Genetic load is the difference between the fitness of an average genotype in a population and the fitness of some reference genotype, which may be either...

w_{\max }}} Genetic load may increase when deleterious mutations, migration, inbreeding, or outcrossing lower mean fitness. Genetic load may also increase...

inbred populations, especially small ones, genetic drift causes alleles to become fixed in a population. Drift load is the decline in fitness in a population...

deleterious then the human species could not survive such a mutation load (genetic load). This led to predictions in the late 1940s by one of the founders...

Genetic load Genetic map Genetic marker Genetic material Genetic mosaic Genetic polymorphism Genetic screen Genetic screening Genetic testing Genetic...

Drift load, a type of genetic load, is the decline in fitness in a population due to the fixation of deleterious mutations by genetic drift. Drift load generally...

mutations remain in the population longer. H. J. Muller dubbed this "genetic load". Muller, motivated by his concern about the effects of radiation on...

that are closely related genetically. By analogy, the term is used in human reproduction, but more commonly refers to the genetic disorders and other consequences...

pulmonary arteries Genetic load, of a population Late-onset Alzheimer's disease (acronym: LOAD), a chronic neurodegenerative disease Parasite load, of an organism...

results in an eventual accumulation of mutations known as genetic load. In theory, the genetic load carried by asexual populations eventually becomes so great...

These types of malformations are caused by inbreeding depression or genetic load. Island populations often also have small populations due to geographic...

inbreeding load. This means that, after purging, further inbreeding is expected to be less harmful. The efficiency of purging is reduced by genetic drift and...

dynamics in a bacterial population reflect tension between adaptation and genetic load". Proceedings of the National Academy of Sciences of the United States...

Genetic rescue is seen as a mitigation strategy designed to restore genetic diversity and reduce extinction risks in small, isolated and frequently inbred...

of understanding whether low neutral genetic diversity is correlated with high genetic drift and high mutation load. In a review of current research, Teixeira...

en. Kuang, W.; Hu, J.; et al. (December 2020). "Genetic diversity, inbreeding level, and genetic load in endangered snub-nosed monkeys (Rhinopithecus)"...

the next generation because the offspring are exact genetic clones of their parents. The genetic load of organisms and their populations will increase due...

survivability. This could be caused by changes in trait distribution from genetic loading, exogenous environmental changes in the fitness landscape, or feedback...

the spores enter the airstream for long-distance dispersal, and a low genetic load allows spores that have grown into a gametophyte to self-fertilize with...

automatically be expressed, exposing them to natural selection. Thus, the genetic load of deleterious genes is purged relatively quickly. Some hymenopterans...

accumulation of deleterious mutations due to fixation by genetic drift. This loss of fitness is drift load, and it is a target of conservation genetics. A population...

Smeds L, Ellegren H (April 2023). "From high masked to high realized genetic load in inbred Scandinavian wolves". Mol Ecol. 32 (7): 1567–80. doi:10.1111/mec...

proteins that according to Kimura would indicate an impossibly high genetic load if the changes were caused by natural selection. The paper was initially...

of inbreeding Coefficient of relationship Natural selection Fitness Genetic load The term frequency usually refers to a number or count, but in this context...

A population bottleneck or genetic bottleneck is a sharp reduction in the size of a population due to environmental events such as famines, earthquakes...

as a courtesy associate professor. Sanford has argued for genetic load in his book Genetic Entropy & the Mystery of the Genome (2005, 2008). In it, he...

Jon; Toni, Ivan; Zilles, Karl; Falkai, Peter; Schneider, Frank (2004). "Genetic Load on Amygdala Hypofunction During Sadness in Nonaffected Brothers of Schizophrenia...

late-acting deleterious mutations was correspondingly small. Therefore, a genetic load of late-acting deleterious mutations could be substantial at mutation–selection...

Genetic erosion (also known as genetic depletion or genomic erosion) is a process where the limited gene pool of an endangered species diminishes even...

This is sometimes referred to as genetic load, in this case it is a special kind of load known as segregational load. Crow and Kimura showed that at equilibrium...