generation of bisphosphonates included etidronic acid and clodronic acid which were introduced in the 1970s and 1980s. They were the first bisphosphonate drugs...

of the jaw (MRONJ), has been described as a side-effect of amino-bisphosphonates, a class of phosphorus-based drugs that inhibit bone resorption and are...

intravenous bisphosphonates, with most cases being reported in cancer patients. Bone: alendronate has been linked in long-term users to the development of low-impact...

supports the use of medications of the bisphosphonate class, such as pamidronate, to increase bone density. Bisphosphonates are especially effective in children;...

Fry, C.; Thoennessen, M. (2013). "Discovery of the astatine, radon, francium, and radium isotopes". Atomic Data and Nuclear Data Tables. 09 (5): 497–519...

The Development of a New Proton-Pump Inhibitor: The Case History of Pantoprazole". In Fischer J, Ganellin CR (eds.). Analogue-based drug discovery. Weinheim:...

fibrosis, the evidence about the effectiveness of antibiotics for S. maltophilia is uncertain. Bisphosphonates taken by mouth or intravenously can be used...

infection, Gaucher's disease, and Caisson disease (dysbaric osteonecrosis). Bisphosphonates are associated with osteonecrosis of the mandible (jawbone). The...

Transactions of the Royal Society. 98: 1–44. doi:10.1098/rstl.1808.0001. Shaposhnik VA (2007). "History of the discovery of potassium and sodium (on the...

is a bisphosphonate. It slows down the cells which break down bone. It's used to treat or prevent osteoporosis, and treat Paget's disease of bone. It...

identified as a key mediator of the effects of statins and bisphosphonates on bone, muscle, and macrophages. On the basis of these findings, it has been...

denosumab and the bisphosphonates; infusion every three months reduces the chance of bone pain, fractures, and bone hypercalcemia. Up to 70% of those with ER-positive...

other bisphosphonates as first line treatments for post-menopausal osteopotosis. Long-term treatment with bisphosponates produces anti-fracture and bone...

As of 2013, high-quality evidence supports the use of bisphosphonates (either orally or via IV infusion) in the treatment of CRPS. Bisphosphonates inhibit...

effects of use of bisphosphonates which can cause osteochemonecrosis of the bone. The chance of further bleeding reduces as healing progresses, and is unlikely...

may vitamin D. When medication is used, it may include bisphosphonates, strontium ranelate, and osteoporosis may be one factor considered when commencing...

reduction of bone pain or improvements in quality of life. Bone-targeted agents (BTAs) including bisphosphonates and denosumab, can interrupt osteoclast-mediated...

of calcium, vitamin D, and bisphosphonates. Inadequate amounts of calcium, vitamin D, or phosphates can lead to softening of bones, called osteomalacia...

"Preventing Bone Loss in Space Flight with Prophylactic Use of Bisphosphonate: Health Promotion of the Elderly by Space Medicine Technologies". 27 May 2015...

People with thalassemia are at a higher risk of osteoporosis. Treatment options include bisphosphonates and zinc supplementation. The spleen is the organ...

of use, the cell became known by its present name. Giant osteoclasts can occur in some diseases, including Paget's disease of bone and bisphosphonate...

prevent and treat osteoporosis in postmenopausal women and those on glucocorticoids. For osteoporosis it is less preferred than bisphosphonates. It is...

removal and is active in the body for only six months. Similarly to bisphosphonates, denosumab appears to be implicated in increasing the risk of osteonecrosis...

therapy with bisphosphonates (a class of osteoporosis drugs) to treat problems with bone resorption associated with the bone breakdown and skeletal malformations...

autoimmunity by molecular mimicry and increase the chances of Sjögren's disease development. Epstein–Barr virus, hepatitis C, and human T-cell leukemia virus-1...

survival rates. Use of bisphosphonates appears to significantly increase survival. Etidronate, a non-nitrogen-containing bisphosphonate, is the most commonly...

followed by the discovery of point mutations. Over 30 genes have been associated with Crohn's; a biological function is known for most of them. For example...

effect of bisphosphonates on BMD did not provide significant evidence of improvement, and the scope of studies are inadequate to ensure safety and efficacy...

osteoclasts (like a bisphosphonate). PPIs have been associated with an increased risk for pneumonia by meta-analyses of case-control and cohort studies. One...

nitrogenous bisphosphonates such as alendronate, ibandronate, pamidronate, risedronate, and zoledronate, which are used in the treatment of osteoporosis...