GTP-binding protein regulators regulate G proteins in several different ways. Small GTPases act as molecular switches in signaling pathways, which act...

ability to bind guanosine triphosphate (GTP). Binding of GTP inherently changes the activity of the G proteins and increases their activity, through the...

Receptors stimulate GTP binding (turning the G protein on). RGS proteins stimulate GTP hydrolysis (creating GDP, thus turning the G protein off). All eukaryotes...

for nuclear transport and Rab and Arf for vesicle transport. GTP-binding protein regulators Wennerberg K, Rossman KL, Der CJ (March 2005). "The Ras superfamily...

triphosphate (GTP). As the name implies, Ras-GTPases possess intrinsic enzymatic activity that hydrolyses GTP to GDP and phosphate. Thus, upon binding to GTP, the...

RGS13, RGS14, RGS16, RGS17, RGS18, RGS19, RGS20, RGS21 SNX13 GTP-binding protein regulators: GEF GAP Coleman DE, Berghuis AM, Lee E, Linder ME, Gilman AG...

(GEFs) are proteins or protein domains that activate monomeric GTPases by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine...

factor) ability, which activates the G-protein by exchanging the GDP on the alpha subunit to GTP. The binding of GTP to the alpha subunit results in a structural...

gtp-binding protein alpha subunit, gi2 MeSH D12.776.476.375.100.300 – gtp-binding protein alpha subunits, gq-g11 MeSH D12.776.476.375.100.400 – gtp-binding...

(GTP) and hydrolyze it to guanosine diphosphate (GDP). The GTP binding and hydrolysis takes place in the highly conserved P-loop "G domain", a protein...

Nuclear protein) also known as GTP-binding nuclear protein Ran is a protein that in humans is encoded by the RAN gene. Ran is a small 25 kDa protein that...

proteins (GAPs). As per its classification, Ras has an intrinsic GTPase activity, which means that the protein on its own will hydrolyze a bound GTP molecule...

RNA-binding attenuation protein (TRAP protein) in species of Bacillus and related bacteria. This protein is encoded by the MtrB gene. TRAP protein forms...

function as regulators of vesicular traffic and actin remodelling. The small ADP ribosylation factor (Arf) GTP-binding proteins are major regulators of vesicle...

an associated G protein by exchanging the GDP bound to the G protein for a GTP. The G protein's α subunit, together with the bound GTP, can then dissociate...

to RanGTP, displaces Importin-α from the cargo. The NLS-protein is thus free in the nucleoplasm. The Importinβ-RanGTP and Importinα-CAS-RanGTP complex...

the uptake systems also have an extracytoplasmic receptor, a solute binding protein. Some homologous ATPases function in non-transport-related processes...

whether the allosteric sites are functional. The allosteric regulators of GLUD1 - ADP, GTP, Leu, NAD+ and NADH - exert their effects by changing the energy...

protein's activity, either enhancing or inhibiting its function. In contrast, substances that bind directly to an enzyme's active site or the binding...

mostly identical, with the N-terminal containing most of the protein coding for GTP binding and hydrolysis. The C-terminal of RhoA is modified via prenylation...

release and GTP binding to specific Small GTPases of the Rho family (e.g., Rac and Cdc42), leading to their activation since Rho proteins are inactive...

PMC 2665304. PMID 17035353. Bustelo XR, Sauzeau V, Berenjeno IM (2007). "GTP-binding proteins of the Rho/Rac family: regulation, effectors and functions in vivo"...

hemoglobin-like proteins whose known and predicted roles include the reversible binding of gaseous ligands. Since many of these proteins contain globins...

Calcium-binding proteins are proteins that participate in calcium cell signaling pathways by binding to Ca2+, the calcium ion that plays an important role...

mutagenesis has shown these regions to play a critical role in the binding of Rab proteins. Dirac-Svejstrup AB, Sumizawa T, Pfeffer SR (February 1997). "Identification...

eukaryotic translation initiation. eIF2 mediates the binding of tRNAiMet to the ribosome in a GTP-dependent manner. eIF2 is a heterotrimer consisting of...

activating protein (IQGAP) is a carrier protein. It is associated with the Rho GTP-binding protein. IQGAP1, IQGAP2, IQGAP3 IQ calmodulin-binding motif v...

an associated G protein by exchanging the GDP bound to the G protein for a GTP. The G protein's α subunit, together with the bound GTP, can then dissociate...

Dedicator of cytokinesis protein 5 (Dock5) is a large (~180 kDa) protein encoded in the human by the DOCK5 gene, involved in intracellular signalling...

Collybistin is a brain specific protein identified as a regulator of the localization of gephyrin, inducing the formation of submembrane gephyrin aggregates...