The two-pore-domain or tandem pore domain potassium channels are a family of 15 members that form what is known as leak channels which possess Goldman-Hodgkin-Katz...

Potassium channels are the most widely distributed type of ion channel found in virtually all organisms. They form potassium-selective pores that span...

common name of 'Two-pore-domain potassium channels', these channels have only one pore but two pore domains per subunit. Two-pore channels include ligand-gated...

two-pore-domain potassium channels, which confusingly have only one pore and were named for the fact that each subunit has two P (pore) domains in its primary...

Potassium channel blockers are agents which interfere with conduction through potassium channels. Potassium channel blockers used in the treatment of...

"Functional characterisation of human TASK-3, an acid-sensitive two-pore domain potassium channel". Neuropharmacology. 40 (4): 551–9. doi:10.1016/S0028-3908(00)00189-1...

Long SB (January 2012). "Crystal structure of the human two-pore domain potassium channel K2P1". Science. 335 (6067): 432–6. Bibcode:2012Sci...335....

conductance pore. Based on sequence homology of the hydrophobic transmembrane cores, the alpha subunits of voltage-gated potassium channels are grouped...

Structurally, BK channels are homologous to voltage- and ligand-gated potassium channels, having a voltage sensor and pore as the membrane-spanning domain and a...

events organized by artist Oliver Herring Two-pore-domain potassium channel, a family of potassium ion channels The Task (disambiguation) Task force (disambiguation)...

There are commonly additional regulatory domains which serve to regulate ion conduction and channel gating. The pores may also be homotetramers or heterotetramers;...

distinguish it from outward potassium currents. Inward rectifiers also differ from tandem pore domain potassium channels, which are largely responsible...

studied extensively in ion channel research. The pH activated protein possesses two transmembrane segments and a highly selective pore region, responsible for...

transmembrane domains arranged around a central pore; these four domains are part of a single α-subunit in the case of most Na+ and Ca2+ channels, whereas...

sodium channels in the membrane. The sodium influx eventually overtakes the potassium efflux (via the two-pore-domain potassium channels or leak channels, initiating...

Calcium-activated potassium channels are potassium channels gated by calcium, or that are structurally or phylogenetically related to calcium gated channels. They...

depending on channel state. The two transmembrane domains (TMD1 and TMD2) of each of the three ASIC subunits are responsible for the channel's pore. TMD2 is...

occupied to open the ion channel. The pore is mainly formed by the half helix 2 in a way which resembles an inverted potassium channel. The...

3 The structure of the pore is similar to other ion channels that contain P-loops. The P-loop enters the membrane of the pore from the extracellular side...

oxide and cyclopropane, xenon activates the two-pore domain potassium channel TREK-1. A related channel TASK-3 also implicated in the actions of inhalation...

SK channels (small conductance calcium-activated potassium channels) are a subfamily of calcium-activated potassium channels. They are so called because...

or pH. The CLC family of chloride channels contains 10 or 12 transmembrane helices. Each protein forms a single pore. It has been shown that some members...

and into the cytoplasm. Each channel consists of domains which span the plasma membrane, forming the K+-selective pore region through which the K+ ions...

family of potassium channels. KvLQT1 is made of six membrane-spanning domains S1-S6, two intracellular domains, and a pore loop. The KvLQT1 channel is made...

lipid-gated ion channel belonging to the two-pore-domain background potassium channel protein family. This type of potassium channel is formed by two homodimers...

sodium channels, the region linking domains III and IV is also important for channel function. This DIII-IV linker is responsible for wedging the pore gate...

subunits have two transmembrane spans and form the channel's pore. The SUR subunits have three additional transmembrane domains, and contain two nucleotide-binding...

K2P may refer to: Two-pore-domain potassium channel (K2P), a family of cell membrane leak channels Kimura's two parameter model (K2P model), a model of...

channels. (CRC Press, 2015).[page needed] Christensen, A. H; Chatelain, F. C.; Huttner, I. G.; et al. (2016). "The two-pore domain potassium channel,...

sodium channels, the region linking domains III and IV is also important for channel function. This DIII-IV linker is responsible for wedging the pore gate...