Bi-specific T-cell engager (BiTE) is a class of artificial bispecific monoclonal antibodies that are investigated for use as anti-cancer drugs. They direct...

a Bi-specific T-cell engager (BiTE) used for the treatment of diffuse large B-cell lymphoma. Epcoritamab is a bispecific CD20-directed CD3 T-cell engager...

antibodies, bi-specific T-cell engagers (BiTEs), that exert action selectively and direct the human immune system to act against tumor cells. Blinatumomab...

used for the treatment of extensive-stage small cell lung cancer. It is a bispecific T-cell engager that binds delta-like ligand 3 and CD3. The most...

Imdelltra (tarlatamab-dlle), the first and only T-cell engager therapy for the treatment of extensive-stage small cell lung cancer" (Press release). Amgen. 16...

bispecific monoclonal antibody: 3funct: trifunctional antibody BiTE: bi-specific T-cell engager This list of over 500 monoclonal antibodies includes approved...

against cancer (ImmTAC molecules). Tebentafusp is a soluble, bi-specific t cell engager. On 23 November 2020, Immunocore announced a Phase 3 data readout...

bispecific GPRC5D-directed CD3 T-cell engager. Talquetamab is a bispecific antibody against two targets: human CD3, a T-cell surface antigen, and human G-protein...

multiple myeloma. Elranatamab is a bispecific B-cell maturation antigen (BCMA)-directed CD3 T-cell engager. Elranatamab is given by subcutaneous injection...

and pain. Teclistamab is the first bispecific B-cell maturation antigen (BCMA)-directed CD3 T-cell engager. Teclistamab was approved for medical use in the...

professional wrestling event produced by WWE BiTE, an acronym for bi-specific T-cell engagers, a class of specific modified antibodies BITE Model (Behavior...

lupus. Iberdomide has been tested in combination with Bi-specific T-cell engagers in the B-Cell Non-Hodgkin Lymphoma setting, but has been dropped in...

antibodies. The furthest developed of these newer formats are the bi-specific T-cell engagers (BiTEs), which uses the G4S linker to connect two ScFvs-one CD3...

CRISPR-Cas9 to develop the CAR-T cells that incorporate a molecule called Bi-specific T-cell engager (BiTE). Bi-specific T cell engager continues to produce short-lived...

bispecific monoclonal antibody currently being trialed for use against non-small-cell lung cancer. Developed by Akeso Biopharma, it has been approved in China...

that is used for the treatment of follicular lymphoma or diffuse large B-cell lymphoma. It was developed by Regeneron Pharmaceuticals. The most common...

but the concept was dropped because of high production costs. Bi-specific T-cell engagers employ a similar mechanism of action while being cheaper. Karpovsky...

developed of these are bispecific tandem di-scFvs, known as bi-specific T-cell engagers (BiTE antibody constructs). Pexelizumab, a scFv binding to component...

treatment of follicular lymphoma. It bispecifically binds CD20 and CD3 to engage T-cells. It was developed by Genentech. The most common adverse reactions (≥20%)...

tumor cells. Helwick C (June 2008). "Novel BiTE antibody mediates contact between T cells and cancer cells". Oncology NEWS International. 17 (6). Clinical...

activity through T cell redirection, a mechanism of action used by several other bi-specific biologics such as the Bi-specific T-cell engagers (BiTEs). After...

purchase the rights to Boehringer Ingelheims Phase I bispecific T-cell engager compound (BI 836909, now AMG 420) for use in the treatment of multiple myeloma...

binding domain of SIRPα, allowing it to simultaneously engage both CD20 and CD47 on cancer cells. Amulirafusp alfa has a dual mechanism of action that...

structures, of which bi-specific T-cell engagers (BiTEs) have been produced since the mid-2000s. At first, mouse hybridoma cells whose monoclonal antibodies...

differentiated), and rely on survival niches comprising specific cell types and cytokines to persist. Plasma cells will secrete huge quantities of antibody regardless...

DNA vaccine is a type of vaccine that transfects a specific antigen-coding DNA sequence into the cells of an organism as a mechanism to induce an immune...

determining cell fate. Past research shows that SKs may sustain cancer cell growth because they promote cellular-proliferation, and SK1 (a specific type of...

is not found in red blood cells, or spermatozoa. There are two types of ER that share many of the same proteins and engage in certain common activities...

2020). "Cell differentiation: What have we learned in 50 years?". Journal of Theoretical Biology. 485: 110031. arXiv:1907.09551. Bibcode:2020JThBi.48510031N...

Patrick A.; Kufer, Peter; Bargou, Ralf (February 2009). "BiTE: Teaching antibodies to engage T-cells for cancer therapy". Current Opinion in Molecular Therapeutics...