1 (i.e. TAL1 but also termed stem cell leukemia/T-cell acute leukemia 1 [i.e. SCL/TAL1]) is a protein that in humans is encoded by the TAL1 gene. The...
11 KB (1,404 words) - 22:20, 22 August 2024
PMC 6513628. PMID 30080246. Ono Y, Fukuhara N, Yoshie O (December 1998). "TAL1 and LIM-only proteins synergistically induce retinaldehyde dehydrogenase...
33 KB (3,152 words) - 18:41, 25 April 2025
transcripts such as SIL-TAL1. Mutation of TAL1 is frequently present in T-ALL patients, where SIL/TAL1 fusion leads to inappropriate TAL1 expression, promoting...
24 KB (2,737 words) - 23:01, 25 May 2025
gene, LMO2 is disrupted. LMO1 has been shown to interact with GATA3 and TAL1. GRCh38: Ensembl release 89: ENSG00000166407 – Ensembl, May 2017 GRCm38:...
9 KB (1,258 words) - 20:36, 27 December 2023
factors containing a bHLH include: MyoD Myf5 Beta2/NeuroD1 Scl, also known as Tal1 proneural bHLH genes like p-CaMKII, and pSer(336)NeuroD. Neurogenins MAX...
14 KB (1,402 words) - 16:06, 27 March 2025
involve non-inherited mutations to PAX5 and IKZF1. In T-cell ALL, LYL1, TAL1, TLX1, and TLX3 rearrangements can occur. Acute lymphoblastic leukemia results...
82 KB (7,920 words) - 19:51, 29 May 2025
3390/cancers10040100. PMC 5923355. PMID 29614760. Ono Y, Fukuhara N, Yoshie O (Dec 1998). "TAL1 and LIM-only proteins synergistically induce retinaldehyde dehydrogenase...
31 KB (3,723 words) - 06:25, 25 July 2024
LMO2 has been shown to interact with: GATA1, GATA2, JARID1A, MLLT4, and TAL1 GRCh38: Ensembl release 89: ENSG00000135363 – Ensembl, May 2017 GRCm38: Ensembl...
16 KB (1,997 words) - 04:55, 8 April 2025
Yoneyama, Akiko; Yoshikawa, Kazuhiro; Ikeda, Hiroshi (2008-10-01). "SCL/TAL1 Interrupting Locus Derepresses GLI1 from the Negative Control of Suppressor-of-Fused...
16 KB (2,251 words) - 16:15, 31 March 2025
gene may be negatively regulated by T-cell acute lymphocytic leukemia 1 (TAL1). In humans, the IAN subfamily genes are located in a cluster at 7q36.1....
5 KB (587 words) - 09:03, 9 January 2024
threshold 2 homolog TACSTD2: tumor-associated calcium signal transducer 2 TAL1 (1p33) TCTEX1D4: encoding protein Tctex1 domain containing 4 TCEB3: Transcription...
47 KB (3,307 words) - 00:15, 1 June 2025
embryonic hematopoiesis by repressing the expression of the transcription factor Tal1. In this embryonic stage, NANOG represses Pou3f1, a transcription factor...
21 KB (2,462 words) - 12:48, 21 January 2024
Q01995 16261 TAGLN2 HGNC:11554 P37802 16262 TAGLN3 HGNC:29868 Q9UI15 16263 TAL1 HGNC:11556 P17542 16264 TAL2 HGNC:11557 Q16559 16265 TALDO1 HGNC:11559 P37837...
242 KB (17 words) - 18:43, 6 October 2024
promotes cell cycle progression. T-cell acute lymphocytic leukemia protein 1 (TAL1) is an oncogenic transcription factor in T-cell acute lymphoblastic leukemia...
20 KB (1,675 words) - 23:17, 23 May 2025
CREBBP, ELK3, EP300, ID3, LDB1, LMX1A, LYL1, MAPKAPK3, MyoD, Myogenin, PCAF, TAL1 TWIST1, and UBE2I. GRCh38: Ensembl release 89: ENSG00000071564 – Ensembl...
