leucine zipper 1 (APPL1), or DCC-interacting protein 13-alpha (DIP13alpha), is a protein that in humans is encoded by the APPL1 gene. APPL1 contains several...
10 KB (1,118 words) - 05:08, 19 July 2025
Very rare, responds to sulfonylurea treatment AAPL1-MODY MODY 14 616511 APPL1 Mutated anchor protein in the insulin signalling pathway. Newly discovered...
24 KB (2,496 words) - 06:56, 18 July 2025
HGNC:24009 Q6UXV4 885 APP HGNC:620 P05067 886 APPBP2 HGNC:622 Q92624 887 APPL1 HGNC:24035 Q9UKG1 888 APPL2 HGNC:18242 Q8NEU8 889 APRT HGNC:626 P07741 890...
277 KB (17 words) - 16:09, 5 July 2025
formed from the C-terminal helix and strands 5 and 6. APBA1; APBA2; APBA3; APPL1; EPS8; EPS8L1; EPS8L2; EPS8L3; TENC1; TNS; TNS1; TNS3; TNS4; DOK1; DOK2;...
5 KB (506 words) - 03:33, 14 December 2023
PMC 1235301. PMID 11431708. Nechamen CA, Thomas RM, Dias JA (Nov 2006). "APPL1, APPL2, Akt2 and FOXO1a Interact with FSHR in a Potential Signaling Complex"...
3 KB (415 words) - 21:24, 15 July 2025
AFAP, AFAP1, AFAP1L1, AFAP1L2, AKAP13, AKT1, AKT2, AKT3, ANLN, APBB1IP, APPL1, APPL2, ARHGAP10, ARHGAP12, ARHGAP15, ARHGAP21, ARHGAP22, ARHGAP23, ARHGAP24...
16 KB (1,624 words) - 09:34, 30 June 2025
An elevated level of βCTF then causes Rab5 overactivation. βCTF recruits APPL1 to rab5 endosomes, where it stabilizes active GTP-Rab5, leading to pathologically...
38 KB (4,396 words) - 07:02, 19 July 2025
patient mutations in the ASH-RhoGAP domains of OCRL affect targeting and APPL1 binding". Biochem. Biophys. Res. Commun. 369 (2): 493–9. doi:10.1016/j.bbrc...
8 KB (1,047 words) - 06:45, 19 July 2025
FARS2 appears to interact with RCBTB2, KRTAP10-9, CALCOCO2, KRT40, MID2, APPL1, IKZF3, KRT13, TADA2A, STX11, TRIM27, KRTAP10-5, KRTAP10-7, TFCP2, MKRN3...
11 KB (1,264 words) - 16:33, 17 July 2025
antigen as well as the neu oncogene. AKT2 has been shown to interact with: APPL1, SH3RF1 and TCL1A. GRCh38: Ensembl release 89: ENSG00000105221 – Ensembl...
13 KB (1,538 words) - 16:17, 16 July 2025
Wall, A.A.; Luo, L.; Condon, N.D.; Stow, J.L. (2016). "Distinct Roles for APPL1 and APPL2 in Regulating Toll-like Receptor 4 Signaling in Macrophages: APPL...
15 KB (1,601 words) - 05:29, 12 July 2025
tolerance. Deleted in Colorectal Cancer has been shown to interact with: APPL1, Androgen receptor, Caspase 3, MAZ, NTN1 and PTK2. DCC's biological role...
39 KB (5,119 words) - 07:20, 9 June 2025