Genome instability (also genetic instability or genomic instability) refers to a high frequency of mutations within the genome of a cellular lineage. These...

usually has genome instability. This instability is likely due to reduced DNA repair or excessive DNA damage. Because of such instability, the cancer...

Chromosomal instability (CIN) is a type of genomic instability in which chromosomes are unstable, such that either whole chromosomes or parts of chromosomes...

Whole genome sequencing (WGS), also known as full genome sequencing or just genome sequencing, is the process of determining the entirety of the DNA sequence...

shrank in size and 40% grew in size. Cancers are known to exhibit genome instability or a "mutator phenotype". The protein-coding DNA within the nucleus...

of oncogenes, or difficult-to-replicate genome structures. Replication stress can lead to genome instability, cancer, and ageing. Uncoordinated...

Malignant tumors are also characterized by genome instability, so that cancers, as assessed by whole genome sequencing, frequently have between 10,000...

activating invasion and metastasis. Underlying these hallmarks are genome instability, which generates the genetic diversity that expedites their acquisition...

into three categories as below: Primary hallmarks (causes of damage) Genome instability Telomere shortening (or telomere attrition) Epigenetic alterations...

published by Impact Journals (Albany, New York). Genome instability, i.e., the tendency of the genome to acquire mutations and epimutations, underlies...

expression of SMC1B can cause DNA damage repair to fail that then causes genome instability. Expression of SMC1B higher or lower than normal is associated with...

pair with each other). These properties play an important role in genome instability and contribute not only to cellular evolution and genetic diversity...

also takes part in DNA repair. The down-regulation of SMC1A causes genome instability, and CdLS cells carrying SMC1A variants display high level of chromosome...

and the fetus. It has been shown that radiation damage including genome instability and carcinogenesis may occur transgenerationally in both males and...

inadequate number of centrosomes is very often linked to the appearance of genome instability and the loss of tissue differentiation. However, the method to count...

developmental processes. PRC-mediated epigenetic aberrations are linked to genome instability and malignancy and play a role in the DNA damage response, DNA repair...

or flawed anaphase checkpoint genes. Micronuclei can contribute to genome instability by promoting a catastrophic mutational event called chromothripsis...

lung cancer. Cellular DNA integrity is often compromised in cancer. Genome instability can refer to the accumulation of extra copies of DNA/chromosomes,...

patients have a 1-2% risk of developing distal gastric cancer. Genomic instability through various means such as DNA damage and epigenetic modifications...

PMID 22567193. Lim; et al. (2016). "Nuclear envelope rupture drives genome instability in cancer". Molecular Biology of the Cell. 27 (21). MBoC: 3210–3213...

processes. Defects in histone variant regulation have been linked to genome instability, a hallmark of many cancers and age-related diseases. Recent data...

Endonuclease 1 promotes 5′-flap specificity and incision to prevent genome instability". Nature Communications (8): 15. doi:10.1038/ncomms15855. PMC 5490271...

thousands of times across the genome. Microsatellites are also known as simple sequence repeats (SSRs). Microsatellite instability structure consists of repeated...

Dzhokhadze, TA; Buadze, TZh; Rubanov, KD; Kiriia, NA; Lezhava, TA (2013). "Genome instability in pulmonary tuberculosis before and after treatment". Georgian Med...

Fz seven-transmembrane receptor family have been described in the human genome. As a result, a large variety of responses could be initiated from the Wnt/Fz...

reactivation (which can be due to chemotherapy or radiation) can result in genome instability and cancer. In the case of herpes simplex (HSV), the virus has been...

(born September 29, 1956) is a Russian-American biologist who studies genome instability mediated by repetitive DNA during DNA replication and transcription...

HH, Goodier JL (August 2002). "LINE drive. retrotransposition and genome instability". Cell. 110 (3): 277–80. doi:10.1016/S0092-8674(02)00868-1. PMID 12176313...

breakage when genome replication becomes blocked or stalled, helping to explain why BRCA2-deficient cells spontaneously exhibit genome instability during cell...

PMID 16668285. Storchova Z, Pellman D (2004). "From polyploidy to aneuploidy, genome instability and cancer". Nature Reviews Molecular Cell Biology. 5 (1): 45–54....