characterization of the tumor microenvironment in diverse cancer types and across thousands of tumors, an approach largely led by Ash Alizadeh...
    24 KB (2,763 words) - 00:56, 13 May 2025
  • Thumbnail for Isaac Witz
    Sciences. He is one of the scientists who laid the foundations of the tumor microenvironment (TME) research field. Isaac Witz was born in Vienna. In September...
    15 KB (1,634 words) - 21:37, 24 January 2025
  • Thumbnail for Acinic cell carcinoma
    neoplastic transformation. Recent studies have characterized the tumor microenvironment of acinic cell carcinoma, revealing several notable features: Low...
    49 KB (5,761 words) - 03:53, 10 March 2025
  • mimicking the tumor microenvironment. Alternatively, a single-cell suspension enables scientists to collect an unbiased sampling of the whole tumor, eliminating...
    32 KB (3,639 words) - 16:33, 23 May 2025
  • Thumbnail for The Hallmarks of Cancer
    contribute to the acquisition of hallmark traits by creating the “tumor microenvironment.” Recognition of the widespread applicability of these concepts...
    37 KB (4,314 words) - 12:20, 23 May 2025
  • Thumbnail for Cancer
    Cancer (redirect from Malignant tumors)
    cancer cells by influencing the tumor microenvironment. Oncogenes build up an inflammatory pro-tumorigenic microenvironment. Hormones also play a role in...
    185 KB (20,123 words) - 17:10, 21 May 2025
  • Thumbnail for Osteosarcoma
    Controllability in Phenotypically Characterized Osteosarcoma: Role of Tumor Microenvironment". Frontiers in Immunology. 8: 918. doi:10.3389/fimmu.2017.00918...
    34 KB (3,908 words) - 13:03, 23 May 2025
  • Thumbnail for Neoplasm
    Neoplasm (redirect from Tumor)
    environmental factors and molecular changes in the local microenvironment on neoplastic evolution from tumor initiation to patient death. In the colon, a field...
    51 KB (5,895 words) - 12:49, 6 February 2025
  • Thumbnail for Rosandra N. Kaplan
    the role of the tumor microenvironment in cancer progression. She is a principal investigator and head of the tumor microenvironment and metastasis branch...
    4 KB (375 words) - 16:53, 14 May 2024
  • Thumbnail for Devil facial tumour disease
    Tasmanian Devil Facial Tumor Cells but Is Strongly Upregulated in Response to IFN-γ and Can Be Expressed in the Tumor Microenvironment". Frontiers in Immunology...
    54 KB (5,995 words) - 18:17, 23 May 2025
  • fewer side effects. Metronomic therapy is shown to affect both tumor microenvironment and tumor cells to achieve its therapeutic effects. Metronomic therapy...
    26 KB (2,948 words) - 13:28, 13 May 2025
  • 2015). "The Multifaceted Roles Neutrophils Play in the Tumor Microenvironment". Cancer Microenvironment. 8 (3): 125–58. doi:10.1007/s12307-014-0147-5. PMC 4714999...
    115 KB (13,994 words) - 08:42, 27 April 2025
  • Thumbnail for Lurbinectedin
    genes. This has two consequences. It promotes tumor cell death and normalizes the tumor microenvironment. Active transcription is the process by which...
    20 KB (1,476 words) - 19:27, 14 February 2025
  • regarded as a pioneer in the area of tumor microenvironment and widely recognized for his seminal discoveries in tumor biology, drug delivery, in vivo imaging...
    7 KB (704 words) - 23:22, 11 August 2024
  • Thumbnail for Cellular adoptive immunotherapy
    tumors, which adds difficulty to the identification of a target for all tumor cells. 2) Achieving full function of T cells and tumor microenvironment...
    19 KB (2,170 words) - 03:58, 19 September 2024
  • proteomic analysis toward a better understanding of how tumor cells manipulate their microenvironment by producing structural proteins of ECM, modifying proteins...
    11 KB (1,228 words) - 14:20, 26 May 2025
  • fibroblast; activated fibroblast) is a cell type within the tumor microenvironment that promotes tumorigenic features by initiating the remodelling...
    31 KB (3,599 words) - 22:57, 3 January 2025
  • Thumbnail for Weiping Zou
    developed an international reputation in human tumor immunosuppressive mechanisms in the tumor microenvironment. Zou serves as Director of the Center of Excellence...
    7 KB (877 words) - 11:04, 4 April 2025
  • Thumbnail for Immune checkpoint
    the immune microenvironment, leading to the activation of the A2a receptor, is negative immune feedback loop and the tumor microenvironment has relatively...
    31 KB (3,473 words) - 17:20, 19 November 2024
  • Thumbnail for Cancer stem cell
    poor methodology (i.e., the tumor cells lose their viability during transfer) or the critical importance of the microenvironment, the particular biochemical...
    88 KB (10,587 words) - 03:56, 19 May 2025