DNA topoisomerase 2-beta is an enzyme that in humans is encoded by the TOP2B gene. This gene encodes a DNA topoisomerase, an enzyme that controls and...
19 KB (2,287 words) - 08:34, 10 May 2025
neurons are activated in vitro, just 22 of TOP2B-induced double-strand breaks occur in their genomes. Such TOP2B-induced double-strand breaks are accompanied...
138 KB (16,929 words) - 21:22, 10 May 2025
appear to depend on double-strand breaks initiated by topoisomerase 2β (TOP2B) for activation. The induction of particular double-strand breaks is specific...
36 KB (4,283 words) - 00:32, 16 May 2025
neurons are activated in vitro, just 22 of TOP2B-induced double-strand breaks occur in their genomes. Such TOP2B-induced double-strand breaks are accompanied...
52 KB (6,235 words) - 08:34, 10 May 2025
kinase inhibitors, Xist antisense oligonucleotides (ASOs), and DNA TOP2A/TOP2B knockdown. Some experimental synergistic combinations of drugs have outperformed...
41 KB (5,094 words) - 03:44, 4 May 2024
PDK1, PDK2, PDK3, PDK4 PMS1, PMS2, PMS2L1, PMS2L11, PMS2L3, PMS4L TOP2A, TOP2B TRAP1, TRRAP Prodromou C, Roe SM, Piper PW, Pearl LH (June 1997). "A molecular...
7 KB (437 words) - 15:16, 1 October 2024
SMN1, STAT3, TBP, TFAP2A, TFDP1, TIGAR, TOP1, TOP2A, TP53BP1, TP53BP2, TOP2B, TP53INP1, TSG101, UBE2A, UBE2I, UBC, USP7, USP10, WRN, WWOX, XPB, YBX1...
131 KB (14,361 words) - 00:12, 13 May 2025
the genes at which it occurs, the DNA double-stranded break induced by TOP2B is thought to be part of the process of regulation of gene expression. DNA...
57 KB (6,173 words) - 00:11, 11 December 2023
to correlate with cell proliferation - but β did not. Topoisomerase II TOP2B - Topoisomerase II beta Gene duplication Ataxia-telangiectasia TOPBP1 GRCh38:...
6 KB (660 words) - 06:10, 21 April 2025
reviewed in 2022. These mechanisms include, for instance, signal-responsive TOP2B-induced double-strand breaks in immediate early genes. More than 100 DNA...
61 KB (7,936 words) - 18:24, 19 April 2025
SMC1A No ACTBL2 ACTBL Yes SPTBN1 SPTB2 No DHX15 DHX15 No ARG1 ARGI1 No TOP2B TOP2B No APOBEC3F ABC3F No NOP58 NOP58 Yes RPF2 RPF2 No S100A9 S100A9 Yes DDX41...
28 KB (2,093 words) - 18:17, 31 October 2024
radicals that in turn damage cardiac myocytes. Recent research suggests that Top2b (topoisomerase-IIβ) helps mediate the production of oxygen radicals, representing...
31 KB (3,410 words) - 11:51, 24 January 2025
surface glycoprotein CD3 epsilon chain has been shown to interact with TOP2B, CD3EAP and NCK2. CD3 (immunology) Cluster of differentiation GRCh38: Ensembl...
13 KB (1,591 words) - 03:47, 1 January 2024
P11387 17200 TOP1MT HGNC:29787 Q969P6 17201 TOP2A HGNC:11989 P11388 17202 TOP2B HGNC:11990 Q02880 17203 TOP3A HGNC:11992 Q13472 17204 TOP3B HGNC:11993 O95985...
242 KB (17 words) - 18:43, 6 October 2024
Albadine, R., Gurel, B., ... Yegnasubramanian, S. (2010). Androgen-induced TOP2B-mediated double-strand breaks and prostate cancer gene rearrangements. Nature...
7 KB (922 words) - 22:01, 24 August 2024
topoisomerase II. She was a co-discoverer of DNA topoisomerase IIbeta (TOP2B). Her most-cited article, Caroline Austin, KL Marsh. "Eukaryotic DNA topoisomerase...
4 KB (278 words) - 09:35, 24 October 2024
SATB1, SIN3A, SIN3B, SPEN, SUDS3, SUV39H1, Sp1 transcription factor, TOP2A, TOP2B, and Zinc finger and BTB domain-containing protein 16. Histone deacetylase...
50 KB (5,394 words) - 06:58, 3 May 2025
DAXX, DNMT3B, P53, PIAS1, PML, SAE2, SP1, TDG, TNFRSF1A, TNFRSF6, TOP2A, TOP2B, and UBE2I, Heart failure is a process by which the heart’s pumping ability...
20 KB (2,334 words) - 23:14, 18 August 2023
SMARCA5, SNW1, SUV39H1, Sp1 transcription factor, Sp3 transcription factor, TOP2B, and YY1. Histone deacetylase GRCh38: Ensembl release 89: ENSG00000196591...
41 KB (4,590 words) - 04:20, 6 January 2025