Siglecs (Sialic acid-binding immunoglobulin-type lectins) are cell surface proteins that bind sialic acid. They are found primarily on the surface of...

Sialoadhesin (SIGLEC-1) is a cell adhesion molecule found on the surface of various immune cells. It is found in especially high amounts on macrophages...

of the SIGLEC9 gene. Within the siglec family of transmembrane proteins, Siglec-8 belongs to the CD33-related siglec subfamily, a subfamily that has undergone...

They found that 9 of the 12 marketed Siglec-Fc reagents bind to HeLa cells, and two of which, Siglec-11 and Siglec-14, had binding that was vulnerable...

CD33 or Siglec-3 (sialic acid binding Ig-like lectin 3, SIGLEC3, SIGLEC-3, gp67, p67) is a transmembrane receptor expressed on cells of myeloid lineage...

the SIGLEC10 gene. Siglec-G is often referred to as the murine paralog of human Siglec-10 Like most but not all other Siglecs, Siglec-10 bears an ITIM (Immunoreceptor...

Myelin-associated glycoprotein (MAG), or Siglec-4 is a type 1 transmembrane protein, a glycoprotein localized in periaxonal Schwann cell and oligodendrocyte...

Sialic acid binding Ig-like lectin 15 (Siglec-15) is a protein that in humans is encoded by the SIGLEC15 gene. Siglec-15 is predominately expressed on osteoclasts...

a humanized, nonfucosylated IgG1 monoclonal antibody that targets Siglec-8. Siglec-8 is an inhibitory receptor present on eosinophils and mast cells,...

CD22, or cluster of differentiation-22, is a molecule belonging to the SIGLEC family of lectins. It is found on the surface of mature B cells and to a...

PMID 9373149. Cornish AL, Freeman S, Forbes G, et al. (1998). "Characterization of siglec-5, a novel glycoprotein expressed on myeloid cells related to CD33". Blood...

these osteoblasts can worsen tumors in two ways. First, they can induce SiglecFhigh-expressing neutrophil formation that in turn promotes lung tumor growth...

Vadastuximab talirine is an antibody-drug conjugate (ADC) directed to CD33 (siglec-3) which is a transmembrane receptor expressed on cells of myeloid lineage...

inhibitory receptor Siglec-11, but induces an opposing response through interactions with the paired activating receptor Siglec-16, exemplifying the...

mammalian glycan-binding proteins (GBPs): C-type lectin, galectin, and SIGLEC immune receptors that bind carbohydrates: CD1, T cell receptor, and anti-carbohydrate...

L1 (protein), CHL1, Neurofascin and NrCAM SIGLEC family including Myelin-associated glycoprotein (MAG, SIGLEC-4), CD22 and CD83 CTX family including CTX...

sixth member of the SIGLEC family of receptors to be identified. The protein has also been given the CD designation CD327. Siglec-6 was first found to...

S2CID 9762771. Lopez PH (2014). "Role of Myelin-Associated Glycoprotein (Siglec-4a) in the Nervous System". Glycobiology of the Nervous System. Advances...

Crocker PR (Dec 1999). "Identification and characterization of a novel siglec, siglec-7, expressed by human natural killer cells and monocytes". J Biol Chem...

characterization, and phylogenetic analysis of siglec-9, a new member of the CD33-related group of siglecs. Evidence for co-evolution with sialic acid synthesis...

an extracellular domain with a siglec-like immunoglobulin fold that substitutes hydrophobic interactions for the siglec fold's characteristic disulfide...

T-cell receptors such as CD2, CD4, CD80, and CD86; in the N-terminal part of Siglec-receptors, in myelin membrane adhesion molecules; in junctional adhesion...

CD8+T 2 HLA-E SHP-1, SHP-2 CD31 My, platelet, EC, T, NK 1 CD31 SHP-1, SHP-2 SIGLEC family Hm 1-4 Sialic acid SHP-1, SHP-2 CD66 Hm, EC 2 CD66 SHP-1, SHP-2 ILTs/LIRs...

PILR-associating neural protein (PANP), HSV-1 glycoprotein B PILRA, PILRB SIGLEC family Endogenous and pathogen-derived sialylated glycans SIGLEC1, SIGLEC8...

an extracellular domain with a siglec-like immunoglobulin fold that substitutes hydrophobic interactions for the siglec fold's characteristic disulfide...

polySia binds with Siglec-11 allowing for the regulation of microglia through exosomes. This shows that polySia binding with Siglec-11 causes a delay in...

MedlinePlus Overview bonecancer Wang Y, Zhan X, et al. (January 22, 2024). "Siglec-15/sialic acid axis as a central glyco-immune checkpoint in breast cancer...

PMC 3322476. PMID 19725119. Liu Y, Chen GY, Zheng P (December 2009). "CD24-Siglec G/10 discriminates danger- from pathogen-associated molecular patterns"...

charged carboxyl group at C1. Sialidosis Sialoglycoprotein Sialyltransferase Siglec Orthomyxoviridae Varki, Ajit; Roland Schauer (2008). "Sialic Acids". in...

AP; Rasmussen, HS; Rothenberg, ME; Hirano, I (22 October 2020). "Anti-Siglec-8 Antibody for Eosinophilic Gastritis and Duodenitis". The New England Journal...