V(D)J recombination (variable–diversity–joining rearrangement) is the mechanism of somatic recombination that occurs only in developing lymphocytes during...

vaccine development. V(D)J recombination in organisms with an adaptive immune system is a type of site-specific genetic recombination that helps immune cells...

required for opening the hairpins that are formed on DNA ends during V(D)J recombination, a specific type of NHEJ, and may also participate in end trimming...

combination is called V(D)J recombination and discussed below. Somatic recombination of immunoglobulins, also known as V(D)J recombination, involves the generation...

cells. TdT adds N-nucleotides to the V, D, and J exons of the TCR and BCR genes during antibody gene recombination, enabling the phenomenon of junctional...

Eukaryotic supergroups. V(D)J recombination, although not a DNA TE, is remarkably similar to transposons. V(D)J recombination is the process by which...

VDJ genes) to create millions of permutations, in a process called V(D)J recombination. RAG-1 and RAG-2 are proteins at the ends of VDJ genes that separate...

Impact on the junctional repair steps of V(D)J recombination". Molecular Immunology. 120: 93–100. doi:10.1016/j.molimm.2020.01.018. PMC 7184946. PMID 32113132...

number of genes available to V(D)J recombination, gene conversion between pseudogenic V segments and the currently-active V segment occur with SMH, thereby...

repair 1C) gene. Artemis is a nuclear protein that is involved in V(D)J recombination and DNA repair. The protein has endonuclease activity on 5' and 3'...

process of V(D)J recombination, but possessing distinct constant domains in their heavy chains. Naïve mature B cells produce both IgM and IgD, which are...

mutations. Somatic recombination occurs physiologically in the assembly of the B cell receptor and T-cell receptor genes (V(D)J recombination), as well as in...

Nobel Prize for Physiology or Medicine in 1987 for his discovery of V(D)J recombination, the genetic mechanism which produces antibody diversity. Although...

the chromosome. NHEJ is also used to repair DSBs generated during V(D)J recombination when gene regions are rearranged to create the unique antigen binding...

with the RAG1 protein, RAG2 forms a V(D)J recombinase, a protein complex required for the process of V(D)J recombination during which the variable regions...

created. Second, V(D)J recombination randomly selects one variable (V), one diversity (D), and one joining (J) region for genetic recombination and discards...

repair, which rejoins double-strand breaks. It is also required for V(D)J recombination, a process that utilizes NHEJ to promote immune system diversity...

immunoglobulin genes of Reed–Sternberg cells have undergone both V(D)J recombination and somatic hypermutation, establishing an origin from a germinal...

Recombination signal sequences are conserved sequences of noncoding DNA that are recognized by the RAG1/RAG2 enzyme complex during V(D)J recombination...

with XLF mutations also have immunodeficiency due to a defect in V(D)J recombination, which uses NHEJ to generate diversity in the antibody repertoire...

joining of gene segments during the process of V(D)J recombination. This process of V(D)J recombination has vital roles for the vertebrate immune system...

encoded by this gene is involved in antibody and T-cell receptor V(D)J recombination. RAG-1 is involved in recognition of the DNA substrate, but stable...

(spleen and thymus) and uses V(D)J recombination to create antigen recognition sites, rather than using genetic recombination in the variable lymphocyte...

dancer. V(D)J recombination, a mechanism of genetic recombination Visual J Sharp, or Visual J#, a programming language Victory over Japan Day, V-J Day Vojska...

Krangel (December 1, 2015). "Beyond Hypothesis: Direct Evidence That V(D)J Recombination Is Regulated by the Accessibility of Chromatin Substrates". Journal...

Artemis complex is a protein complex that functions in V(D)J recombination, the somatic recombination process which generates diversity in T cell receptors...

chain is coded for by V (variable), J (joining) and C (constant) genes in this region. These genes undergo V(D)J recombination to generate a diverse repertoire...

in the periphery, they rearrange special segments of their DNA [V(D)J recombination process]. This process requires them to make DSBs, which are difficult...

protein kinase (DNA-PKcs aka PRKDC), which leads to faulty V(D)J recombination. V(D)J recombination is necessary for recognition of a diverse range of antigens...

the smartest guy I know”. He was instrumental in the discovery of V(D)J recombination, bacteriophage genetics as part of the phage group and co-discoverer...