• An upstream open reading frame (uORF) is an open reading frame (ORF) within the 5' untranslated region (5'UTR) of an mRNA. uORFs can regulate eukaryotic...
    4 KB (418 words) - 11:33, 25 May 2025
  • subsequent interaction with the ribosome in translation). Such an open reading frame (ORF) may contain a start codon (usually AUG in terms of RNA) and...
    17 KB (1,996 words) - 17:31, 1 April 2025
  • Thumbnail for SNRPN upstream reading frame protein
    SNRPN upstream reading frame protein is a protein that in humans is encoded by the SNURF gene. This gene encodes a highly basic protein localized to the...
    7 KB (935 words) - 17:31, 12 May 2024
  • Thumbnail for Riboswitch
    fungus) controls alternative splicing to conditionally produce an Upstream Open Reading Frame (uORF), thereby affecting the expression of downstream genes...
    41 KB (4,351 words) - 05:32, 24 June 2025
  • Tuija; Willis, Anne E. (2013). "A perspective on mammalian upstream open reading frame function". The International Journal of Biochemistry & Cell Biology...
    21 KB (2,439 words) - 03:53, 25 February 2025
  • Thumbnail for Major vault protein
    Ambrosch I, Elbling L, Micksche M, Berger W (April 2001). "A small upstream open reading frame causes inhibition of human major vault protein expression from...
    12 KB (1,419 words) - 03:43, 3 June 2025
  • Chromosome 4 open reading frame 50 is a protein that in humans is encoded by the C4orf50 gene. The protein localizes in the nucleus. C4orf50 has orthologs...
    7 KB (524 words) - 02:26, 9 February 2025
  • Thumbnail for Lataisia Jones
    characterizing the "Translational Effects and Coding Potential of an Upstream Open Reading Frame Associated with DOPA Responsive Dystonia (DRD)". Her research...
    15 KB (1,533 words) - 16:03, 25 March 2025
  • Thumbnail for Allregulin
    (hepatitis C virus F protein-transactivated protein 1). Chromosome 4 open reading frame 3 is a protein encoding gene that is located on chromosome 4 with...
    5 KB (552 words) - 13:57, 20 December 2024
  • Thumbnail for C7orf26
    c7orf26 (Chromosome 7, Open Reading Frame 26) is a gene in humans that encodes a protein known as c7orf26 (uncharacterized protein c7orf26). Based on properties...
    16 KB (1,542 words) - 02:00, 10 March 2024
  • Thumbnail for Gcn2
    scanning the mRNA from 5' have TC bound and translate the first upstream open reading frame (uORF). Under non-starving condition there is enough ternary...
    18 KB (2,068 words) - 20:51, 31 December 2024
  • Thumbnail for Chromosome 9 open reading frame 43
    Chromosome 9 open reading frame 43 is a protein that in humans is encoded by the C9orf43 gene. The gene is also known as MGC17358 and LOC257169. C9orf43...
    13 KB (1,128 words) - 02:24, 9 February 2025
  • Thumbnail for Micropeptide
    Micropeptide (category Wikipedia articles incorporating text from open access publications)
    genomic location. For example, the translated product of an upstream open reading frame (uORF) might be called a uORF-encoded peptide (uPEP). Micropeptides...
    31 KB (3,888 words) - 10:13, 5 December 2024
  • Thumbnail for DAP3
    mitochondrial ribosomal protein S29 (MRPS29) expression by a 5'-upstream open reading frame". Mitochondrion. 10 (3): 274–83. doi:10.1016/j.mito.2009.12.150...
    18 KB (2,078 words) - 10:03, 20 October 2022
  • Thumbnail for METTL26
    located on the short arm of chromosome 16 in humans, in the thirteenth open reading frame. There are five transcript variants of this gene, named 1, 2, 3, 4...
    14 KB (1,306 words) - 06:18, 21 January 2025
  • Uncharacterized protein Chromosome 16 Open Reading Frame 71 is a protein in humans, encoded by the C16orf71 gene. The gene is expressed in epithelial tissue...
    22 KB (1,795 words) - 02:31, 22 March 2024
  • Thumbnail for ATF4
    on upstream open reading frames located in the 5'UTR. The location of the second uORF, aptly named uORF2, overlaps with the ATF4 open-reading frame. During...
    15 KB (1,773 words) - 09:05, 5 February 2025
  • Chromosome 1 open reading frame 141, or C1orf141 is a protein which, in humans, is encoded by gene C1orf141. It is a precursor protein that becomes active...
    15 KB (1,153 words) - 01:48, 10 March 2024
  • Thumbnail for C5orf52
    Chromosome 5 open reading frame 52 (C5orf52) is a gene of unknown function. It encodes the protein A6NGY3. The C5orf52 gene is strongly predicted to be...
    9 KB (992 words) - 03:14, 19 December 2024
  • Thumbnail for TARP (gene)
    its protein product is similar to TRG@ proteins. The upstream ORF uses a different reading frame and encodes a novel protein. GRCh38: Ensembl release...
    5 KB (637 words) - 00:02, 4 March 2023
  • Thumbnail for SLC66A3
    and KCNF1. ROCK2 and C2orf50 are both located upstream of SLC66A3 whereas KCNF1 is located upstream. SLC66A3 has 14 different mRNAs, there are 12...
    9 KB (748 words) - 02:26, 9 February 2025
  • Thumbnail for C5orf49
    Chromosome 5 open reading frame forty-nine, also known as C5orf49, is a protein that in humans is encoded by the C5orf49 gene. Aliases for C5orf49 include...
    6 KB (660 words) - 21:45, 26 September 2023
  • BZLF1 (BamHI Z fragment leftward open reading frame 1), also known as Zta, EB1, is an immediate-early viral gene of the Epstein–Barr virus (EBV) of the...
    4 KB (518 words) - 18:30, 16 July 2024
  • Thumbnail for BCKDK
    alpha-ketoacid dehydrogenase kinase mRNA is dependent upon an upstream open reading frame in the 5'-untranslated region". The Journal of Biological Chemistry...
    13 KB (1,418 words) - 15:33, 30 April 2025
  • According to the initial report, it has a short open reading frame (ORF) that encodes a leader peptide upstream of the resistance gene. A 75-nucleotide-long...
    3 KB (392 words) - 13:19, 21 March 2021
  • total translation rate and Cln3 translation rate caused by an Upstream open reading frame; another suggests that the increase in Cln3 activity at the end...
    29 KB (3,384 words) - 23:41, 1 January 2025
  • Thumbnail for C4orf51
    Chromosome 4 open reading frame 51 (C4orf51) is a protein which in humans is encoded by the C4orf51 gene. The C4orf51 gene is located at 4q31.21 on the...
    15 KB (1,210 words) - 01:58, 10 March 2024
  • Thumbnail for UPF0602
    UPF0602 is a protein in humans that is encoded by the chromosome 4 open reading frame 47 (c4orf47) gene. The c4orf47 gene is positioned at 4q35.1 on the...
    12 KB (1,059 words) - 11:30, 24 March 2024
  • Thumbnail for SnpEff
    variant was classified The 5 kb upstream/downstream reading frame provides for a more thorough analysis of upstream/downstream regions (the 1kb in ANNOVAR...
    7 KB (890 words) - 18:24, 26 August 2024
  • Thumbnail for C9orf152
    Chromosome 9 open reading frame 152 is a protein that in humans is encoded by the C9orf152 gene. The exact function of the protein is not completely understood...
    9 KB (701 words) - 02:02, 10 March 2024