Microglia are a type of glial cell located throughout the brain and spinal cord of the central nervous system (CNS). Microglia account for about around...

Microglia are the primary immune cells of the central nervous system, similar to peripheral macrophages. They respond to pathogens and injury by changing...

oligodendrocytes (that produce myelin), astrocytes, ependymal cells and microglia, and in the peripheral nervous system they include Schwann cells (that...

hypertrophy of several different types of glial cells, including astrocytes, microglia, and oligodendrocytes. In its most extreme form, the proliferation associated...

these extrinsic cues for microglia, and microglia themselves may produce proteins that amplify the response. The effect of microglia on neurons that leads...

at Boston Children’s Hospital. She has helped to identify the role of microglia and complement proteins in the "pruning" or removal of synaptic cells...

productive cytotoxic effector cells that are capable of lysing tumor cells Microglia, a glial effector cell that reconstructs the Central nervous system after...

the central nervous system (CNS), including the brain and spinal cord, microglia are the resident innate immune cells that are activated in response to...

pancreatic stellate cells, dendritic cells, oligodendrocytes, and others. Microglia, which are notably smaller than macroglia, can also extend their end-processes...

anti-inflammatory states, microglia have also been shown to be able to assist in remyelination & subsequent neuron repair. As such, microglia are thought to be...

ATP has been shown to be a critically important signalling molecule for microglia - neuron interactions in the adult brain, as well as during brain development...

such as monocytes, macrophages, osteoclasts, myeloid dendritic cells, microglia, and Paneth cells. CSF1R expression is controlled by two alternative promoters...

have also been linked to allodynia. For example, there are reports that microglia in the thalamus might contribute to allodynia by changing the properties...

expression of genes associated with glial (e.g., astrocytes) and immune (e.g., microglia) cells, correlating with higher numbers of these cells in postmortem brain...

macroglia—astrocytes, ependymal cells, and oligodendrocytes, and much smaller microglia which are the macrophages of the central nervous system. Astrocytes are...

disorders. Within the brain, quinolinic acid is only produced by activated microglia and macrophages. In 1949 L. Henderson was one of the earliest to describe...

function. Neuroglial cells are classified as follows: Microglial cells: Microglia are macrophage cells that make up the primary immune system for the CNS...

communicate with microglia, the brain's main immune cells via specialized contact sites, called "somatic junctions". These connections enable microglia to constantly...

causes of a cytokine storm. The cells of the central nervous system, the microglia, neurons, and astrocytes, are also involved in the release of pro-inflammatory...

matter of the brain. Degenerative neuronal elements and an abundance of microglia and astrocytes can be associated with amyloid plaques. Some plaques occur...

neuroinflammation is the microglia. Microglia are recognized as the innate immune cells of the central nervous system. Microglia actively survey their environment...

Alzheimer's disease. Evidence has accrued for microglia as central actors in the mechanism of AD. Microglia are topographically associated with pTau and...

response in microglia and can cause neuroinflammation. SSRIs inhibit proinflammatory cytokine production, which leads to less activation of microglia and peripheral...

explores the diversity of microglia that exist within the basal ganglia circuitry to one day target regional or circuit-specific microglia in disease. De Biase's...

macrophages, immature monocyte-derived dendritic cells, osteoclasts, and microglia, which are immune cells in the central nervous system. In the liver, TREM2...

Río Hortega (1882 – 1945) was a Spanish neuroscientist who discovered microglia. Río Hortega was born in Portillo, Valladolid on 5 May 1882. He studied...

healthy controls, suggesting upregulated microglia-induced synaptic pruning in these individuals. Microglia-mediated synaptic pruning has also been observed...

by activated microglia. In a murine model of JE, it was found that in the hippocampus and the striatum, the number of activated microglia was more than...

cell proliferation and mitogen-activated protein kinase activation in microglia, but without producing any psychoactive or sedative effects. Abn-CBD can...

sarcopenia, and aging-associated diseases. Senescent astrocytes and microglia contribute to neurodegeneration. Mechanistically, replicative senescence...