The serotonin transporter (SERT or 5-HTT) also known as the sodium-dependent serotonin transporter and solute carrier family 6 member 4 is a protein that...
31 KB (3,442 words) - 02:06, 20 June 2025
PMAT has been identified as a low-affinity transporter, with an apparent Km of 114 micromoles/l for serotonin, which is approximately 230 times higher than...
173 KB (18,295 words) - 19:45, 2 June 2025
The three major classes are serotonin transporters (SERTs), dopamine transporters (DATs), and norepinephrine transporters (NETs) and are responsible for...
21 KB (2,342 words) - 15:34, 14 September 2024
blocking the action of the serotonin transporter (SERT). This in turn leads to increased extracellular concentrations of serotonin and, therefore, an increase...
11 KB (843 words) - 10:04, 13 March 2024
conditions. SSRIs primarily work by blocking serotonin reabsorption (reuptake) via the serotonin transporter, leading to gradual changes in brain signaling...
155 KB (16,550 words) - 01:34, 18 June 2025
serotonin transporter (SERT) and dopamine transporter (DAT), respectively. This in turn leads to increased extracellular concentrations of serotonin and...
16 KB (1,791 words) - 22:09, 29 May 2025
serotonin transporter (SERT) and noradrenaline transporter (NAT) are membrane transport proteins that are responsible for the reuptake of serotonin and noradrenaline...
84 KB (8,214 words) - 15:24, 9 June 2025
Reuptake enhancer (redirect from Selective serotonin reuptake enhancers)
Tianeptine has no affinity for the serotonin transporter, neither increases nor decreases extracellular levels of serotonin in cortico-limbic structures of...
4 KB (403 words) - 22:10, 12 January 2024
5-HTTLPR (serotonin-transporter-linked promoter region) is a degenerate repeat (redundancy in the genetic code) polymorphic region in SLC6A4, the gene...
37 KB (4,507 words) - 12:27, 18 February 2025
simultaneous inhibition of the serotonin transporter (SERT), norepinephrine transporter (NET), and dopamine transporter (DAT), respectively, increasing...
142 KB (16,594 words) - 16:53, 5 June 2025
Relatedly, genetic ablation of the serotonin transporter (SERT), which results in complete loss of SERT-mediated serotonin reuptake, is associated with 4-...
72 KB (8,007 words) - 11:26, 6 June 2025
proteins for monoamines (i.e., the dopamine transporter, norepinephrine transporter, and serotonin transporter) in monoamine neurons. Other VMAT2 inhibitors...
29 KB (3,347 words) - 14:46, 25 May 2025
Reuptake inhibitor (redirect from Transporter blocker)
on the serotonin transporter, they bind to an allosteric site, which exerts its effects by causing conformational changes in the transporter protein...
19 KB (1,917 words) - 07:07, 23 November 2024
Dapoxetine (category Selective serotonin reuptake inhibitors)
to 64 years old. Dapoxetine works by inhibiting the serotonin transporter, increasing serotonin's action at the postsynaptic cleft, and as a consequence...
28 KB (3,077 words) - 23:01, 2 May 2025
Dopamine reuptake inhibitor (redirect from Dopamine transporter "inverse agonist")
very selective for the dopamine transporter, with little to no effect on the norepinephrine and serotonin transporters 4-Hydroxy-1-methyl-4-(4-methylphenyl)-3-piperidyl...
19 KB (1,930 words) - 22:33, 23 May 2025
(SRI-20041) SRI-29574 SRI-31142 Monoamine transporter Norepinephrine transporter Serotonin transporter Glutamate transporter ENSG00000276996 GRCh38: Ensembl release...
84 KB (9,214 words) - 05:22, 22 June 2025
Reuptake (category Neurotransmitter transporters)
predicted topological organization of the serotonin transporter. In addition to neurotransmitter transporters, many other proteins in both animals and...
15 KB (1,897 words) - 08:15, 17 July 2024
transporters (MATs), which include the serotonin transporter (SERT), norepinephrine transporter (NET), and dopamine transporter (DAT). This in turn results in...
20 KB (1,388 words) - 21:36, 30 January 2025
candidate gene has reached genome-wide significance. The 5-HTTLPR, or serotonin transporter promoter gene's short allele, has been associated with increased...
128 KB (15,013 words) - 18:55, 22 May 2025
ylphenylsulfanyl)-benzonitrile, is a compound that binds to the serotonin transporter. Labeled with carbon-11 — a radioactive isotope — it has been used...
25 KB (2,038 words) - 04:00, 26 January 2024
Tianeptine (section Serotonin reuptake enhancer)
selective serotonin reuptake enhancer (SSRE) antidepressant. Tianeptine had been found to bind to the same allosteric site on the serotonin transporter (SERT)...
71 KB (6,476 words) - 01:11, 16 June 2025
inhibition of the serotonin transporter and PDE4. It promotes monoamine release through vesicular monoamine transporter-2 upregulation, with serotonin reuptake...
20 KB (2,126 words) - 10:15, 7 June 2025
serotonergic systems. Serotonin receptor and transporter binding studies have yielded conflicting results, including higher and lower serotonin receptor 5-HT2A...
171 KB (19,030 words) - 18:35, 17 June 2025
for the dopamine transporter (DAT) over the norepinephrine transporter (NET). Cocaine is also more potent in serotonin transporters (SERTs) than NDRI...
158 KB (14,532 words) - 17:12, 22 June 2025
the dopamine transporter (DAT), and 5,690 nM at the norepinephrine transporter (NET). 1Z2MAP1O's inhibition of the serotonin transporter (SERT) was not...
6 KB (242 words) - 16:31, 8 March 2025
the serotonin transporter-linked promoter region gene known as 5-HTTLPR, which is transcribed into a serotonin transporter that removes serotonin. It...
45 KB (5,499 words) - 07:48, 30 May 2025
norepinephrine transporter (NET) in the brain. Research has suggested that it also inhibits the reuptake of serotonin by binding to the selective serotonin transporter...
34 KB (3,810 words) - 10:31, 16 June 2025
Development and discovery of SSRI drugs (category Selective serotonin reuptake inhibitors)
primarily inhibit serotonin transporter (SERT) in the brain and have negligible effects on dopamine transporter (DAT) and norepinephrine transporter (NET). Inhibiting...
51 KB (5,336 words) - 14:09, 1 April 2025
Sertraline (category Selective serotonin reuptake inhibitors)
a selective serotonin reuptake inhibitor (SSRI). By binding to the serotonin transporter (SERT) it inhibits neuronal reuptake of serotonin and potentiates...
105 KB (10,802 words) - 20:53, 17 June 2025
inhibitory effects of propofol and ketamine on norepinephrine and serotonin transporter function". J Clin Neurosci. 15 (11): 1264–9. doi:10.1016/j.jocn...
119 KB (11,478 words) - 15:45, 21 June 2025