The fragment antigen-binding region (Fab region) is a region on an antibody that binds to antigens. It is composed of one constant and one variable domain...

complementary binding sites, called epitopes in antigens and paratopes in antibody. In an antibody, the Fab (fragment, antigen-binding) region is formed from...

therapeutics, the Fc region of immunoglobulins has been engineered to contain an antigen-binding site. This type of antigen-binding fragment is called Fcab...

cytometry, immunohistochemistry, and as antigen-binding domains of artificial T cell receptors (chimeric antigen receptor). Unlike monoclonal antibodies...

are composed of two fragments: antigen binding region (Fab region) and the fragment crystallizable region (Fc region). The Fab region is able to bind to...

partitioned into two antigen-binding fragments (Fab), containing one VL, VH, CL, and CH1 domain each, as well as the crystallisable fragment (Fc), forming the...

the latter portion of the endogenous pathway (e.g. proteolysis of antigens for binding to MHC I molecules). While the joint distinction between the two...

Fab (monomeric binding) or F(ab')2 (dimeric binding). The fragment antigen-binding region, or Fab, is the selective antigen-binding region. An antibody...

contact with the antigen and are involved in binding antigen, while the framework regions support the binding of the CDR to the antigen and aid in maintaining...

specific for a certain antigen or surface component, bind to the pathogen with their Fab region (fragment antigen binding region), their Fc regions point...

resisting. Hinge region portion of antibody structure between the fragment antigen-binding region and the fragment crystallizable region Living hinge a...

antibodies to that specific antigen. Self-antigens are suppressed by regulatory T cells. Predicting which (fragments of) antigens will be presented to the...

antigen-binding site, is the part of an antibody which recognizes and binds to an antigen. It is a small region at the tip of the antibody's antigen-binding...

between antigen-dependent and antigen-independent categories. These theories consider a specific combination of antigen peptide sequence and the binding groove...

the new ability to target a specific antigen. The receptors are chimeric in that they combine both antigen-binding and T cell activating functions into...

combinatorial approach that engineers the Fc constant region of an immunoglobulin into a novel antigen-binding site. "F-star starts its operations" (PDF). F-Star...

Fab: fragment, antigen-binding (one arm) F(ab')2: fragment, antigen-binding, including hinge region (both arms) Fab': fragment, antigen-binding, including...

antibodies fragments engineered from the constant region of an antibody (Fc). In naturally occurring antibodies (such as IgGs), the antigen-binding sites are...

antibody fragment consisting of a single monomeric variable antibody domain. Like a whole antibody, it is able to bind selectively to a specific antigen. With...

subunits to Fc fragments (made of CH2 region) of IgG or IgM, which has formed a complex with antigens. C4b and C3b are also able to bind to antigen-associated...

recognizing fragments of antigen as peptides bound to major histocompatibility complex (MHC) molecules. The binding between TCR and antigen peptides is...

"Protein A" after the antigen fraction isolated by Jensen. It has been shown via crystallographic refinement that the primary binding site for protein A...

the antigen binding region consists of the variable domains of the heavy and light chains (VH and VL). Heavy-chain antibodies can bind antigens despite...

variable fragments (scFv) and Fab fragments also bind to protein L. Despite this wide binding range, protein L is not a universal antibody-binding protein...

comprise one binding region, one hinge region as a connector, and one effector domain. The binding region is a modified single-chain variable fragment (scFv)...

self antigens, yet T lymphocytes can react against the donor MHC's peptide-binding groove, the variable region of MHC holding the presented antigen's epitope...

latter in communicating with antigen-presenting cells. The TCR complex and CD4 bind to distinct regions of the antigen-presenting MHC class II molecule...

an immunoglobulin and the maltose-binding protein of Escherichia coli: production, purification and antigen binding". Protein Engineering. 7 (2): 271–80...

by binding and neutralizing the pro-inflammatory cytokine, TNF-α. Multiple autoimmune disorders are caused by the binding of IgG to self antigens. Since...

Lectins are carbohydrate-binding proteins that are highly specific for sugar groups that are part of other molecules, so cause agglutination of particular...