The alternative pathway is a type of cascade reaction of the complement system and is a component of the innate immune system, a natural defense against...

classical complement pathway is one of three pathways which activate the complement system, which is part of the immune system. The classical complement pathway...

biochemical pathways activate the complement system: the classical complement pathway, the alternative complement pathway, and the lectin pathway. The alternative...

formation can occur in three different pathways: the classical, lectin, and alternative pathways. Cleavage of complement C3 by a free floating convertase,...

lectin pathway or MBL pathway is a type of cascade reaction in the complement system, similar in structure to the classical complement pathway, in that...

the bloodstream. The encoded protein is a component of the alternative complement pathway best known for its role in humoral suppression of infectious...

alternative pathway of complement activation. Factor B circulates in the blood as a single chain polypeptide. Upon activation of the alternative pathway, it is...

activation of the complement system. Its activation is required for both classical and alternative complement activation pathways. People with C3 deficiency...

response. Different complement receptors can participate in either the classical complement pathway, the alternative complement pathway, or both. White blood...

(mRNA) of the complement factor B (CFB) gene, preventing CFB protein production. CFB is a key component of the alternative pathway of complement activation...

was an American immunologist, an early investigator of the alternative complement pathway (a system of defense not dependent upon antibodies). Pillemer...

Alternative-complement-pathway C3/C5 convertase (EC 3.4.21.47, complement component C3/C5 convertase (alternative), proenzyme factor B, properdin factor...

complement pathway in particular the alternative complement pathway is evolutionary ancient. The TEP1 cascade most closely resembles the alternative pathway...

"Simplified assays of hemolytic activity of the classical and alternative complement pathways". Journal of Immunological Methods. 72 (1): 49–59. doi:10...

disease spirochetes to the bacteriolytic activities of the alternative complement pathway of various host species may determine its reservoir host association...

species is the main inhibitor of the alternative complement pathway. fHbp protects meningococci from complement-mediated death in human serum experiments...

energy (anabolic pathway), or break down complex molecules and release energy in the process (catabolic pathway). The two pathways complement each other in...

immunoglobulins inhibit factor H (a complement regulatory protein) causing uninhibited activation of the alternative complement pathway and C3 deposition in the...

(complement component 1, C1) is a protein complex involved in the complement system. It is the first component of the classical complement pathway and...

type III hypersensitivity reaction). The activation of the alternative complement pathway results in the deposition of IgA aggregates or IgA complexes...

even be required. Complement proteins involved in innate opsonization include C4b, C3b and iC3b. In the alternative pathway of complement activation, circulating...

the C3bBb C3 convertase of the alternative pathway. Thus, by limiting the amplification convertases of the complement cascade, DAF indirectly blocks the...

the alternative complement pathway and regulates the cleavage of C3, generation of downstream effectors, and the amplification of the terminal pathway. In...

classical complement pathway of the complement system. The antibodies IgM and all IgG subclasses except IgG4 are able to initiate the complement system....

M protein also inhibits opsonization by the alternative complement pathway by binding to host complement regulators. The M protein found on some serotypes...

cleavage can occur via three mechanisms (classical pathway, alternative pathway and lectin pathway) that ultimately lead to the formation of a C3 convertase...

H is to regulate the alternative pathway of the complement system, a key component of innate immunity. It ensures that complement activation is directed...

the alternative complement pathway and also interferes with complement regulation by binding to complement factor H, an inhibitor of the complement cascade...

entire complement pathway. Consequently, levels of all complement proteins become low. The complement pathway is composed of several subset pathways: the...

physiological complement enzymes, associate to the cell-surface and mediate the classical pathway (C4b2b3b, or C4b2a3b depending on source) or the alternative pathway...