Granzyme B (GrB) is one of the serine protease granzymes most commonly found in the granules of natural killer cells (NK cells) and cytotoxic T cells....

Granzymes are serine proteases released by cytoplasmic granules within cytotoxic T cells and natural killer (NK) cells. They induce programmed cell death...

unique and parallel to that of Granzyme B, although some substrates such as PARP-1 and lamin B are shared with Granzyme B. Substrates of GzmA include Pro-IL-1β...

protease Granzyme B, cytotoxic T-cells and NK cells are able to induce apoptosis in target cell. SCs produce PI-9 that irreversibly bonds Granzyme B and inhibits...

influence of blood pressure. Other reports have suggested the serine protease granzyme B may contribute to aortic aneurysm rupture through the cleavage of decorin...

plasma membrane pore model was challenged when research revealed that granzyme B could undergo endocytosis independently of perforin. Moreover, experiments...

beta (TGF-β). Another known mechanism is the production of cytotoxic Granzyme B. Bregs also express various inhibitory surface markers such as programmed...

Granzyme B is a serine protease that in humans is encoded by the GZMB gene. Granzyme B is expressed by cytotoxic T lymphocytes (CTL) and natural killer...

IFN-y cytokine and granzyme B secretion in order to assess cytotoxic T-cell responses. Both of these are used for cancer research. With B-cell FluoroSpot...

Regulatory T cells can produce Granzyme B, which in turn can induce apoptosis of effector cells. Regulatory T cells from Granzyme B deficient mice are reported...

the cytotoxic granule protease granzyme B. In doing so, Serpin B9 may protect against inadvertent release of granzyme B and premature or unwanted activation...

collectively termed granzymes and include 4 distinct gene products: granzyme A, granzyme B, granzyme H, and Met-ase, also known as granzyme M. GRCh38: Ensembl...

granules that contains proteins involved in cell lysis such as perforin and granzyme B. Flow cytometry is also commonly used. Bone marrow involvement in this...

angiogenesis, blood coagulation, abolishing detachment activity by GrB (Granzyme B), and tumour metastasis. HS has also been shown to serve as cellular...

also play role in the protection against malignancies. TRM cells express granzyme B which helps limit the spread of pathogens at the site of infection. Also...

associated with the macromolecular complex of granzymes and perforin, and serves as a scaffold for the granzyme and perforin in granule-mediated apoptosis...

T-cell can attach itself to a membrane, facilitating the release of granzyme B. Granzyme B perforates the target cell membrane and in turn allows the release...

and mice IELs express higher levels of CD103, activation marker CD69, granzyme B and perforin cytolytic granules. CD25 expression is lower in comparison...

television production company Gamma-ray burst, an astronomical event Granzyme B (GrB), serine protease most commonly found in the granules of NK cells and...

h-CCPX)". Waterhouse NJ, Trapani JA (2007). "H is for helper: granzyme H helps granzyme B kill adenovirus-infected cells". Trends Immunol. 28 (9): 373–5...

lymphocytes, which target neurons and astrocytes. These immune cells release granzyme B and perforin, a enzyme and protein that kill cells. This leads to direct...

cell death through release of a number of molecules, including perforin, granzyme B, and granulysin. Other agents, including tumor necrosis factor alpha and...

[permanent dead link] Veugelers K, Motyka B, Frantz C, Shostak I, Sawchuk T, Bleackley R (2004). "The granzyme B-serglycin complex from cytotoxic granules...

variety of other caspases. The Serp-2 gene is also capable of inhibiting granzyme B, a cysteine protease.: 161  Myxoma virus is also capable of producing...

through its association with a protein complex that forms apoptosome, or by granzyme B, or via the death receptor pathways. Autoproteolysis takes place in some...

membrane Biological process innate immune response positive regulation of granzyme B production immune system process leukocyte migration adaptive immune response...

activity due to impaired expression of associated molecules such as IFN-γ, granzyme B or perforin impaired proliferation in response to antigenic stimulation...

is encoded by the SERPINB9 gene. Serpin B9 is an inhibitor of Granzyme B (GzmB). GzmB is a potent cytotoxic molecule that is secreted by cytotoxic T...

increases cytotoxic activity by increasing the expression of perforin, granzyme B, Fas ligand, and TNF. In T cells, the activation of the JNK pathway by...

express markers characteristic of NK and/or T cells (e.g. CD2, CD56, CD38), granzyme B, perforin, TIA1, and, with respect to T cells which are commonly gamma...