known as pituitary homeobox 2 is a protein that in humans is encoded by the PITX2 gene. This gene encodes a member of the RIEG/PITX homeobox family, which...

The genes that have been identified in approximately 50% of cases are PITX2 and FOXC1. Given the important hereditary factor, it is important to evaluate...

and LEFTY2 that activate PITX2 to signal the development of left side structures. Whereas, the right side does not express PITX2 and consequently develops...

syndrome is inherited in an autosomal dominant fashion and is associated with PITX2 or FOXC1. The total prevalence of glaucoma is about the same in North America...

Pagán-Westphal SM, Smith DM, Paganessi L, Tabin CJ (1998). "The transcription factor Pitx2 mediates situs-specific morphogenesis in response to left-right asymmetric...

genes that encode transcription factors, such as TBX3 and TBX5, NKX2-5 or PITX2, involved in the regulation of cardiac conduction, modulation of ion channels...

where it activates a further signalling cascade of genes including Nodal, Pitx2 and Lefty2. In chickens, LR asymmetry is established at a structure called...

PDX1 MODY 4 LMX1B Nail–patella syndrome MSX1 Tooth and nail syndrome OFC5 PITX2 Axenfeld syndrome 1 POU4F3 DFNA15 POU3F4 DFNX2 ZEB1 Posterior polymorphous...

regulators. In this review, the role of the anterior segment dysgenesis genes PITX2 and FOXC1 is considered in relation to the embryology of the anterior segment...

000,000 Ataxia telangiectasia ATM 1:40,000-1,000,000 Axenfeld syndrome PITX2, FOXO1A, FOXC1, PAX6 1:200,000 Bainbridge–Ropers syndrome ASXL3 de novo...

CRX; PAX2, PAX3, PAX4, PAX5, PAX6, PAX7, PAX8; PHOX2A, PHOX2B; PITX1, PITX2, PITX3; PROP1; PRRX1, PRRX2; RAX, RAX2; RHOXF1, RHOXF2/2B; SEBOX; SHOX,...

develop in the presence of either Tbx4 or Tbx5. In fact, it is the Pitx1 and Pitx2 genes that appears to be necessary for specification of the developing hindlimb...

SHOX2 - Measurement in lung fluid to aid in diagnosis of lung cancer. PITX2 - Measurement in prostate tissue as a prognosis factor for prostate cancer...

Q9BZ71 12200 PITRM1 HGNC:17663 Q5JRX3 12201 PITX1 HGNC:9004 P78337 12202 PITX2 HGNC:9005 Q99697 12203 PITX3 HGNC:9006 O75364 12204 PIWIL1 HGNC:9007 Q96J94...

ENSG00000069011 Homeodomain Known motif – High-throughput in vitro [699] HTAATCC PITX2 ENSG00000164093 Homeodomain Known motif – High-throughput in vitro [700]...

with transcription factor coding-genes, such as TBX3 and TBX5, NKX2-5 o PITX2, which are involved in cardiac conduction regulation, in ionic channel modulation...

Hitoshi; Shimozato, Kazuo; Matsumoto, Naomichi (2014-07-31). "A novel PITX2 mutation causing iris hypoplasia". Human Genome Variation. 1 (1): 14005...

mutation in PITX2 a regulatory protein of the FOXJ1 gene. PITX2 alongside LEF-1 and β-Catenin regulate FOXJ1. FOXJ1 in turn interacts with PITX2 to form a...

Other genes such as MSX1, PAX9, IRF6, GREM2, AXIN2, LRP6, SMOC2, LTBP3, PITX2, and WNT10B. The WNT10A gene is considered to be the major gene involved...

Hoonaard TL, Gischler SJ (February 2008). "Exclusion of a PAX6, FOXC1, PITX2, and MYCN mutation in another patient with apple peel intestinal atresia...

PDX1 MODY 4 LMX1B Nail–patella syndrome MSX1 Tooth and nail syndrome OFC5 PITX2 Axenfeld syndrome 1 POU4F3 DFNA15 POU3F4 DFNX2 ZEB1 Posterior polymorphous...

PDX1 MODY 4 LMX1B Nail–patella syndrome MSX1 Tooth and nail syndrome OFC5 PITX2 Axenfeld syndrome 1 POU4F3 DFNA15 POU3F4 DFNX2 ZEB1 Posterior polymorphous...

tooth formation include BMP4, FGF8, and homeobox genes such as MSX1, PAX9, PITX2, SHOX2, Barx1, and Shh to name a few. Research suggests that homeobox genes...

Studies on the nodal signaling pathway and its downstream targets such as PITX2 in other animals have shown it may also control left-right asymmetric patterning...

Smith, D. M.; Paganessi, L; Tabin, C. J. (1998). "The transcription factor Pitx2 mediates situs-specific morphogenesis in response to left-right asymmetric...

associated with pathogenic mutations in DCN, DSPG3, FOXC1, KERA, LUM, or PITX2". Ophthalmic Genet. 28 (2): 57–67. doi:10.1080/13816810701351321. PMID 17558846...

functions of BMP signaling, Wnt signaling, and the transcription factor Pitx2 in the regulation of heart, craniofacial, and limb development in mice....

Russo AF (1998). "The molecular basis of Rieger syndrome. Analysis of Pitx2 homeodomain protein activities". J. Biol. Chem. 273 (32): 20066–72. doi:10...

Amendt BA, Sutherland LB, Russo AF (1999). "Multifunctional role of the Pitx2 homeodomain protein C-terminal tail". Molecular and Cellular Biology. 19...

phosphorylation modulates N- and C-terminal regulatory activities of the PITX2 homeodomain protein". Biochemistry. 44 (10): 3942–54. doi:10.1021/bi048362x...