Sphingosine-1-phosphate receptor modulators are a class of drugs that interact with S1P receptors, a family of G protein-coupled receptors involved in...
14 KB (1,551 words) - 07:53, 18 February 2025
The sphingosine-1-phosphate receptors are a class of G protein-coupled receptors that are targets of the lipid signalling molecule Sphingosine-1-phosphate...
12 KB (1,266 words) - 08:05, 18 August 2023
Sphingosine-1-phosphate (S1P) is a signaling sphingolipid, also known as lysosphingolipid. It is also referred to as a bioactive lipid mediator. Sphingolipids...
25 KB (2,659 words) - 11:24, 25 May 2025
formation of sphingosine-1-phosphate, a potent signaling lipid. Sphingolipid metabolites, such as ceramides, sphingosine and sphingosine-1-phosphate, are lipid...
4 KB (220 words) - 20:12, 19 July 2024
Fingolimod (category S1P receptor modulators)
used for the treatment of multiple sclerosis. Fingolimod is a sphingosine-1-phosphate receptor modulator, which sequesters lymphocytes in lymph nodes, preventing...
27 KB (2,587 words) - 23:10, 6 February 2025
Etrasimod (category S1P receptor modulators)
the treatment of ulcerative colitis. It is a selective sphingosine-1-phosphate (S1P) receptor modulator that modifies the activity of the immune system...
13 KB (811 words) - 02:32, 12 October 2024
S1PR1 (redirect from Sphingosine-1-phosphate receptor 1)
Sphingosine-1-phosphate receptor 1 (S1P receptor 1 or S1PR1), also known as endothelial differentiation gene 1 (EDG1) is a protein that in humans is encoded...
21 KB (2,453 words) - 04:31, 12 February 2025
for the treatment of systemic lupus erythematosus. It is a sphingosine-1-phosphate receptor modulator. "Cenerimod - Idorsia Pharmaceuticals". AdisInsight...
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Ozanimod (category S1P receptor modulators)
relapsing multiple sclerosis and ulcerative colitis. It acts as a sphingosine-1-phosphate receptor (S1PR) agonist, sequestering lymphocytes to peripheral lymphoid...
34 KB (3,309 words) - 13:11, 13 April 2025
Siponimod (category S1P receptor modulators)
Siponimod, sold under the brand name Mayzent, is a selective sphingosine-1-phosphate receptor modulator for oral use that is used for multiple sclerosis...
11 KB (798 words) - 20:58, 10 October 2024
Etrasimod, a once-daily oral sphingosine 1-phosphate (S1P) receptor modulator that selectively activates S1P receptor subtypes 1, 4, and 5 with no detectable...
143 KB (16,281 words) - 12:26, 22 May 2025
protection by activated protein C through PAR1-dependent sphingosine 1-phosphate receptor-1 crossactivation". Blood. 105 (8): 3178–84. doi:10.1182/blood-2004-10-3985...
19 KB (2,285 words) - 10:53, 11 May 2024
rich in phosphatidate (PA), a product of phospholipase D (PLD). Sphingosine-1-phosphate (S1P) is a novel lipid messenger with both intracellular and extracellular...
9 KB (1,115 words) - 02:19, 27 May 2025
Ponesimod (category S1P receptor modulators)
medication for the treatment of multiple sclerosis. It is a sphingosine-1-phosphate receptor modulator. The most common side effects include upper respiratory...
15 KB (1,066 words) - 21:13, 1 November 2024
SPHK2 (redirect from Sphingosine kinase 2)
isozymes that catalyze the phosphorylation of sphingosine into sphingosine 1-phosphate. Sphingosine 1-phosphate mediates many cellular processes including...
6 KB (715 words) - 16:10, 19 March 2024
Alternatively, palmitoyl-CoA is used as a substrate in the biosynthesis of sphingosine (this biosynthetic pathway does not require transfer into the mitochondria)...
7 KB (612 words) - 20:33, 15 September 2024
Lipid signaling (section Sphingosine-1-Phosphate)
L. M. (2004). "Sphingosine-1-phosphate receptors: receptor specificity versus functional redundancy". Biochim. Biophys. Acta. 1682 (1–3): 48–55. doi:10...
55 KB (5,633 words) - 08:40, 12 July 2024
releasing factor type 1 receptor Sphingosine-1-phosphate receptors EDG1, EDG3 and EDG5 Muscarinic acetylcholine receptor M3 Transient receptor potential TRPC1...
25 KB (3,064 words) - 08:30, 25 March 2025
Lysophosphatidic acid (redirect from 1-acyl-sn-glycerol 3-phosphate)
synthesis of phosphatidic acids. Autotaxin GPR35 Phosphatidic acid Sphingosine-1-phosphate Gintonin van Corven, Emile J.; Groenink, Alida; Jalink, Kees; Eichholtz...
8 KB (717 words) - 23:37, 23 May 2025
Sphingosine kinase (SphK) is a conserved lipid kinase that catalyzes formation sphingosine-1-phosphate (S1P) from the precursor sphingolipid sphingosine...
6 KB (627 words) - 09:37, 14 December 2023
S1PR3 (category Transmembrane receptor stubs)
Sphingosine-1-phosphate receptor 3 also known as S1PR3 is a human gene which encodes a G protein-coupled receptor which binds the lipid signaling molecule...
8 KB (927 words) - 14:58, 28 May 2024
lysosome may then re-enter pathways for synthesis of ceramide and/or sphingosine-1-phosphate. The salvage pathway re-utilizes long-chain sphingoid bases to...
30 KB (3,370 words) - 22:02, 23 May 2025
3 (LPAR3) Sphingosine 1-phosphate receptor InterPro: IPR004061 Sphingosine 1-phosphate receptor 1 (S1PR1) Sphingosine 1-phosphate receptor 2 (S1PR2) Sphingosine...
25 KB (2,172 words) - 01:01, 29 November 2023
extracellular signaling molecules, lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P). The term lysophospholipid (LPL) refers to any phospholipid...
5 KB (476 words) - 07:56, 28 May 2025
Lysophosphatidylcholine (redirect from 1-acylglycerol-3-phosphocholine)
a carotid artery, which may have a detrimental impact on overall health. 1-Lysophosphatidylcholine Li X, Wang L, Fang P, et al. (May 2018). "Lysophospholipids...
11 KB (1,140 words) - 01:10, 25 May 2025
Arnatt CK, Spiegel S, Farr SA, Salvemini D (September 2022). "Sphingosine-1-phosphate receptor 1 activation in the central nervous system drives cisplatin-induced...
39 KB (3,839 words) - 05:29, 26 May 2025
Lysophosphatidic acid receptor 6 (LPAR6; formerly known as GPR87, P2RY5) Lysophospholipid receptor Sphingosine-1-phosphate receptor P2Y receptor v t e...
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S1PR4 (category Transmembrane receptor stubs)
Sphingosine-1-phosphate receptor 4 also known as S1PR4 is a human gene which encodes a G protein-coupled receptor which binds the lipid signaling molecule...
7 KB (830 words) - 22:49, 27 March 2024
GPR6 (redirect from G protein-coupled receptor 6)
transmembrane receptors. It has been reported that GPR6 is both constitutively active but in addition is further activated by sphingosine-1-phosphate. GPR6 up-regulates...
5 KB (475 words) - 20:46, 25 February 2025
sphingosine-1-phosphate receptors (S1P1-5), which are G protein-coupled receptors located in the cell membrane that bind to the ligand sphingosine-1-phosphate...
18 KB (2,275 words) - 23:06, 7 April 2025