A disintegrin and metalloprotease 17 (ADAM17), also called TACE (tumor necrosis factor-α-converting enzyme), is a 70-kDa enzyme that belongs to the ADAM...
21 KB (2,494 words) - 10:51, 5 November 2024
pressure in check. mACE2 is cleaved by the enzyme ADAM17 in a process regulated by substrate presentation. ADAM17 cleavage releases the extracellular domain...
45 KB (5,270 words) - 15:30, 25 May 2025
needed] the yield of agonists. Sheddase inhibitors active on ADAM10 and ADAM17 can potentiate anti-cancer therapy. It has been postulated that the activity...
4 KB (465 words) - 18:18, 24 September 2024
(metargidin)". Li Y, Brazzell J, Herrera A, Walcheck B (October 2006). "ADAM17 deficiency by mature neutrophils has differential effects on L-selectin...
11 KB (672 words) - 12:29, 3 April 2025
a short transmembrane domain, and a cytoplasmic tail. It is cleaved by ADAM17. The nature of the interactions between L-selectin and ligand depends on...
22 KB (2,808 words) - 05:54, 17 March 2025
regulation of growth factor availability and mediating cell-matrix interactions. ADAM17 and ADAM15 have recently been identified in endothelial cells (EC). ADAMTS...
50 KB (5,463 words) - 22:55, 27 May 2025
shown to interact with: CD117, CD29 CD46, CD49c, CD81, PTGFRN, TSPAN4. CD63 ADAM17 CD81 Tetraspanin Myogenesis Fertilisation GRCh38: Ensembl release 89: ENSG00000010278...
27 KB (3,142 words) - 07:34, 10 June 2024
CD163 function. sCD163 shedding occurs as a result of enzymatic cleavage by ADAM17. sCD163 is upregulated in a large range of inflammatory diseases including...
18 KB (2,140 words) - 05:39, 26 March 2025
catalyzing a reaction in a lipid raft but lacks a substrate for activity. (ADAM17), also called TACE, is sequestered into lipid rafts away from its substrate...
16 KB (1,881 words) - 04:10, 21 October 2024
further research. More specifically, aderbasib is an inhibitor of ADAM10 and ADAM17. "STATEMENT ON A NONPROPRIETARY NAME ADOPTED BY THE USAN COUNCIL" (PDF)...
4 KB (196 words) - 17:54, 6 March 2025
PMID 18398673. S2CID 13229645. Sternlicht MD, Sunnarborg SW (June 2008). "The ADAM17-amphiregulin-EGFR axis in mammary development and cancer". Journal of Mammary...
60 KB (6,879 words) - 01:06, 1 March 2025
PMID 18398673. S2CID 13229645. Sternlicht MD, Sunnarborg SW (2008). "The ADAM17-amphiregulin-EGFR axis in mammary development and cancer". J Mammary Gland...
59 KB (6,495 words) - 19:13, 23 May 2025
only the prodomain is required for APP processing. Other ADAM proteins, ADAM17 (also called TACE, tumor necrosis factor-α converting enzyme), ADAM9, and...
9 KB (950 words) - 09:57, 27 March 2024
HGNC:189 O75078 255 ADAM12 HGNC:190 O43184 256 ADAM15 HGNC:193 Q13444 257 ADAM17 HGNC:195 P78536 258 ADAM18 HGNC:196 Q9Y3Q7 259 ADAM19 HGNC:197 Q9H013 260...
277 KB (17 words) - 18:34, 6 October 2024
SARS-CoV-2 infection. The enzyme Adam17 has similar ACE2 cleavage activity as TMPRSS2, but by forming soluble ACE2, Adam17 may actually have the protective...
25 KB (2,644 words) - 17:17, 5 February 2025
expressed as a transmembrane protein, but a soluble form cleaved off by ADAM17 is active in inhibiting adipogenesis, the differentiation of pre-adipocytes...
11 KB (1,303 words) - 21:36, 23 December 2023
pathways, such as the Notch signaling pathway, through the upregulation of ADAM17. GRCh38: Ensembl release 89: ENSG00000105447 – Ensembl, May 2017 GRCm38:...
6 KB (669 words) - 13:48, 10 January 2025
implicated in the proteolytic cleavage of LRP1 such as ADAM10, ADAM12, ADAM17 and MT1-MMP. LRP1 is also continuously endocytosed from the membrane and...
32 KB (3,450 words) - 20:21, 5 December 2024
H, Gierer S, Liepold T, Jahn O, Pöhlmann S (January 2014). "TMPRSS2 and ADAM17 cleave ACE2 differentially and only proteolysis by TMPRSS2 augments entry...
54 KB (6,051 words) - 23:09, 27 May 2025
time. Part of the ectodomain of TREM2 can be processed by enzymes (ADAM10, ADAM17) and released as a soluble version, called soluble TREM2 (sTREM2). This...
39 KB (4,094 words) - 04:24, 10 March 2025
Rabie T, Strehl A, Ludwig A, Nieswandt B (2005). "Evidence for a role of ADAM17 (TACE) in the regulation of platelet glycoprotein V." J. Biol. Chem. 280...
8 KB (1,000 words) - 17:40, 3 December 2023
proteolytic processing of the amyloid precursor protein. ADAM10, along with ADAM17, cleaves the ectodomain of the triggering receptor expressed on myeloid...
22 KB (2,606 words) - 23:38, 29 January 2025
PJ, et al. (Oct 2001). "Tumor necrosis factor-alpha-converting enzyme (ADAM17) mediates the cleavage and shedding of fractalkine (CX3CL1)". Journal of...
12 KB (1,379 words) - 04:56, 19 May 2025
carbonic anhydrase IX is a metalloprotease-dependent process regulated by TACE/ADAM17". British Journal of Cancer. 93 (11): 1267–76. doi:10.1038/sj.bjc.6602861...
22 KB (2,759 words) - 13:10, 5 November 2024
cleavage of the AXL extracellular domain by the metalloproteinases ADAM10 and ADAM17 can downregulate this signalling activity. Signalling pathways activated...
20 KB (2,438 words) - 20:23, 23 February 2025
Interleukin-6 receptor can be cleaved from the cell membrane by the protease ADAM17 generating a soluble receptor. The soluble interleukin-6 receptor can still...
15 KB (1,691 words) - 18:04, 2 June 2024
mice, iRhoms are key trafficking chaperones required for the ER export of ADAM17/TACE and its maturation. iRhoms are thus required for the TNF-alpha and...
42 KB (4,629 words) - 01:58, 16 December 2023
Hattori C, Szabó B, et al. (2003). "Putative function of ADAM9, ADAM10, and ADAM17 as APP alpha-secretase". Biochem. Biophys. Res. Commun. 301 (1): 231–5....
10 KB (1,218 words) - 17:32, 8 October 2024
gene known to be involved in regulating response to low oxygen levels, ADAM17, is also found in human Tibetan highlanders. Over 81 million people live...
53 KB (5,608 words) - 22:42, 25 May 2025
Disintegrin and metalloproteinase domain-containing protein 17; encoded by ADAM17 gene CD156c Disintegrin and metalloproteinase domain-containing protein...
96 KB (492 words) - 06:06, 25 November 2024