The prothrombinase enzyme complex consists of factor Xa (a serine protease) and factor Va (a protein cofactor). The complex assembles on negatively charged...

optimized when factor Xa is complexed with activated co-factor V in the prothrombinase complex. Factor Xa is inactivated by protein Z-dependent protease inhibitor...

F2-gene. It is proteolytically cleaved during the clotting process by the prothrombinase enzyme complex to form thrombin. Thrombin (Factor IIa) (EC 3.4.21.5...

factor pathway inhibitor (TFPI). FXa and its co-factor FVa form the prothrombinase complex, which activates prothrombin to thrombin. Thrombin then activates...

and cardiac arrest. One of the main components of the venom is the prothrombinase complex pseutarin-C, which breaks down prothrombin. John White, the...

coagulation, uninhibited factor Xa forms a prothrombinase complex with factor Va on platelet surfaces. Prothrombinases turn prothrombins to thrombins. Thrombins...

Quinn-Allen, M. A.; Kane, W. H.; Lentz, B. R. (2011). "Modulation of Prothrombinase Assembly and Activity by Phosphatidylethanolamine". Journal of Biological...

platelet membrane surface. These phospholipids then bind the tenase and prothrombinase complexes, two of the sites of interplay between platelets and the coagulation...

AndexXa. Rivaroxaban inhibits both free and bound Factor Xa in the prothrombinase complex. It is a selective direct factor Xa inhibitor with an onset...

X activators, and anticoagulant activities (including inhibitors of prothrombinase complex formation, inhibitors of thrombin, phospholipases, and protein...

prothrombin to thrombin, such as factor VIIIa-IXa (tenase) and factor Va-Xa (prothrombinase). In Scott syndrome, the mechanism for translocating PS to the platelet...

The thereby activated factor V (now called FVa) is a cofactor of the prothrombinase complex: The activated factor X (FXa) enzyme requires calcium and activated...

two distinct exosites is required for activation of prothrombin by prothrombinase". Journal of Thrombosis and Haemostasis. 1 (Supplement 1). Archived...

vivo cleavage of prothrombin into thrombin (factor IIa) by the enzyme prothrombinase (a complex of factor Xa and factor Va). It is released from the N-terminus...

Thrombin is produced from prothrombin, by the action of an enzyme, prothrombinase (Factor Xa along with Factor Va as a cofactor), in the final states...

both CD4+ and CD8+ T cells. Membrane bound FGL2 (mFGL2) exhibits a prothrombinase activity, resulting in fibrin deposition, vascular thrombosis and tissue...

Several enzyme complexes of blood coagulation cascade such as tenase and prothrombinase are activated by the cell surface exposure of the phosphatidylserine...

1993). "Binding of protein S to factor Va associated with inhibition of prothrombinase that is independent of activated protein C". The Journal of Biological...

intrinsic blood coagulation pathway. β2-GP1 causes a reduction of the prothrombinase binding sites on platelets and reduces the activation caused by collagen...

1 on Prothrombin with High Affinity and Inhibits Its Activation by Prothrombinase". Journal of Biological Chemistry. 281 (49): 37477–37485. doi:10.1074/jbc...

vomiting and diarrhoea as well as diaphoresis. The venom contains prothrombinase, a complex that prompts the production of the thrombin enzyme in the...

a crucial element in blood clotting; together they are part of the prothrombinase complex.: 26S  Cofactors in the inactivation of Factor Va and Factor...

EPR-1-like molecule in regulating factor Xa incorporation into platelet prothrombinase". Thromb. Haemost. 86 (4): 1133–5. doi:10.1055/s-0037-1616557. PMID 11686347...

Zwaal RF, Hemker HC: The role of phospholipids and factor Va in the prothrombinase complex. J Biol Chem 1980, 255:274-83. Bevers EM, Comfurius P, van Rijn...