Cellular senescence is a phenomenon characterized by the cessation of cell division. In their experiments during the early 1960s, Leonard Hayflick and...

proteostasis, deregulated nutrient sensing, mitochondrial dysfunction, cellular senescence, stem cell exhaustion, altered intercellular communication In a decadal...

instability can lead to cellular senescence, and thus to SASP The high-mobility group proteins (HMGA) can induce senescence and SASP in a p53-dependent...

would have been subject to the 50 ± 10 mitosis event limit until cellular senescence occurs as described in Hayflick's findings. Hayflick first became...

protects against cancer while increasing the risks associated with cellular senescence. p16 is an inhibitor of cyclin-dependent kinases (CDK). It slows...

important and harmful role in autoimmunity, obesity, depression, and cellular senescence. The toxic activity of LPS was first discovered and termed endotoxin...

Much of Campisi's work focuses on the complex relationship between cellular senescence, aging and cancer. Her research is leading to new discoveries in...

three major types of cellular senescence, namely replicative senescence, oncogene-induced senescence and DNA damage-induced senescence are descriptions of...

Altemus, Margaret (1999). "Biochemical Aspects of Anxiety". Basic Neurochemistry: Molecular, Cellular and Medical Aspects. 6th edition. Lippincott-Raven....

patients with this disease. CPEB has been found to help regulate cellular senescence through modulating p53 mRNA polyadenylation-induced translation....

mitochondrial dysfunction, cellular senescence, stem cell exhaustion, and altered intercellular communication." Oxidation damage to cellular contents caused by...

differentiation and a more permanent growth arrest associated with cellular senescence. The p21 gene contains several p53 response elements that mediate...

This timeline lists notable events in the history of research into senescence or biological aging, including the research and development of life extension...

in the process of cellular senescence, which is related to, and yet distinct from, organismal aging. Replicative cellular senescence refers to a permanent...

be reversible or irreversible. Depending on the extent of injury, the cellular response may be adaptive and where possible, homeostasis is restored. Cell...

1194/jlr.M039446. PMC 3735945. PMID 23840049. Moiseeva V, et al. (2022). "Senescence atlas reveals an aged-like inflamed niche that blunts muscle regeneration"...

in response, trigger expression of inflammatory genes that can lead to senescence or to the activation of defense mechanisms. DNA is normally found in the...

monosaccharides. Senescence-associated beta-galactosidase, along with p16Ink4A, is regarded to be a biomarker of cellular senescence. Its existence was...

can occur as a result of either programmed cell death (apoptosis), cellular senescence, or necrosis. [citation needed] In apoptosis, the cleavage of DNA...

Programmed cell death (PCD) sometimes referred to as cell, or cellular suicide is the death of a cell as a result of events inside of a cell, such as apoptosis...

animal tissues alive in culture. He was interested in the phenomenon of senescence or aging. He believed that all cells continued to grow indefinitely, which...

cells. Cellular senescence occurs in response to DNA damage and external stress and usually constitutes an arrest in G1. Cellular senescence may make...

proliferate indefinitely but, due to mutation, have evaded normal cellular senescence and instead can keep undergoing division. The cells can therefore...

associated with hepatic dysfunction. Cirrhosis CYR61 induction of cellular senescence in the kidney has shown potential to limit renal fibrosis. Glial...

characteristics. The word senescence can either refer to cellular senescence or to senescence of a whole organism. Negligible senescence is therefore defined...

no longer replicate, they remain able to perform many normal cellular functions. Senescence is often a biochemical alternative to the self-destruction of...

to damage) Deregulated nutrient sensing Mitochondrial dysfunction Cellular senescence Integrative hallmarks (culprits of the phenotype) Stem cell exhaustion...

to treat patients with coronavirus. Mitochondrial ROS can promote cellular senescence and aging phenotypes in the skin of mice. Ordinarily mitochondrial...

Venetoclax YPEL3 § Cellular senescence Childs BG, Durik M, Baker DJ, van Deursen JM (December 2015). "Cellular senescence in aging and age-related disease:...

been shown to induce cellular senescence. Conversely, overexpression of SIRT1 in HUVECs has been shown to inhibit cellular senescence. The polyphenol quercetin...