A knockout mouse, or knock-out mouse, is a genetically modified mouse (Mus musculus) in which researchers have inactivated, or "knocked out", an existing...

A knockout mouse is a genetically modified mouse that has had one or more of its genes made inoperable through a gene knockout. Experimental mouse model...

William; Rosen, Barry; et al. (2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature. 474 (7351): 337–342. doi:10...

create knockout mice. With the aid of gene targeting, numerous mouse genes have been shut down, leading to the creation of hundreds of distinct mouse models...

postdoctoral fellow Arthur T Sands. The company has used its patented mouse gene knockout technology and extensive in vivo screening capabilities to study...

The International Knockout Mouse Consortium (IKMC) is a scientific endeavour to produce a collection of mouse embryonic stem cell lines that together...

reducing the cost of research and experiments. The most common type is the knockout mouse, where the activity of a single (or in some cases multiple) genes are...

Nude mouse SCID mouse NOG mouse NSG mouse Mouse model of colorectal and intestinal cancer Mouse models of breast cancer metastasis Knockout mouse Chuprin...

Capecchi and Oliver Smithies, for his work in the development of the knockout mouse and the related technology of gene targeting, a method of using embryonic...

therefore it is used even more. In 1993 the first C57BL/6 gene targeted knockout mouse was published by a group at Hoffmann-La Roche in Switzerland. In 2013...

LIT-001 reduces social deficits in a mouse model of autism, specifically the μ-opioid receptor knockout mouse model. It was the first small-molecule...

HG; Gonzalez, FJ; Nebert, DW (2006). "Oral Benzo[a]pyrene in Cyp1 knockout mouse lines: CYP1A1 important in detoxication, CYP1B1 metabolism required...

Ramberg Capecchi (born 1937), and Oliver Smithies (1925–2017), U.S. – Knockout mouse, Gene targeting Ole Evinrude (1877–1934), Norway – outboard motor Charles...

that are unavailable in the mouse. Knockout rat models can also complement existing transgenic mouse models. Comparing mouse and rat mutants can facilitate...

this holds in vivo over longer time periods is not clear. The ABCR -/- knockout mouse has delayed dark adaptation but normal final rod threshold relative...

modeling. The National Institutes of Health (NIH) funds phase 2 of the Knockout Mouse Production and Phenotyping Project (KOMP2). Researchers link mutations...

ultimately lead to cancer due to the loss of function as a sensor. Runx3 null mouse gastric mucosa exhibits hyperplasia due to stimulated proliferation and...

conditional knockout mouse lines deficient in glycan-binding proteins or glycosyltransferases. All Core F strains are now archived at the Mutant Mouse Regional...

A nude mouse is a laboratory mouse from a strain with a genetic mutation that causes a deteriorated or absent thymus, resulting in an inhibited immune...

the production of a knockout mouse. This is accomplished through the administration of one or more transgenes into a fertilized mouse oocyte’s pronucleus...

activation by beta-endorphin in pons/medulla of the mu-opioid receptor knockout mouse". Neuroscience. 115 (3): 715–721. doi:10.1016/s0306-4522(02)00486-4...

KOMP 104.9 Radio Compa, an album by Akwid Knockout Mouse Program (KOMP), part of the International Knockout Mouse Consortium Comp (disambiguation) This disambiguation...

"Schneckenbecken dysplasia". In 2007, Hiraoka et al. created an SLC35D1-knockout mouse model, said experiment revealed that while mice heterozygous for the...

hormone-releasing hormone (GHRH) analog, normalizes growth in the GHRH knockout mouse". American Journal of Physiology. Endocrinology and Metabolism. 291...

International Mouse Phenotyping Consortium (IMPC) is an international scientific endeavour to create and characterize the phenotype of 20,000 knockout mouse strains...

disorder. A mutation in one gene (TMEM63B) was identified in a large knockout mouse study as likely to result in disease in humans. In two patients, a small...

Sanger Institute, the project uses knockout mice most of which were generated by the International Knockout Mouse Consortium. For each mutant line, groups...

phenotype. Foxp3 expression is not affected by loss of CD83 in a CD83 knockout mouse. In contrast, CD83 seems important for peripheral Treg cell induction...

Bradley A, Bucan M, Capecchi M, Collins FS, et al. (September 2004). "The knockout mouse project". Nature Genetics. 36 (9): 921–4. doi:10.1038/ng0904-921. PMC 2716027...

mice, the DNA is inserted into mouse embryonic stem cells in culture. Cells with the insertion can contribute to a mouse's tissue via embryo injection....