mutagens. Three excision repair pathways exist to repair single stranded DNA damage: Nucleotide excision repair (NER), base excision repair (BER), and DNA...
33 KB (3,623 words) - 18:02, 20 August 2024
non-helix-distorting base lesions from the genome. The related nucleotide excision repair pathway repairs bulky helix-distorting lesions. BER is important for removing...
29 KB (3,493 words) - 01:31, 15 January 2025
ERCC2 (redirect from Excision repair cross-complementing rodent repair deficiency)
factor IIH (TFIIH) core complex involved in transcription-coupled nucleotide excision repair. Along with XPB, XPD is a part of human transcriptional initiation...
15 KB (1,846 words) - 16:57, 27 August 2024
mechanisms (base excision repair (BER), nucleotide excision repair (NER), DNA mismatch repair (MMR), homologous recombination repair (HR), non-homologous...
132 KB (16,176 words) - 11:20, 23 April 2025
Nuclease (section Nucleotide excision repair)
base excision repair. These AP sites are removed by AP endonucleases, which effect single strand breaks around the site. Nucleotide excision repair, not...
22 KB (2,538 words) - 09:39, 13 February 2025
ERCC1 (section Nucleotide excision repair)
DNA nucleotide excision repair (NER). The ERCC1-XPF nuclease also functions in pathways to repair double-strand breaks in DNA, and in the repair of “crosslink”...
46 KB (5,503 words) - 04:10, 17 March 2025
Hormesis (section Nucleotide excision repair)
by the DNA nucleotide excision repair (NER) pathway. Lymphocytes from GWI veterans exhibited a significantly elevated level of NER repair. It was suggested...
33 KB (3,634 words) - 07:52, 18 May 2025
DNA damage theory of aging (redirect from Errors and repairs theory of aging)
Mouse models of nucleotide-excision–repair syndromes reveal a striking correlation between the degree to which specific DNA repair pathways are compromised...
97 KB (11,163 words) - 08:06, 6 January 2025
RNF8 (section RNF8 in Nucleotide Excision Repair)
lead to cell death unless the lesions are repaired. Most repair of these lesions is by nucleotide excision repair. After UV-irradiation, RNF8 is recruited...
18 KB (2,260 words) - 23:27, 11 February 2025
ERCC4 (section Nucleotide excision repair (NER))
are partners during DNA repair. The ERCC1-XPF nuclease is an essential activity in the pathway of DNA nucleotide excision repair (NER). The ERCC1-XPF nuclease...
27 KB (3,315 words) - 00:33, 27 January 2024
good correlation between nucleotide excision repair capacity and life span. The association between nucleotide excision repair capability and longevity...
48 KB (5,541 words) - 13:32, 30 April 2025
exposure to UV light is repaired by nucleotide excision repair. In people with xeroderma pigmentosum, this damage is not repaired. As more abnormalities...
30 KB (3,013 words) - 19:58, 29 October 2024
in animal models. It induces DNA lesions usually corrected by nucleotide excision repair. 4-nitroquinoline 1-oxide (4NQO) is a quinoline, a carcinogenic...
8 KB (765 words) - 14:06, 26 September 2024
Pyrimidine dimer (category DNA replication and repair-deficiency disorders)
typically rectified promptly through DNA repair, such as through photolyase reactivation or nucleotide excision repair, with the latter being prevalent in...
16 KB (1,947 words) - 15:06, 24 November 2024
(2016). "Transcriptional and Posttranslational Regulation of Nucleotide Excision Repair: The Guardian of the Genome against Ultraviolet Radiation". Int...
43 KB (3,770 words) - 18:03, 27 November 2024
DSB repair occurs through a variety of different pathways and mechanisms in order to correctly repair these errors. Nucleotide excision repair is one...
29 KB (3,552 words) - 17:53, 31 October 2024
DNA damage (naturally occurring) (category DNA repair)
Cornerstone of DNA Repair-Targeted Therapies". Oncology. 31 (4): 265–73. PMID 28412778. Schärer OD (October 2013). "Nucleotide excision repair in eukaryotes"...
81 KB (10,123 words) - 21:20, 10 May 2025
Benzo(a)pyrene (section Nucleotide excision repair)
adducts can be efficiently eliminated from DNA by the process of nucleotide excision repair. Those adducts that are not removed can cause errors during DNA...
28 KB (2,662 words) - 03:27, 11 March 2025
seven different mammalian species to carry out DNA repair. They found that nucleotide excision repair capability increased systematically with species longevity...
24 KB (2,943 words) - 01:37, 21 March 2025
Progeroid syndromes (section Defects in DNA repair)
type). Nucleotide excision repair is a DNA repair mechanism. There are three excision repair pathways: nucleotide excision repair (NER), base excision repair...
74 KB (8,748 words) - 15:14, 24 November 2024
for their mechanistic studies of DNA repair. He has made contributions on photolyase and nucleotide excision repair in bacteria that have changed his field...
28 KB (2,569 words) - 02:17, 2 May 2025
ERCC6 (section DNA repair)
DNA excision repair protein ERCC-6 (also CS-B protein) is a protein that in humans is encoded by the ERCC6 gene. The ERCC6 gene is located on the long...
25 KB (3,274 words) - 22:19, 28 January 2023
CHD1L (section In DNA repair)
repair. CHD1L (ALC1) is also required for repair of UV-damaged chromatin through nucleotide excision repair. 1q21.1 deletion syndrome 1q21.1 duplication...
12 KB (1,501 words) - 23:08, 1 November 2024
agents. It inhibits the DNA replication of cells deficient in nucleotide excision repair in culture. Irofulven is an analogue of illudin S, a sesquiterpene...
11 KB (1,042 words) - 01:05, 1 April 2025
Proliferating cell nuclear antigen (category DNA repair)
chaperone Histone deacetylase Mismatch repair enzymes Licensing factor NKp44 receptor Nucleotide excision repair enzyme Poly ADP ribose polymerase Procaspases...
55 KB (6,180 words) - 10:18, 9 May 2025
Transcription factor II H (section DNA repair)
roles in transcription of various protein-coding genes and DNA nucleotide excision repair (NER) pathways. TFIIH first came to light in 1989 when general...
11 KB (1,203 words) - 14:43, 29 April 2025
UVC radiation doses due to the presence of the bacteria-like nucleotide excision repair genes uvrA, uvrB and uvrC (that encode the UvrABC endonuclease)...
2 KB (176 words) - 00:32, 2 April 2025
endonuclease that incises DNA at the 3’ side of the damaged nucleotide during nucleotide excision repair. Mutational defects in the Ercc5(Xpg) gene can cause...
12 KB (1,408 words) - 15:51, 29 March 2024
multi-subunit transcription repair factor IIH(TFIIH). TFIIH plays a key role in a major DNA repair process, nucleotide excision repair (NER), by opening the...
4 KB (529 words) - 00:32, 2 December 2023
portal Base excision repair Nucleotide excision repair Iyer RR, Pluciennik A, Burdett V, Modrich PL (February 2006). "DNA mismatch repair: functions and...
37 KB (4,458 words) - 00:33, 14 May 2025