11 KB (1,186 words) - 05:47, 5 August 2024
T-box Known motif – High-throughput in vitro [892] ANGTGYGAHWWNTVRCACCT TAL1 ENSG00000162367 bHLH Known motif – In vivo/Misc source [893] RNCAGVTGGH TAL2...
374 KB (81 words) - 11:17, 3 January 2025
LDB1 has been shown to interact with other proteins such as LMO4, TCF3, TAL1 and CBFA2T3. GRCh38: Ensembl release 89: ENSG00000198728 – Ensembl, May 2017...
9 KB (1,074 words) - 19:29, 23 April 2024
PPARA, PPARG, RORA, RELA, SMAD1, SMAD2, SMAD7, SNIP1, SS18, STAT3, STAT6, TAL1, TCF3, TFAP2A, TGS1, TRERF1, TSG101, THRA, TWIST1, YY1, and Zif268. GRCh38:...
37 KB (4,193 words) - 15:18, 28 October 2024
TFIIF. Other proteins include CIITA, Brm (chromatin remodeler), NF-κB (p65), TAL1/SCL, Beta2/NeuroD, C/EBPβ, IRF2, IRF7, YY1, KLF13, EVI1, AME, ER81, and the...
53 KB (6,150 words) - 23:27, 22 May 2025
is caused when one or more genes encoding transcription factors including TAL1, TLX1, HOXA, TAL2, LYL1, LMO1, LMO2, or NKX3 are genetically fused to other...
13 KB (1,590 words) - 21:21, 1 March 2025
T-ALL (with Jon C. Aster) Discovery of somatic enhancer mutations activating TAL1 The first zebrafish model of cancer - MYC-induced T-ALL in the zebrafish...
13 KB (1,392 words) - 22:07, 28 November 2023
transcription factor. Embryos lacking Tal1 fail to develop past embryonic day 9.5. However, the study found that Tal1 is actually required for vascular remodeling...
26 KB (3,444 words) - 20:02, 18 May 2024
MSX1, Myogenin, POU2F1, PPP1R13L, PSMC5, PML, RELA, SMAD3, SUMO1, SF1, TAL1, UBC. WRN, DDX3X GRCh38: Ensembl release 89: ENSG00000185591 – Ensembl, May...
30 KB (3,441 words) - 08:44, 5 February 2025
1073/pnas.88.24.11416. PMC 53146. PMID 1763056. Baer R (December 1993). "TAL1, TAL2 and LYL1: a family of basic helix-loop-helix proteins implicated in...
4 KB (573 words) - 19:49, 13 October 2022
interactions with a network of hematopoietic transcription factors including RUNX1, TAL1, MYB, GFI1, FLI1, LYL1, and PU.1. It is not exactly clear how reduced levels...
22 KB (2,579 words) - 20:02, 19 March 2025
development), ZBTB16 (transcription factor regulating cell cycle progression), TAL1 (a transcription factor), FOG2 (a transcription factor regulator), and GATA2...
45 KB (5,512 words) - 16:07, 11 March 2025
cells), GATA2 interacts with other transcription factors (viz., RUNX1, SCL/TAL1, GFI1, GFI1b, MYB, IKZF1, Transcription factor PU.1, LYL1) and cellular receptors...
50 KB (5,784 words) - 01:18, 29 January 2025
has been shown to interact with: HDAC1, HDAC3, LDB1, PRKAR2A, RUNX1T1 and TAL1, and TCF3. GRCh38: Ensembl release 89: ENSG00000129993 – Ensembl, May 2017...
8 KB (1,059 words) - 06:06, 24 February 2025
cells), GATA2 interacts with other transcription factors (viz., RUNX1, SCL/TAL1, GFI1, GFI1b, MYB, IKZF1, Transcription factor PU.1, LYL1) and cellular receptors...
34 KB (4,038 words) - 10:22, 27 November 2024
have been found to be essential in this differentiation, such as RUNX1 and TAL1 (also known as SCL). ST-HSCs can then differentiate into either the common...
45 KB (5,516 words) - 22:43, 24 May 2025