A coactivator is a type of transcriptional coregulator that binds to an activator (a transcription factor) to increase the rate of transcription of a...

to the lac promoter. CRISPR activation Bacterial transcription Coactivator (genetics) Eukaryotic transcription Glossary of gene expression terms Operon...

structure remodeling complex ISWI protein SMARCA1, SMARCA2 Coactivator (genetics) Corepressor (genetics) Nuclear receptor coregulators RNA polymerase control...

polymerase and other transcription machinery in the same region. See also coactivator; contrast repressor. active site The region of an enzyme to which one...

1038/nrg2322. PMID 18319743. S2CID 690431. Shoag J; et al. (Jan 2013). "PGC-1 coactivators regulate MITF and the tanning response". Mol Cell. 49 (1): 145–157. doi:10...

Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α) is a protein that in humans is encoded by the PPARGC1A gene. PPARGC1A is...

In genetics, a promoter is a sequence of DNA to which proteins bind to initiate transcription of a single RNA transcript from the DNA downstream of the...

In genetics, an enhancer is a short (50–1500 bp) region of DNA that can be bound by proteins (activators) to increase the likelihood that transcription...

The p300-CBP coactivator family in humans is composed of two closely related transcriptional co-activating proteins (or coactivators): p300 (also called...

agonist) AF-2 binds either the N-terminal FXXFL motif intramolecularly or coactivator proteins (containing the LXXLL or preferably FXXFL motifs) A ligand dependent...

Both of these related proteins, prototypical members of the p300-CBP coactivator family, have a bromodomain and a histone acetyltransferase domain and...

transcriptional coregulator, is essential for cell function because as a coactivator at a significant number of promoters, it activates the transcription...

Mediator is a multiprotein complex that functions as a transcriptional coactivator. The Mediator complex is required for the successful transcription of...

different proteins such as transcriptional coactivator or corepressors. Furthermore, the ratio of coactivator to corepressor protein varies in different...

Rosenfeld MG (April 1999). "Coactivator and corepressor complexes in nuclear receptor function". Current Opinion in Genetics & Development. 9 (2): 140–7...

domain. Cleavage by kallikrein also helps HMWK to optimally function as a coactivator. The cleavage results in a change in the conformation of HMWK that may...

that exhibit HAT activity. These include p300/CBP, nuclear receptor coactivators (e.g., ACTR/SRC-1), TAFII250, TFIIIC, Rtt109, and CLOCK. p300/CBP are...

ligand-binding domain (see below) induced by ligand binding and by a number of coactivator and corepressor proteins, the presence of which can stimulate or inhibit...

underscored the crucial role of coactivators in a wide range of physiological processes and diseases, including genetics, reproduction, metabolism, inflammation...

interaction of nuclear receptors with the putative human transcriptional coactivator hTIF1". The Journal of Biological Chemistry. 272 (18): 12062–8. doi:10...

intermittent hyperventilation (Pitt-Hopkins syndrome)". American Journal of Human Genetics. 80 (5): 994–1001. doi:10.1086/515583. PMC 1852727. PMID 17436255. Watkins...

to the dimerization interface of the receptor and in addition, binds coactivator and corepressor proteins. The LBD also contains the activation function...

is an ongoing area of research. KMT2A gene encodes a transcriptional coactivator that plays an essential role in regulating gene expression during early...

Coactivator: CREBBP Rubinstein–Taybi syndrome Corepressor: HR (Atrichia with papular lesions)...

Staphylococcal nuclease domain-containing protein 1 also known as 100 kDa coactivator or Tudor domain-containing protein 11 (TDRD11) is a protein that in humans...

the zebrafish restores normal development. MED12 is also a critical coactivator for the gene SOX9, which is involved in the developmental regulation...

corepressors and in the presence of coactivators, transcription factors upregulate gene expression. Coactivators and corepressors compete for the same...

Krüppel-type zinc finger (ZNF) MADS-box gene family NOTCH2NL P300-CBP coactivator family SOX gene family Immunoglobulin superfamily Major histocompatibility...

and silencers. The LCR functions by recruiting chromatin-modifying, coactivator, and transcription complexes. Its sequence is conserved in many vertebrates...

known as activators and repressors, and, in some cases, associated coactivators or corepressors, which modulate formation and function of the transcription...