The two-pore-domain or tandem pore domain potassium channels are a family of 15 members that form what is known as leak channels which possess Goldman-Hodgkin-Katz...

Potassium channels are the most widely distributed type of ion channel found in virtually all organisms. They form potassium-selective pores that span...

common name of 'Two-pore-domain potassium channels', these channels have only one pore but two pore domains per subunit. Two-pore channels include ligand-gated...

two-pore-domain potassium channels, which confusingly have only one pore and were named for the fact that each subunit has two P (pore) domains in its primary...

"Functional characterisation of human TASK-3, an acid-sensitive two-pore domain potassium channel". Neuropharmacology. 40 (4): 551–9. doi:10.1016/S0028-3908(00)00189-1...

Long SB (January 2012). "Crystal structure of the human two-pore domain potassium channel K2P1". Science. 335 (6067): 432–6. Bibcode:2012Sci...335....

Potassium channel blockers are agents which interfere with conduction through potassium channels. Potassium channel blockers used in the treatment of...

events organized by artist Oliver Herring Two-pore-domain potassium channel, a family of potassium ion channels Task (miniseries), a 2025 American crime...

studied extensively in ion channel research. The pH activated protein possesses two transmembrane segments and a highly selective pore region, responsible for...

conductance pore. Based on sequence homology of the hydrophobic transmembrane cores, the alpha subunits of voltage-gated potassium channels are grouped...

There are commonly additional regulatory domains which serve to regulate ion conduction and channel gating. The pores may also be homotetramers or heterotetramers;...

Structurally, BK channels are homologous to voltage- and ligand-gated potassium channels, having a voltage sensor and pore as the membrane-spanning domain and a...

distinguish it from outward potassium currents. Inward rectifiers also differ from tandem pore domain potassium channels, which are largely responsible...

lipid-gated ion channel belonging to the two-pore-domain background potassium channel protein family. This type of potassium channel is formed by two homodimers...

K2P may refer to: Two-pore-domain potassium channel (K2P), a family of cell membrane leak channels Kimura's two parameter model (K2P model), a model of...

sodium channels in the membrane. The sodium influx eventually overtakes the potassium efflux (via the two-pore-domain potassium channels or leak channels, initiating...

transmembrane domains arranged around a central pore; these four domains are part of a single α-subunit in the case of most Na+ and Ca2+ channels, whereas...

and into the cytoplasm. Each channel consists of domains which span the plasma membrane, forming the K+-selective pore region through which the K+ ions...

oxide and cyclopropane, xenon activates the two-pore domain potassium channel TREK-1. A related channel TASK-3 also implicated in the actions of inhalation...

tetrameric channels. It is distantly related to the BTB/POZ domain Pfam PF00651. Potassium channels are the most diverse group of the ion channel family....

Calcium-activated potassium channels are potassium channels gated by calcium, or that are structurally or phylogenetically related to calcium gated channels. They...

subunits have two transmembrane spans and form the channel's pore. The SUR subunits have three additional transmembrane domains, and contain two nucleotide-binding...

transmembrane helices from the 4 domains line up to form the channel proper; S5 and S6 helices are thought to line the inner pore surface, while S1–4 helices...

sodium channels, the region linking domains III and IV is also important for channel function. This DIII-IV linker is responsible for wedging the pore gate...

sodium channels, the region linking domains III and IV is also important for channel function. This DIII-IV linker is responsible for wedging the pore gate...

heterologously expressed hERG potassium channel comprises four identical alpha subunits, which form the channel's pore through the plasma membrane. Each...

occupied to open the ion channel. The pore is mainly formed by the half helix 2 in a way which resembles an inverted potassium channel. The...

family of potassium channels. KvLQT1 is made of six membrane-spanning domains S1-S6, two intracellular domains, and a pore loop. The KvLQT1 channel is made...

3 The structure of the pore is similar to other ion channels that contain P-loops. The P-loop enters the membrane of the pore from the extracellular side...

calmodulin binding domain (CaMBD) is a protein domain found in small-conductance calcium-activated potassium channels (SK channels). These channels are independent...