Mevalonate kinase deficiency (MKD) is an autosomal recessive metabolic disorder that disrupts the biosynthesis of cholesterol and isoprenoids. It is a...

Mevalonate kinase is an enzyme (specifically a kinase) that in humans is encoded by the MVK gene. Mevalonate kinases are found in a wide variety of organisms...

such as osteoporosis) A number of diseases affect the mevalonate pathway: Mevalonate Kinase Deficiency Mevalonic Aciduria Hyperimmunoglobulinemia D Syndrome...

North Macedonia, ISO 3166-1 alpha-3 code and IOC country code Mevalonate kinase deficiency, a metabolic disorder mkd (software), a documentation extractor...

(HIDS). This is now (along with mevalonic aciduria) defined as a mevalonate kinase deficiency 260920 MVK TNF receptor associated periodic syndrome (TRAPS)...

periodic syndrome (TRAPS), hyperimmunoglobulin D syndrome (HIDS)/mevalonate kinase deficiency (MKD), and familial mediterranean fever (FMF). In June 2020,...

antagonist deficiency (DITRA), Sweet syndrome or neutrophilic panniculitis) Inflammasome activation (Mevalonate kinase deficiency or Muckle–Wells...

in two additional autoinflammatory recurrent fever syndromes: mevalonate kinase deficiency (hyper-immunoglobulin D syndrome, or HIDS) and tumor necrosis...

receptor associated periodic syndrome (TRAPS) Hyper-IgD syndrome (Mevalonate kinase deficiency) CIAS1-related diseases: Muckle–Wells syndrome Familial cold...

encompasses both hereditary types (familial Mediterranean fever, mevalonate kinase deficiency, TNF receptor associated periodic syndrome, cryopyrin-associated...

competitively inhibiting HMG-CoA reductase, the rate-limiting enzyme of the mevalonate pathway. Because statins are similar in structure to HMG-CoA on a molecular...

classified mevalonate diphosphate decarboxylase as an enzyme in the GHMP kinase family (galactokinase, homoserine kinase, mevalonate kinase, and phosphomevalonate...

Familial Mediterranean fever, Hyper-IgD syndrome also known as Mevalonate kinase deficiency, and TNF receptor associated periodic syndrome (TRAPS), and a...

unresponsive, mut-0 Methylmalonyl-Coenzyme A mutase deficiency Methemoglobinemia Mevalonate kinase deficiency Mevalonicaciduria Meyenburg–Altherr–Uehlinger...

Hyperimmunoglobulin D syndrome in 50% of cases is associated with mevalonate kinase deficiency which can be measured in the leukocytes.[citation needed] There...

its original members: galactokinase, homoserine kinase, mevalonate kinase, and phosphomevalonate kinase. Members of the GHMP superfamily have great three-dimensional...

dolichol, from Ancient Greek δόλιχος (dolichos, "long"). Dolichol kinase Polyprenols Mevalonate inhibition#Dolichol Inhibition Fedorow, Heidi; Pickford, Russell;...

(plague) Controls ASC-mediated apoptosis Familial Mediterranean fever (FMF), mevalonate kinase deficiency (MKD), hyperimmunoglobulinemia D syndrome (HIDS)...

cloning of MEV, a mutant protein that facilitates cellular uptake of mevalonate, and identification of the point mutation responsible for its gain of...

conversion of 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) to mevalonate, this is an early step in the mevalonate pathway catalyzed by HMG-CoA reductase. Through a...

acetoacetate by HMG-CoA lyase or used in the production of cholesterol via the mevalonate pathway. HMB is synthesized in the human body through the metabolism of...

– that the syndrome was due to mutations of the gene encoding for mevalonate kinase, an enzyme in the cholesterol synthesis pathway. Independently – and...

acetoacetate by HMG-CoA lyase or used in the production of cholesterol via the mevalonate pathway. Leucine is an essential amino acid in the diet of animals because...

animals and archaea, the mevalonate pathway produces these compounds from acetyl-CoA, while in plants and bacteria the non-mevalonate pathway uses pyruvate...

inhibit TNF-α, IL-1β, and IL-6 in rat microglia. This shows that the mevalonate pathway plays a role in controlling the expression of cytokines in microglia...

+ H+, mevalonate forms. Mevalonate then undergoes three series of reactions with one ATP dedicated to each to form mevalonate-5-PP. Mevalonate-5-PP then...

Pitera DJ, Withers ST, Newman JD, Keasling JD (July 2003). "Engineering a mevalonate pathway in Escherichia coli for production of terpenoids". Nature Biotechnology...

many differing pathways; methylerythritol phosphate (MEP), cytosolic mevalonate (MEV), or deoxyxylulose phosphate pathway (DOXP) to name a few. In addition...