2DPL. GMP synthase is the second step in the generation of GMP from IMP; the first step occurs when IMP dehydrogenase generates XMP, and then GMP synthetase...

biological role of cyclic di-GMP was first uncovered when it was identified as an allosteric activator of a cellulose synthase found in Gluconacetobacter...

Cyclic GMP-AMP synthase (cGAS, cGAMP synthase), belonging to the nucleotidyltransferase family, is a cytosolic DNA sensor that activates a type-I interferon...

from IMP via the action of IMP dehydrogenase, and it forms GMP via the action of GMP synthase. Also, XMP can be released from XTP by enzyme deoxyribonucleoside...

(IMPDH) converts IMP into XMP GMP synthase converts XMP into GMP GMP reductase converts GMP back into IMP adenylosuccinate synthase converts IMP to adenylosuccinate...

Cyclic GMP-AMP synthase is a protein that in humans is encoded by the CGAS gene. It's an enzyme, a nucleotidyltransferase, a cyclic GMP-AMP synthase. GRCh38:...

anthranilate synthase and 4-amino-4-deoxychorismate (ADC) synthase; CTP synthase; GMP synthase; glutamine-dependent carbamoyl-phosphate synthase;...

ribazoletransferase (EC 2.7.8.26, CobS, cobalamin synthase, cobalamin-5'-phosphate synthase, cobalamin (5'-phosphate) synthase) is an enzyme with systematic name...

cyclic di-GMP is bound to the enzyme. In plants, cellulose is synthesized by large cellulose synthase complexes (CSCs), which consist of synthase protein...

4-cyclohexadiene-1-carboxylate synthase, iron-regulated ABC transporter, glycine dehydrogenase subunit 2, GMP synthase and a hypothetical protein. A.C...

Nitric oxide synthases (NOSs) are a family of enzymes catalyzing the production of nitric oxide (NO) from L-arginine. NO is an important cellular signaling...

2-amino-2′-deoxyadenylo-succinate synthase * * No Wikipedia article EC 6.3.5.1: NAD+ synthase (glutamine-hydrolysing) EC 6.3.5.2: GMP synthase (glutamine-hydrolysing)...

The cGAS–STING pathway (cyclic GMP-AMP synthase - stimulator of interferon genes) is a component of the innate immune system that functions to detect the...

unnamed Coxiella-related species in the proteins glutamine-hydrolyzing GMP synthase, type I methionyl aminopeptidase, ribonucleoside-diphosphate reductase...

administration of a nitric oxide synthase inhibitor, Nω-nitro-L-arginine, and drug-induced increase in cerebellar cyclic GMP in vivo". Neurochemical Research...

belong to a large family of cyclic nucleotide PDEs that catalyze cAMP and cGMP hydrolysis. The interest in PDEs as molecular targets of drug action has...

(cyclic GMP-AMP, cGAMP) is the first cyclic di-nucleotide found in metazoa. In mammalian cells, cGAMP is synthesized by cyclic GMP-AMP synthase (cGAS)...

Endothelial NOS (eNOS), also known as nitric oxide synthase 3 (NOS3) or constitutive NOS (cNOS), is an enzyme that in humans is encoded by the NOS3 gene...

Glycogen synthase kinase 3 (GSK-3) is a serine/threonine protein kinase that mediates the addition of phosphate molecules onto serine and threonine amino...

of GMP requires an intermediate step: IMP is first oxidized by NAD⁺ to form xanthosine monophosphate (XMP), which is subsequently converted into GMP via...

into cyclic GMP. While studying cyclic GMP, Ignarro read a paper by Ferid Murad, who demonstrated that nitric oxide elevates cyclic GMP levels. Ignarro...

Kinase (SHK) Family TC# 9.B.34 - The Kinase/Phosphatase/Cyclic-GMP Synthase/Cyclic di-GMP Hydrolase (KPSH) Family The first identified substrates for the...

in IMP/GMP specific 5' nucleotidase, binding of one GMP molecule to a single subunit of the tetrameric enzyme leads to increased affinity for GMP by the...

(1999-10-29). "Serine 19 of Human 6-Pyruvoyltetrahydropterin Synthase Is Phosphorylated by cGMP Protein Kinase II". Journal of Biological Chemistry. 274 (44):...

Glycogen synthase kinase-3 beta, (GSK-3 beta), is an enzyme that in humans is encoded by the GSK3B gene. In mice, the enzyme is encoded by the Gsk3b gene...

monophosphate (IMP). IMP is then converted to either a precursor to AMP or GMP. Once AMP or GMP are formed, they can be phosphorylated by ATP to their diphosphate...

and cytokines stimulate the production of NO by endothelial nitric oxide synthase (eNOS). eNOS synthesizes NO from the terminal guanidine-nitrogen of L-arginine...

for impotence, which inhibits cGMP specific phosphodiesterase type 5 (PDE5), which is responsible for degradation of cGMP, which is produced by guanylate...

to activate STING through direct or indirect interactions. Cyclic GMP-AMP synthase (cGAS), which belongs to the nucleotidyltransferase family, is able...

One of the important targets for cellular reproduction is thymidylate synthase, which creates thymidine monophosphate (TMP) from deoxyuridine monophosphate...