V(D)J recombination (variable–diversity–joining rearrangement) is the mechanism of somatic recombination that occurs only in developing lymphocytes during...

required for opening the hairpins that are formed on DNA ends during V(D)J recombination, a specific type of NHEJ, and may also participate in end trimming...

vaccine development. V(D)J recombination in organisms with an adaptive immune system is a type of site-specific genetic recombination that helps immune cells...

combination is called V(D)J recombination and discussed below. Somatic recombination of immunoglobulins, also known as V(D)J recombination, involves the generation...

Eukaryotic supergroups. V(D)J recombination, although not a DNA TE, is remarkably similar to transposons. V(D)J recombination is the process by which...

number of genes available to V(D)J recombination, gene conversion between pseudogenic V segments and the currently-active V segment occur with SMH, thereby...

cells. TdT adds N-nucleotides to the V, D, and J exons of the TCR and BCR genes during antibody gene recombination, enabling the phenomenon of junctional...

Impact on the junctional repair steps of V(D)J recombination". Molecular Immunology. 120: 93–100. doi:10.1016/j.molimm.2020.01.018. PMC 7184946. PMID 32113132...

VDJ genes) to create millions of permutations, in a process called V(D)J recombination. RAG-1 and RAG-2 are proteins at the ends of VDJ genes that separate...

repair 1C) gene. Artemis is a nuclear protein that is involved in V(D)J recombination and DNA repair. The protein has endonuclease activity on 5' and 3'...

with the RAG1 protein, RAG2 forms a V(D)J recombinase, a protein complex required for the process of V(D)J recombination during which the variable regions...

process of V(D)J recombination, but possessing distinct constant domains in their heavy chains. Naïve mature B cells produce both IgM and IgD, which are...

Nobel Prize for Physiology or Medicine in 1987 for his discovery of V(D)J recombination, the genetic mechanism which produces antibody diversity. Although...

Recombination signal sequences are conserved sequences of noncoding DNA that are recognized by the RAG1/RAG2 enzyme complex during V(D)J recombination...

joining of gene segments during the process of V(D)J recombination. This process of V(D)J recombination has vital roles for the vertebrate immune system...

created. Second, V(D)J recombination randomly selects one variable (V), one diversity (D), and one joining (J) region for genetic recombination and discards...

the chromosome. NHEJ is also used to repair DSBs generated during V(D)J recombination when gene regions are rearranged to create the unique antigen binding...

cells through random somatic rearrangement. This process, known as V(D)J recombination, is important because it increases the receptor diversity which increases...

mutations. Somatic recombination occurs physiologically in the assembly of the B cell receptor and T-cell receptor genes (V(D)J recombination), as well as in...

is encoded by the V, (D), and J gene segments, the recombination of which gives rise to Ig gene allelic exclusion. V(D)J recombination occurs imprecisely...

immunoglobulin genes of Reed–Sternberg cells have undergone both V(D)J recombination and somatic hypermutation, establishing an origin from a germinal...

Artemis complex is a protein complex that functions in V(D)J recombination, the somatic recombination process which generates diversity in T cell receptors...

as intermediaries in meiosis and V(D)J recombination, which are primarily repaired through homologous recombination and non-homologous end joining. Both...

dancer. V(D)J recombination, a mechanism of genetic recombination Visual J Sharp, or Visual J#, a programming language Victory over Japan Day, V-J Day Vojska...

protein kinase (DNA-PKcs aka PRKDC), which leads to faulty V(D)J recombination. V(D)J recombination is necessary for recognition of a diverse range of antigens...

(spleen and thymus) and uses V(D)J recombination to create antigen recognition sites, rather than using genetic recombination in the variable lymphocyte...

single hybridoma cell, which by chance includes the appropriate V(D)J recombination to produce the desired antibody, is cloned to produce a large population...

cell receptors. These distinct receptors are formed by process of V(D)J recombination gene rearrangement stimulated by RAG1 and RAG2 genes. This process...

repair, which rejoins double-strand breaks. It is also required for V(D)J recombination, a process that utilizes NHEJ to promote immune system diversity...

in the periphery, they rearrange special segments of their DNA [V(D)J recombination process]. This process requires them to make DSBs, which are difficult...