• A helix bundle is a small protein fold composed of several alpha helices that are usually nearly parallel or antiparallel to each other. Three-helix bundles...
    6 KB (629 words) - 21:04, 20 April 2025
  • Thumbnail for Alpha helix
    An alpha helix (or α-helix) is a sequence of amino acids in a protein that are twisted into a coil (a helix). The alpha helix is the most common structural...
    46 KB (5,204 words) - 13:21, 31 March 2025
  • Thumbnail for SNARE protein
    {\displaystyle \alpha } -helix bundle, where one α {\displaystyle \alpha } -helix is contributed by syntaxin 1, one α {\displaystyle \alpha } -helix by synaptobrevin...
    54 KB (6,592 words) - 13:34, 24 May 2025
  • Thumbnail for Rop protein
    Structurally, Rop is a homodimeric four-helix bundle protein formed by the antiparallel interaction of two helix-turn-helix monomers. The Rop protein's structure...
    3 KB (264 words) - 07:38, 18 August 2023
  • of a helix hairpin is unknown; however, a four helix bundle is composed of two helix hairpins, which have important ligand binding sites. A helix corner...
    7 KB (804 words) - 08:29, 8 May 2025
  • Thumbnail for Villin-1
    the C-terminus consisting of a fast and independently folding three-helix bundle that is stabilized by hydrophobic interactions. The headpiece domain...
    9 KB (1,108 words) - 08:33, 17 October 2022
  • Thumbnail for Basic helix–loop–helix
    crystallize bHLH proteins bound to E-boxes, demonstrating that the parallel 4-helix bundle motif loop orients the basic sequences to interact with specific nucleotides...
    14 KB (1,402 words) - 16:06, 27 March 2025
  • Thumbnail for Protein A
    composed of five homologous Ig-binding domains that fold into a three-helix bundle. Each domain is able to bind proteins from many mammalian species, most...
    17 KB (1,860 words) - 10:05, 20 May 2024
  • Thumbnail for Adnaviria
    major capsid protein (MCP) that contains the SIRV2 fold, a type of alpha-helix bundle containing four helices. The virion consists of the genome encased in...
    15 KB (1,666 words) - 22:27, 28 March 2025
  • Thumbnail for Theories of general anaesthetic action
    Dutton PL (1998). "A designed cavity in the hydrophobic core of a four-α-helix bundle improves volatile anesthetic binding affinity". Biochemistry. 37 (5):...
    63 KB (6,829 words) - 22:27, 27 May 2025
  • Thumbnail for Cyclic nucleotide–gated ion channel
    as an alpha helix and exists as an uncoiled strand. Helices that cover the inner membrane line the channel. These also form a 6 helix bundle that signifies...
    39 KB (4,917 words) - 18:22, 22 December 2024
  • Thumbnail for BamHI
    parallel 4 helix bundle. This bundle marks the BamHI dimer interface, and it is thought that the dipole moments of the NH2-terminal atoms on this bundle may...
    9 KB (1,223 words) - 20:56, 30 May 2025
  • Thumbnail for Hemoprotein
    Robertson DE, DeGrado WF (1994-02-01). "Design of a heme-binding four-helix bundle". Journal of the American Chemical Society. 116 (3): 856–865. doi:10...
    22 KB (2,454 words) - 21:02, 23 May 2025
  • Thumbnail for Coronavirus spike protein
    a six-helix bundle, a characteristic feature of the class I fusion proteins. The S2 region is also considered to include the transmembrane helix and C-terminal...
    76 KB (7,519 words) - 19:42, 15 April 2025
  • Thumbnail for UBA protein domain
    motif of approximately 45 amino acid residues. They fold into three-helix bundle structures. The human homologue of yeast Rad23A is one example of a nucleotide...
    8 KB (787 words) - 13:58, 10 September 2024
  • Thumbnail for Helix-turn-helix
    Helix-turn-helix is a DNA-binding domain (DBD). The helix-turn-helix (HTH) is a major structural motif capable of binding DNA. Each monomer incorporates...
    24 KB (1,426 words) - 06:07, 30 December 2024
  • Thumbnail for Luciferase
    their association with the vacuolar membrane. The helical bundle domain has a three helix bundle structure that holds four important histidines that are...
    31 KB (3,253 words) - 05:32, 2 June 2025
  • composed of alpha helices and lack disulfide bridges. The parent three-helix bundle structure is currently the fastest folding protein structure known. Specific...
    20 KB (2,394 words) - 13:31, 13 April 2025
  • Thumbnail for Spectrin repeat
    and more recently the plakin family. The spectrin repeat forms a three-helix bundle. These conform to the rules of the heptad repeat. Spectrin repeats give...
    4 KB (396 words) - 04:30, 25 April 2025
  • four-helix bundle. Variations in osmolality trigger conformational changes in EnvZ which have been localized to the cytoplasmic four-helix bundle and which...
    8 KB (928 words) - 14:05, 7 July 2024
  • Thumbnail for Oncostatin M
    solved to atomic resolution, confirming the predicted long chain four helix bundle topology. Comparing this structure with the known structures of other...
    32 KB (4,317 words) - 12:20, 2 November 2024
  • Thumbnail for Archaeal virus
    fold, a type of alpha-helix bundle, and the MCPs of bicaudaviruses possess the ATV-like fold, another type of alpha-helix bundle. The architectural classes...
    51 KB (6,431 words) - 13:36, 28 May 2025
  • Thumbnail for Globin
    significantly steeper than other helical packings such as the helix bundle. The exact angle of helix packing depends on the sequence of the protein, because...
    19 KB (2,067 words) - 22:39, 2 November 2024
  • Thumbnail for Histidine phosphotransfer domain
    two different architectures, both composed of a four-helix bundle but differing in the way the bundle is assembled. Most structurally characterized HPt proteins...
    13 KB (1,324 words) - 04:13, 29 November 2023
  • of IL2 comprises a bundle of 4 helices (termed A-D), flanked by 2 shorter helices and several poorly defined loops. Residues in helix A, and in the loop...
    45 KB (4,194 words) - 12:36, 2 May 2024
  • Thumbnail for Apolipoprotein E
    The N-terminal region (residues 1–167) forms an anti-parallel four-helix bundle such that the non-polar sides face inside the protein. Meanwhile, the...
    59 KB (6,578 words) - 03:22, 24 May 2025
  • Thumbnail for Interleukin 4
    disulphide bonds. One half of the structure is dominated by a 4 alpha-helix bundle with a left-handed twist. The helices are anti-parallel, with 2 overhand...
    19 KB (2,297 words) - 02:04, 25 May 2025
  • Thumbnail for Collagen helix
    hydroxyproline. Collagen folded into a triple helix is known as tropocollagen. Collagen triple helices are often bundled into fibrils which themselves form larger...
    6 KB (623 words) - 16:23, 7 April 2024
  • Thumbnail for EcoRI
    complex, two α-helices from each subunit come together to form a four-helix bundle. On the interacting helices are residues Glu144 and Arg145, which interact...
    8 KB (891 words) - 05:50, 8 February 2025
  • Thumbnail for L27 domain
    to form a tight, four-helix bundle in the heterodimer, whilst the third helix of each L27_2 domain forms another four-helix bundle that assembles the two...
    6 KB (594 words) - 16:49, 12 May 2024