Alternative splicing, alternative RNA splicing, or differential splicing, is an alternative splicing process during gene expression that allows a single...
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of RNA splicing occur in nature; the type of splicing depends on the structure of the spliced intron and the catalysts required for splicing to occur...
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However, such transcripts are also produced by splicing errors in a process called "noisy splicing," and are also potentially translated into protein...
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Primary transcript (section Alternative splicing)
expression. Alternative splicing can be affected by various factors, including mutations such as chromosomal translocation. In prokaryotes, splicing is done...
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Serine/arginine-rich splicing factor 1 (SRSF1) also known as alternative splicing factor 1 (ASF1), pre-mRNA-splicing factor SF2 (SF2) or ASF1/SF2 is a...
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abundance of alternative splicing, which occurs in most human genes, and the specificity in which splicing is carried out in vivo. Splicing is distinctly...
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SR protein (section Splicing)
and alternative pre-mRNA splicing, mRNA export, genome stabilization, nonsense-mediated decay, and translation. SR proteins alternatively splice pre-mRNA...
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RNA-Seq (section Alternative splicing)
multiple alternative splicing modes: exon skipping (most common splicing mode in humans and higher eukaryotes), mutually exclusive exons, alternative donor...
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structure plots of alternative splicing events from .bam, .gtf, and .vcf files. SpliceR An R package for classification of alternative splicing and prediction...
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RBM10 (section Paralogs and splicing network)
chromosome at Xp11.23 in humans. RBM10 is a regulator of alternative splicing. Alternative splicing is a process associated with gene expression to produce...
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RNA-binding protein (section Alternative splicing)
exclusion during splicing. These sites are referred to as exonic splicing enhancers (ESEs), exonic splicing silencers (ESSs), intronic splicing enhancers (ISEs)...
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due to a variation in a single nucleotide (840.C→T) – undergoes alternative splicing at the junction of intron 6 to exon 8, with only 10–20% of SMN2 transcripts...
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Circular RNA (section Alternative splicing)
examples of alternative splicing is in the Drosophila DSCAM gene, which can give rise to approximately 30 thousand distinct alternatively spliced isoforms...
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is an Argentine molecular biologist who specializes in alternative ribonucleic acid splicing. During his postdoctoral training with Francisco Baralle...
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Baltimore classification (section Alternative splicing)
mRNA. Alternative splicing is a mechanism by which different proteins can be produced from a single gene by means of using alternative splicing sites...
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The primary function is regulation of alternative splicing of associated genes. Several alternatively spliced transcript variants have been found for...
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Intron (category RNA splicing)
relevant, alternative splicing and processing noise due to splicing errors. One of the central issues in the field of alternative splicing is working out the...
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of splicing factors. In D. melanogaster, Sxl exerts its effects primarily through post-transcriptional regulation, specifically alternative splicing and...
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still remains an important challenge. As a consequence, the role of alternative splicing in molecular biology remains largely elusive. Third generation sequencing...
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at the University of Montpellier, specializing in RNA metabolism, alternative splicing, and RNA-based therapeutic strategies. Tazi obtained a Ph.D. in molecular...
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Evolutionary tinkering (section Alternative splicing)
to a sequence could impact splicing, this process may result in changing the identity of introns and exons; alternatively, the sequence may retain its...
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RNA-based evolution (section Alternative splicing)
translation of messenger RNA. Splicing is the process by which non-coding regions of RNA are removed. The number and combination of splicing events varies greatly...
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alternative splicing compared to genes that code a single isoform. This is because alternatively spliced mRNAs are enriched in METTL3 binding sites. Splicing is...
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Mature messenger RNA (section RNA Splicing)
which cleaves the RNA at the splicing site and recombines the exons of the RNA. Similar to polyadenylation, alternative splicing can occur, resulting in several...
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Alternative Splicing Annotation Project (ASAP) in computational biology was a database for alternative splicing data maintained by the University of California...
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TNNT3 (section Alternative splicing)
alternative splicing of multiple exons to generate fsTnT variants, two-dimensional gel electrophoresis detected more than 40 different fsTnT splice forms...
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Exitron (category RNA splicing)
Exitrons (exonic introns) are produced through alternative splicing and have characteristics of both introns and exons, but are described as retained introns...
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Cav1.3 (section Alternative splicing)
pacemaking. Post-transcriptional alternative splicing of Cav1.3 is an extensive and vital regulatory mechanism. Alternative splicing can significantly affect...
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diverse with amplifications of Cδ exons. Different splice variants exist due to alternative splicing. In humans and primates, IgD has three Cδ domains...
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MAFA (section Alternative splicing)
transcribed into mRNA, the MAFA strand was also found to undergo alternative splicing which has allowed various forms of the MAFA protein to be translated...
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