ligase 4 also DNA ligase IV, is an enzyme that in humans is encoded by the LIG4 gene. DNA ligase 4 is an ATP-dependent DNA ligase that joins double-strand...

LIG4 syndrome (also known as Ligase IV syndrome) is an extremely rare condition caused by mutations in the DNA Ligase IV (LIG4) gene. Some mutations in...

are associated with dysfunctional NHEJ. Hypomorphic mutations in LIG4 and XLF cause LIG4 syndrome and XLF-SCID, respectively. These syndromes share many...

Cernunnos or XLF). DNA ligase 4 (Lig4) has a highly specific role in the repair of double-strand breaks by NHEJ. Lig4 deficiency in the mouse causes a...

quiescence. DNA ligase 4 (Lig4) has a highly specific role in the repair of double-strand breaks by non-homologous end joining (NHEJ). Lig4 deficiency in the...

poisoning Sako disease (Myelodysplastic-cytosis) Chronic radiation sickness LIG4 syndrome The mechanism of pancytopenia involves either haemopoiesis itself...

brain cancers.[citation needed] Similarly, epigenetic downregulation of LIG4 occurs in 82% of colorectal cancers and epigenetic downregulation of NEIL1...

terminus of a DNA nick; (iii) phosphodiester bond formation. Unlike LIG1 and LIG4 family members that are found in almost all eukaryotes, LIG3 family members...

colorectal cancers and 50% of brain cancers. Promoter hypermethylation of LIG4 occurs in 82% of colorectal cancers. Promoter hypermethylation of NEIL1 occurs...

deficiency Janus kinase 3 deficiency Leukocyte adhesion molecule deficiency LIG4 syndrome Myeloperoxidase deficiency Neutrophil immunodeficiency syndrome...

(loquacious), r2d2 (r2d2 protein), ku70 (ku heterodimer protein gene) and lig4 (ligase4) were targeted to modify the genome of Aedes aegypti. The new mutant...

brain cancers. In addition, promoter hypermethylation of DNA repair genes LIG4, NEIL1, ATM, MLH1 or FANCB occurs at frequencies of between 33% and 82% in...

ani syndrome Leydig cell hypoplasia Liddle's syndrome Liebenberg syndrome LIG4 syndrome Lima syndrome Limb girdle syndrome Limber tail syndrome Limb–mammary...

HGNC:6597 P42702 8712 LIG1 HGNC:6598 P18858 8713 LIG3 HGNC:6600 P49916 8714 LIG4 HGNC:6601 P49917 8715 LILRA1 HGNC:6602 O75019 8716 LILRA2 HGNC:6603 Q8N149...

immunodeficiency, radiation sensitivity, and developmental abnormalities,  LIG4 syndrome (Ligase IV syndrome) is a rare disease associated with mutations...

horse dung". 7 November 2014. Efficient gene targeting in ΔCc.ku70 or ΔCc.lig4 mutants of the agaricomycete Coprinopsis cinerea. Lcc1 and Lcc5 are the main...

proteins containing this domain include: BARD1; BRCA1 CTDP1; TDT or DNTT ECT2 LIG4 MCPH1; MDC1 NBN PARP1; PARP4; PAXIP1; PES1 REV1; RFC1; TOPBP1; TP53BP1; XRCC1...

quiescence. DNA ligase 4 (Lig4) has a highly specific role in the repair of double-strand breaks by non-homologous end joining (NHEJ). Lig4 deficiency in the...

is important for the development of the immune response. She also studied LIG4-mutant mice and how exposure to oxygen increases the number of double-stranded...

growth, and LigB. In mammals, including human 3 genes, namely Lig1, Lig3, Lig4 were identified. All eukaryotes contain multiple types of DNA ligases encoded...

is with LIG4, a human gene that encodes the protein DNA Ligase IV. Two experiments in a publication of 1030 unique reactions support the LIG4-CCDC176...

in vivo complementation of the growth of yeast cells deleted for CDC9 and LIG4". Nucleic Acids Research. 27 (20): 3953–63. doi:10.1093/nar/27.20.3953. PMC 148661...

yeast Nej1, Lif1 and Dnl4 proteins and comparison to human XLF, XRCC4 and Lig4". DNA Repair. 6 (10): 1507–16. doi:10.1016/j.dnarep.2007.04.014. PMC 2064958...

telangectasia Artemis deficiency Immunodeficiency 26 (PKCS gene deficiency) LIG4 syndrome Nijmegen breakage syndrome Severe combined immunodeficiency with...

FANC proteins also interacts with BRCA1. FANC proteins also interacts with LIG4. FANC proteins also interacts with DNA-PKcs. FANC proteins also interacts...

Kwon YI, Osakabe K, Toki S (December 2012). "Suppression of Ku70/80 or Lig4 leads to decreased stable transformation and enhanced homologous recombination...

breaks. The DNA repair defect was traced to mutations in the DNA ligase IV LIG4 gene. This finding suggests that the molecular basis for at least a subset...

syndrome; 609265; CHEK2 Li–Fraumeni-like syndrome; 151623; TP53 LIG4 syndrome; 606593; LIG4 Limb-mammary syndrome; 603543; TP63 Lipase deficiency, combined;...

gene sequencing.[citation needed] Ataxia telangectasia Artemis deficiency LIG4 syndrome Nijmegen breakage syndrome Severe combined immunodeficiency with...

the three various mammalian ligase enzymes were tested: Lig1, Lig3, and Lig4. Using knockout models in the CH12F3 mouse B-lymphocyte cell line, research...