Clinical endpoints or clinical outcomes are outcome measures referring to occurrence of disease, symptom, sign or laboratory abnormality constituting a...

In clinical trials, a surrogate endpoint (or surrogate marker) is a measure of effect of a specific treatment that may correlate with a real clinical endpoint...

Outcome measure, a measure used as an endpoint in research Clinical endpoint, in clinical research, a disease, symptom, or sign that constitutes one of...

announced in April 2022 that tirzepatide had successfully met its clinical endpoints in obese and overweight participants without diabetes. In industry-funded...

static condition. Progressive disease can also be a clinical endpoint i.e. an endpoint in a clinical trial. A progressive disease should not be confused...

Clinical study design is the formulation of clinical trials and other experiments, as well as observational studies, in medical research involving human...

oscillations are emerging as secondary endpoints in clinical trials and in quantifying effects in pre-clinical studies. These biomarkers are often named...

solely on clinical endpoints are very costly as they have long durations and tend to need large numbers of patients. In contrast to clinical endpoints, surrogate...

types of survival rates (discussed below). They often serve as endpoints of clinical trials and should not be confused with mortality rates, a population...

misusing statistics to exaggerate treatment benefits Setting a dubious clinical endpoint in research Advertising a treatment as without side effect Advertising...

treatment. Many drugs may be abandoned due to their failure to meet a clinical endpoint. Over time, manufacturers wanting to re-investigate the abandoned...

early clinical development and typically refers to an evaluation of the effect of a new treatment on disease biomarkers, but not the clinical endpoints of...

Kleiman, Evan M. (2020). "Suicidal thinking as a valuable clinical endpoint". eClinicalMedicine. 23: 100399. doi:10.1016/j.eclinm.2020.100399. ISSN 2589-5370...

outcome measure, endpoint, effect measure or measure of effect is a measure within medical practice or research, (primarily clinical trials) which is...

effectiveness and regulatory approval is controversial. It is often used as a clinical endpoint in randomized controlled trials for cancer therapies. It is a metric...

used. The NNT is an important measure in pharmacoeconomics. If a clinical endpoint is devastating enough (e.g. death, heart attack), drugs with a high...

nephropathy in 2014. However, the trial did not reach the primary clinical endpoint of reduction in albuminuria. Following this, the company conducted...

trial is a type of prospective, disease-focused, adaptive, randomized clinical trial (RCT) that compares multiple, simultaneous and possibly differently-timed...

bakers, a sound evidence base for measurable effects on health related clinical endpoints has not been established". Food portal List of sourdough breads Biga...

interpret a clinical trial endpoint. This is in contrast to traditional single-arm (i.e. non-randomized) clinical trials or randomized clinical trials (RCTs)...

endpoint time ratio, which likely would have been close to unity, i.e. mortality was largely the same regardless of group membership and clinically insignificant...

primary clinical endpoint data is August 2019. As of October 2020, there are multiple therapeutic HPV vaccines in active development and in clinical trials...

expose the patient to harms while providing therapeutic benefits. If a clinical endpoint is devastating enough without the drug (e.g. death, heart attack)...

planned clinical endpoint, but the trial has been criticized as being underpowered, limiting endovascular options, and comparing inappropriate endpoints. As...

design Block design Box–Behnken design Central composite design Clinical trial Clinical study design Computer experiment Control variable Controlling for...

These are broadly categorized as clinical endpoints, surrogate endpoints, and biological mediators. Clinical endpoints are variables which affect how people...

determining the initial dose regimen to be given to a patient, based on clinical endpoint and on established population pharmacokinetic-pharmacodynamic (PK/PD)...

understanding of the trial drug characteristics, or when specific clinical endpoints were measured rather than using surrogate outcomes. Umscheid, Craig...

communicator, is a person who applies the principles of clinical research in developing clinical trial documents that effectively and clearly describe research...

the monetary gold standard. "Gold standard" can refer to popular clinical endpoints by which scientific evidence is evaluated. For example, in resuscitation...