A DNA clamp, also known as a sliding clamp, is a protein complex that serves as a processivity-promoting factor in DNA replication. As a critical component...

increase is facilitated by the DNA polymerase's association with proteins known as the sliding DNA clamp. The clamps are multiple protein subunits associated...

Look up clamp or clamps in Wiktionary, the free dictionary. Clamp may refer to: Brick clamp, an early method of baking bricks Clamp (tool), a device or...

primer-template junctions interact with the clamp loader, which loads the sliding clamp onto the DNA to begin DNA synthesis. The components of the preinitiation...

the DNA polymerases performing the replication. DNA clamp proteins are integral components of the DNA replication machinery and serve to increase the...

subunit's proofreading. 2 β units (dnaN) which act as sliding DNA clamps, they keep the polymerase bound to the DNA. 2 τ units (dnaX) which act to dimerize two...

organisms, DNA polymerases function in a large complex called the replisome that contains multiple accessory subunits, such as the DNA clamp or helicases...

touch) the DNA. Clamp domain, which is inserted between the two subdomains of the core domain at the top of the lever helices; the clamp domain has a...

A Ramachandran plot generated from human PCNA, a trimeric DNA clamp protein that contains both β-sheet and α-helix (PDB ID 1AXC). The red, brown, and...

dnaN is the gene that codes for the DNA clamp (also known as β sliding clamp) of DNA polymerase III in prokaryotes. The β clamp physically locks Pol III...

(PDB 1AXC), a sliding DNA clamp protein that is part of the DNA replication complex and serves as a processivity factor for DNA polymerase. The three...

(primase or DNA polymerase alpha) Ensuring processivity (clamp loading factors, ring-shaped clamp proteins, strand binding proteins) High-fidelity DNA replication...

Proliferating cell nuclear antigen (PCNA) is a DNA clamp that acts as a processivity factor for DNA polymerase δ in eukaryotic cells and is essential for...

DNA polymerase epsilon is a member of the DNA polymerase family of enzymes found in eukaryotes. It is composed of the following four subunits: POLE (central...

material between generations requires timely and accurate duplication of DNA by semiconservative replication prior to cell division to ensure each daughter...

is the T7 DNA polymerase. T7 DNA polymerase uses E. coli's endogenous thioredoxin, a REDOX protein, as a sliding DNA clamp during phage DNA replication...

replicator is the entire DNA sequence (including, but not limited to the origin of replication) required to direct the initiation of DNA replication. The initiator...

all coronavirus variants of concern. ZyCoV-D vaccine – The world's first DNA-based vaccine for humans. Carbon nitride solar reactor – In September 2021...

thermostable DNA polymerases (Q5 polymerase) were generated from various thermostable polymerases and the DNA clamp of the thermostable DNA-binding protein...

of DNA replication stress. The RAD9-HUS1-Rad1 (9-1-1) heterotrimeric clamp and its clamp loader RFCRad17 are able to recognize gapped or nicked DNA. The...

through its role as the clamp loader for PCNA (which involves catalysing the loading of PCNA on to DNA) is important for DNA Pol δ function.[citation...

pairs with the homopurine DNA strand in the DNA-PNA duplex. A tail clamp PNA (tcPNA) is also another form of triplex clamp that can also be formed. TcPNAs...

N-terminal domain, approx. 365 amino acids. The eukaryotic equivalent to the DNA clamp loader is replication factor C, with the subunits RFC1, RFC2, RFC3, RFC4...

protein that encircles DNA for function referred to as a DNA-sliding clamp. The DNA clamp tethers the DNA polymerase to its DNA template thereby allowing...

DNA polymerase epsilon catalytic subunit is an enzyme that in humans is encoded by the POLE gene. It is the central catalytic subunit of DNA polymerase...

polymerases, DNA polymerase α-primase and DNA polymerase δ. This process starts with polymerase α-primase displacing from the RNA and DNA primer by the clamp loader...

is a five subunit DNA polymerase accessory protein. Replication factor C is a DNA-dependent ATPase that is required for eukaryotic DNA replication and repair...

that nicks are sites for RFC-dependent loading of the replication sliding clamp, proliferating cell nuclear antigen (PCNA), in an orientation-specific manner...

as DNA damage or an active replication fork. In bacteria, the Mfd ATPase can remove a RNA polymerase stalled at a lesion by prying open its clamp. It...

similar to proteins involved in forming the clamp that increases the processivity of DNA polymerase during DNA replication. In agreement with this idea,...