The enzyme Uridine monophosphate synthase (EC 4.1.1.23, UMPS) (orotate phosphoribosyl transferase and orotidine-5'-decarboxylase) catalyses the formation...

synthase. Defective UMP synthase can result in orotic aciduria, a metabolic disorder. In a study, gerbils fed a combination of uridine monophosphate,...

sequencing of the UMPS gene. Treatment is administration of uridine monophosphate (UMP) or uridine triacetate (which is converted to UMP). These medications...

synthase converts OMP into uridine 5′-monophosphate. If UMP synthase is defective, orotic aciduria can result. PubChem. "Orotidine-5'-monophosphate"...

performed in aerobes by the ATP synthase during oxidative phosphorylation) AMP can be converted into inosine monophosphate by the enzyme myoadenylate deaminase...

Retrieved 20 October 2014. Bailey, CJ (2009). "Orotic aciduria and uridine monophosphate synthase: a reappraisal". Journal of Inherited Metabolic Disease. 32:...

decarboxylated by orotidine-5'-phosphate decarboxylase to form uridine monophosphate (UMP). PRPP transferase catalyzes both the ribosylation and decarboxylation...

biosynthesis. It catalyzes the decarboxylation of orotidine monophosphate (OMP) to form uridine monophosphate (UMP). The function of this enzyme is essential to...

utilized in both cell regulation and cell signaling as seen in adenosine-monophosphate (AMP). Furthermore, ribonucleotides can be converted to adenosine triphosphate...

in UMP synthase is associated with hypochromic anemia. In mammals, this bifunctional enzyme UMPS converts orotic acid into uridine monophosphate (UMP)...

5'-monophosphate, is a molecule formed in vivo from 5-fluorouracil and 5-fluorodeoxyuridine. FdUMP acts as a suicide inhibitor of thymidylate synthase (TS)...

donor for thymidylate synthase, for methylation of 2-deoxy-uridine-5-monophosphate (dUMP) to 2-deoxy-thymidine-5-monophosphate (dTMP). The coenzyme is...

ribose sugar to form the ribonucleoside uridine. When a phosphate attaches to uridine, uridine 5′-monophosphate is produced. Uracil undergoes amide-imidic...

are thymine, cytosine and uracil (which is only found in RNA). Uridine monophosphate biosynthesis involves an enzyme that is located in the mitochondrial...

for DNA replication. Thymidylate synthase methylates deoxyuridine monophosphate (dUMP) to form thymidine monophosphate (dTMP). Administration of 5-FU causes...

AICAR + fTHF → FAICAR + THF The last step is catalyzed by Inosine monophosphate synthase. FAICAR → IMP + H2O In eukaryotes the second, third, and fifth step...

Actinomycin D Adenine Adenosine Adenosine diphosphate (ADP) Adenosine monophosphate (AMP) Adenosine triphosphate (ATP) Adenylate cyclase Adiponectin Adonitol...

5-FU which in turn is a thymidylate synthase inhibitor, hence inhibiting the synthesis of thymidine monophosphate (ThMP), the active form of thymidine...

10: Thiazole synthase EC 2.8.1.11: Molybdopterin synthase sulfurtransferase EC 2.8.1.12: Molybdopterin synthase EC 2.8.1.13: tRNA-uridine 2-sulfurtransferase...

can be interconverted to adenosine triphosphate (ATP) and adenosine monophosphate (AMP). ATP contains one more phosphate group than ADP, while AMP contains...

UDP-galactosamine accumulation within cells, and uridine triphosphate (UTP), UDP, and uridine monophosphate (UMP) decrease. The depletion of high-energy molecules...

dihydroorotate dehydrogenase". "Entrez Gene: UMPS uridine monophosphate synthetase". "Entrez Gene: UCK2 uridine-cytidine kinase 2". Chitrakar I, Kim-Holzapfel...

derivative. Cytarabine-5´-monophosphate is deaminated by deoxycytidylate deaminase, leading to the inactive uridine-5´-monophosphate analog. Cytarabine-5´-triphosphate...

proteins, including working with the enzymes dihydroorotate synthase and uridine monophosphate synthase. When Jones moved to University of North Carolina at...

or orotate. This combination synthesizes uridine monophosphate, which can then be converted into uridine triphosphate (UTP). UMP also functions as a...

Guanosine triphosphate to Cytidine triphosphate and Uridine triphosphate, low Adenosine monophosphate levels, high glutaminolytic capacities, release of...

thiamine + ATP → TPP + AMP (EC 2.7.6.2). However, recent findings reveal that uridine 5′-triphosphate (UTP), rather than ATP, is the preferred substrate for...

monosaccharides by glycosyltransferase from a reactive sugar-phosphate donor such as uridine diphosphate glucose (UDP-Glc) to an acceptor hydroxyl group on the growing...

thymidine, by the enzyme thymidylate synthase. The second route is sufficient to supply thymidine monophosphate for DNA repair. When a cell prepares to...

oxidation of dihydroorotate to orotate, which is part of the de novo uridine 5'-monophosphate (UMP) synthesis pathway. This oxidation is mediated by flavin mononucleotide...