Apurinic/apyrimidinic (AP) endonuclease is an enzyme that is involved in the DNA base excision repair pathway (BER). Its main role in the repair of damaged...

contain two AP endonucleases: endonuclease IV (endoIV) and exonuclease III (exoIII) while in eukaryotes, there is only one AP endonuclease. Repair of DNA...

phage-T4 UV endonuclease; Micrococcus luteus UV endonuclease; AP site-DNA 5'-phosphomonoester-lyase; and X-ray endonuclease III. Since DNA AP lyase is a...

Antiparallel Antisense Antisense RNA Antisense strand Antisense therapy AP endonuclease AP site Apert syndrome Apoptosis Applied genetics Arg Arrayed library...

methylated bases, or uracil in DNA. The AP site can then be cleaved by an AP endonuclease, leaving 3'-hydroxyl and deoxyribose-5-phosphate termini (see DNA structure)...

specific damaged or inappropriate bases, forming AP sites. These are then cleaved by an AP endonuclease. The resulting single-strand break can then be processed...

DNA-glycosylase, endonuclease V, deoxyribonucleate pyrimidine dimer glycosidase, pyrimidine dimer DNA glycosylase, T4-induced UV endonuclease, PD-DNA glycosylase)...

DNA synthesis. Direct physical interaction between this protein and AP endonuclease 1 during long-patch base excision repair provides coordinated loading...

the endonuclease IV consists of several activities such as AP endonuclease, 3'-diesterase, 3'->5' exonuclease, and 3'phosphatase. The endonuclease IV is...

as an intermediary step in base excision repair. These AP sites are removed by AP endonucleases, which effect single strand breaks around the site. Nucleotide...

to identify and repair such sites. Class II AP endonucleases cleave the phosphodiester backbone 5' to the AP site, thereby initiating a process known as...

to detect SNPs. SNP-RFLP makes use of the many different restriction endonucleases and their high affinity to unique and specific restriction sites. By...

CRISPR system from Streptococcus pyogenes uses the protein Cas9, an endonuclease functioning with two small RNAs—crRNA and tracrRNA—to form a four-component...

(CRISPR-associated protein 12a, previously known as Cpf1) is an RNA-guided endonuclease-exonuclease that forms an essential component of the CRISPR systems found...

Endonuclease III-like protein 1 is an enzyme that in humans is encoded by the NTHL1 gene. As reviewed by Li et al., NTHL1 is a bifunctional DNA glycosylase...

Doudna JA, Charpentier E (2012). "A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity". Science. 337 (6096): 816–821. Bibcode:2012Sci...

short distance on either side of the site of damage. It then acts as an endonuclease to incise the damaged DNA strand on the 5' side of the damaged site....

(DBD), double-strand breaks (DSBs) in target DNA by the restriction endonucleases (FokI and Cas), and the repair of DSBs through homology-directed recombination...

DNA RNase activity 3' phosphatase activity AP endonuclease activity (later found to be called endonuclease II). Exonuclease IV adds a water molecule,...

endonucleases and many phosphatases involved in intracellular signaling. AP endonuclease proteins EC 4.2.99.18, DNase I proteins EC 3.1.21.1, Synaptojanin,...

Apurinic/apyrimidinic (AP) sites are a common form of DNA damage that inhibit DNA replication and transcription. AP endonuclease 1 (APEX1), an enzyme produced...

glycosylase activity (EC) and AP lyase activity (EC). Examples include formamidopyrimidine-DNA glycosylases (Fpg; MutM) and endonuclease VIII (Nei). Formamidopyrimidine-DNA...

at low salt concentration. Nuclease MB is a specific DNA and RNA exo-endonuclease which will degrade single-stranded extensions from the ends of DNA and...

activity EC 3.2.2.- and AP lyase activity EC 4.2.99.18. Examples include formamidopyrimidine-DNA glycosylases (Fpg; MutM) and endonuclease VIII (Nei). Formamidopyrimidine-DNA...

oligonucleotides, mismatch binding enzymes of the mutS family or specific endonucleases from bacteria or phages. Nevertheless, all these strategies increase...

ChIP-sequencing, was utilized to map both; damage in AP sites, and the enzyme responsible for its repair, AP endonuclease 1 (APE1). Both of these genome-wide mapping...

glycosylase, generating an abasic (AP) site. The resulting abasic site is then recognised by enzymes (AP endonucleases) that break a phosphodiester bond...

Cyclin T1, a human gene GalNAc-T1, a human gene Ribonuclease T1, a fungal endonuclease TNM staging system, classification for a small cancer tumor T1, longitudinal...

methylated cytosine. After an AP site is formed, AP endonuclease creates a nick in the phosphodiester backbone of the AP site that was formed when the...

cell death. Apoptosis is characterized by the activation of endogenous endonucleases, particularly the caspase-3 activated DNase (CAD), with subsequent cleavage...