Cyclin-dependent kinase 2, also known as cell division protein kinase 2, or Cdk2, is an enzyme that in humans is encoded by the CDK2 gene. The protein...
35 KB (4,161 words) - 15:56, 12 April 2025
protein kinase, cyclin-dependent kinase (CDK), with a regulatory subunit, cyclin. Once cyclin-dependent kinases bind to cyclin, the formed complex is in...
18 KB (2,262 words) - 22:16, 16 December 2023
Cyclin-dependent kinase 4 (CDK4), also known as cell division protein kinase 4, is an enzyme that is encoded by the CDK4 gene in humans. CDK4 is a member...
30 KB (3,563 words) - 20:30, 29 May 2025
kinase 6 (CDK6) is an enzyme encoded by the CDK6 gene. It is regulated by cyclins, more specifically by Cyclin D proteins and Cyclin-dependent kinase...
35 KB (4,042 words) - 05:00, 1 April 2024
Cyclin-dependent kinases (CDKs) are a predominant group of serine/threonine protein kinases involved in the regulation of the cell cycle and its progression...
35 KB (3,823 words) - 10:07, 12 May 2025
A cyclin-dependent kinase inhibitor protein (also known as CKIs, CDIs, or CDKIs) is a protein that inhibits the enzyme cyclin-dependent kinase (CDK) and...
10 KB (1,169 words) - 14:06, 24 May 2025
Cyclin-dependent kinase 5 is a protein, and more specifically an enzyme, that is encoded by the Cdk5 gene. It was discovered 15 years ago, and it is saliently...
41 KB (5,162 words) - 05:30, 24 March 2025
Cyclin-dependent kinase 9 or CDK9 is a cyclin-dependent kinase associated with P-TEFb. The protein encoded by this gene is a member of the cyclin-dependent...
12 KB (1,460 words) - 23:03, 27 March 2024
Cyclin-dependent kinase 1 also known as CDK1 or cell division cycle protein 2 homolog is a highly conserved protein that functions as a serine/threonine...
25 KB (2,896 words) - 12:38, 29 August 2024
targets the mitotic cyclins for degradation, resulting in the inactivation of M-CDK (mitotic cyclin-dependent kinase) complexes, promoting exit from...
31 KB (4,185 words) - 08:02, 24 May 2025
CDKN2A (redirect from Cyclin-dependent kinase inhibitor 2A)
CDKN2A, also known as cyclin-dependent kinase inhibitor 2A, is a gene which in humans is located at chromosome 9, band p21.3. It is ubiquitously expressed...
26 KB (3,368 words) - 05:19, 2 February 2025
CDKN1C imprinted gene. Cyclin-dependent kinase inhibitor 1C is a tight-binding inhibitor of several G1 cyclin/Cdk complexes and a negative regulator of...
17 KB (2,000 words) - 14:41, 9 February 2024
proteins that form holoenzymes with cyclin-dependent protein kinases (Cdk), which they activate. The abundance of cyclins is generally regulated by protein...
39 KB (4,605 words) - 19:08, 12 April 2025
Cyclin-dependent kinase 7, or cell division protein kinase 7, is an enzyme that in humans is encoded by the CDK7 gene. The protein encoded by this gene...
20 KB (2,347 words) - 18:36, 9 January 2025
Cyclins are proteins that control the progression of a cell through the cell cycle by activating cyclin-dependent kinases (CDK). Cyclins were originally...
19 KB (1,762 words) - 20:50, 16 February 2025
(CDK/MAPK/GSK3/CLK) kinase group. The closest relatives of MAPKs are the cyclin-dependent kinases (CDKs). The first mitogen-activated protein kinase to be discovered...
46 KB (5,510 words) - 21:54, 29 November 2024
P21 (section p53 dependent response)
(alternatively p21Waf1), also known as cyclin-dependent kinase inhibitor 1 or CDK-interacting protein 1, is a cyclin-dependent kinase inhibitor (CKI) that is capable...
34 KB (3,931 words) - 20:49, 22 May 2025
/calmodulin-dependent protein kinase II (CaM kinase II or CaMKII) is a serine/threonine-specific protein kinase that is regulated by the Ca2+ /calmodulin complex...
29 KB (3,458 words) - 13:38, 23 May 2025
more complex cell type evolved to respond to a wider array of signals. Cyclin dependent kinases (CDKs) are a group of several different kinases involved...
34 KB (3,808 words) - 15:55, 11 April 2025
cell cycle. Cyclins function as regulators of CDKs (cyclin-dependent kinase). Different cyclins exhibit distinct expression and degradation patterns...
49 KB (5,475 words) - 19:54, 22 May 2025
protein kinases". EMBO J. 11 (8): 2909–17. doi:10.1002/j.1460-2075.1992.tb05360.x. PMC 556772. PMID 1639063. "Entrez Gene: CDK3 cyclin-dependent kinase 3"...
7 KB (771 words) - 19:05, 28 December 2023
In cell biology, protein kinase A (PKA) is a family of serine-threonine kinases whose activity is dependent on cellular levels of cyclic AMP (cAMP). PKA...
27 KB (2,665 words) - 16:53, 12 May 2025
Naudts M, et al. (April 2004). "B1-type cyclin-dependent kinases are essential for the formation of stomatal complexes in Arabidopsis thaliana". The Plant...
78 KB (9,148 words) - 19:21, 26 May 2025
The IκB kinase (IkappaB kinase or IKK) is an enzyme complex that is involved in propagating the cellular response to inflammation, specifically the regulation...
14 KB (1,447 words) - 09:31, 22 December 2023
division cycle. Cyclins function as activating subunits of enzymatic complex together with cyclin-dependent kinases (CDKs). Different cyclins exhibit distinct...
11 KB (1,435 words) - 20:58, 22 December 2023
The Cyclin D/Cdk4 complex is a multi-protein structure consisting of the proteins Cyclin D and cyclin-dependent kinase 4, or Cdk4, a serine-threonine kinase...
25 KB (2,805 words) - 03:43, 6 May 2024
cyclin-B1 is a protein that in humans is encoded by the CCNB1 gene. Cyclin B1 is a regulatory protein involved in mitosis. The gene product complexes...
25 KB (3,276 words) - 07:43, 10 June 2024
biology, extracellular signal-regulated kinases (ERKs) or classical MAP kinases are widely expressed protein kinase intracellular signalling molecules that...
11 KB (1,183 words) - 16:06, 4 May 2025
kinase 8 is an enzyme that in humans is encoded by the CDK8 gene. The protein encoded by this gene is a member of the cyclin-dependent protein kinase...
21 KB (2,557 words) - 01:16, 24 April 2022
kinases, phosphoinositide-dependent kinase-1 (PDPK1 at threonine 308 in Akt1 and threonine 309 in Akt2) and the mammalian target of rapamycin complex...
35 KB (3,831 words) - 20:54, 25 May 2025