• Thumbnail for Nonsense-mediated decay
    Nonsense-mediated mRNA decay (NMD) is a surveillance pathway that exists in all eukaryotes. Its main function is to reduce errors in gene expression by...
    16 KB (2,066 words) - 06:36, 27 December 2023
  • Thumbnail for Messenger RNA
    subject to surveillance by nonsense-mediated decay (NMD), which checks for the presence of premature stop codons (nonsense codons) in the message. These...
    49 KB (5,922 words) - 00:21, 9 May 2024
  • nonsense-mediated mRNA decay pathway (NMD); the nonstop mediated mRNA decay pathways (NSD); and the no-go mediated mRNA decay pathway (NGD). Nonsense-mediated...
    29 KB (3,394 words) - 21:28, 16 March 2024
  • Thumbnail for Exon junction complex
    splicing, but along with Y14, it also takes part in the process of nonsense-mediated decay in eukaryotes. SRm160 is another coactivator that has been proposed...
    21 KB (2,530 words) - 04:33, 28 May 2024
  • Thumbnail for Eukaryotic translation termination factor 1
    recognition in translation, termination of translation, and nonsense mediated mRNA decay via the SURF complex. All cells need to make proteins through...
    43 KB (5,515 words) - 19:48, 27 May 2024
  • Thumbnail for Nuclear cap-binding protein complex
    ways that it does this quality control is through nonsense-mediated decay. Nonsense-mediated decay is when faulty mRNA's that have stop codons too early...
    12 KB (1,489 words) - 04:47, 22 December 2023
  • Thumbnail for UPF1
    between the nonsense-mediated mRNA decay pathway factor human upf1 (up-frameshift protein 1) and essential nonsense-mediated mRNA decay factors in HeLa...
    11 KB (1,401 words) - 22:24, 16 March 2024
  • Thumbnail for SR protein
    alternative pre-mRNA splicing, mRNA export, genome stabilization, nonsense-mediated decay, and translation. SR proteins alternatively splice pre-mRNA by...
    27 KB (3,445 words) - 02:41, 3 December 2023
  • types of situations with nonsense mutations occur a lot less frequently than the deleterious outcomes. Nonsense-mediated mRNA decay Despite an expected tendency...
    25 KB (2,870 words) - 22:43, 9 March 2024
  • Thumbnail for Non-stop decay
    In contrast to nonsense-mediated decay (NMD), polypeptides do not release from the ribosome, and thus, NSD seems to involve mRNA decay factors distinct...
    7 KB (1,014 words) - 04:04, 10 June 2023
  • Thumbnail for UPF3B
    between the nonsense-mediated mRNA decay pathway factor human upf1 (up-frameshift protein 1) and essential nonsense-mediated mRNA decay factors in HeLa...
    9 KB (1,176 words) - 23:46, 4 September 2022
  • Thumbnail for UPF3A
    between the nonsense-mediated mRNA decay pathway factor human upf1 (up-frameshift protein 1) and essential nonsense-mediated mRNA decay factors in HeLa...
    9 KB (1,146 words) - 23:03, 6 November 2022
  • Masturbation Day National Missile Defense Neuromuscular disease New media Nonsense mediated decay, a mechanism of messenger RNA surveillance Northern Marianas descent...
    532 bytes (84 words) - 11:55, 28 January 2024
  • Thumbnail for UPF2
    between the nonsense-mediated mRNA decay pathway factor human upf1 (up-frameshift protein 1) and essential nonsense-mediated mRNA decay factors in HeLa...
    11 KB (1,292 words) - 02:17, 24 December 2023
  • partially completed polypeptide or degradation of the mRNA by nonsense-mediated decay. The redundancy of tRNA genes makes sure that such mutation would...
    5 KB (627 words) - 10:53, 15 September 2022
  • errors explains why most splice variants are rapidly degraded by nonsense-mediated decay. The presence of sloppy binding sites within genes causes splicing...
    46 KB (5,770 words) - 11:27, 29 May 2024
  • Thumbnail for Dopamine receptor D3
    encode different isoforms, although some variants may be subject to nonsense-mediated decay (NMD). Alpha-synuclein (α-Syn) aggregation via Lewy bodies inclusion...
    28 KB (3,175 words) - 04:10, 4 January 2024
  • length by increasing euchromatin formation. On the other hand, nonsense-mediated decay factor enrichment at telomeres may exist to prevent TERRA inhibition...
    3 KB (312 words) - 22:54, 9 April 2024
  • Thumbnail for SMG7
    nonsense mediated mRNA decay factor (C. elegans)". Yang L, Kraft VA, Pfeiffer S, Merl-Pham J, Bao X, An Y, et al. (June 2020). "Nonsense-mediated decay...
    5 KB (588 words) - 20:13, 8 April 2022
  • pseudogene because all associated transcripts are candidates for nonsense-mediated decay (NMD). Rahim MM, Tu MM, Mahmoud AB, Wight A, Abou-Samra E, Lima...
    4 KB (336 words) - 23:31, 6 September 2021
  • Thumbnail for Messenger RNA decapping
    A number of specific decay pathways exist that recognize aberrant messages and promote their decapping. Nonsense mediated decay recognizes premature stop...
    4 KB (452 words) - 01:40, 10 September 2021
  • marked by exon junction complexes which in the cytosol can trigger nonsense mediated decay if the exon-exon junction is more than 50-55 nt downstream of the...
    8 KB (1,048 words) - 11:27, 22 February 2024
  • Thumbnail for EIF4A3
    eIF4AIII is recruited to the mRNA during splicing and functions in nonsense-mediated decay". Proc. Natl. Acad. Sci. U.S.A. 101 (12): 4118–23. Bibcode:2004PNAS...
    11 KB (1,125 words) - 01:19, 29 March 2024
  • Thumbnail for PABPC1
    high translational activity. PABPC1 is also associated with nonsense-mediated mRNA decay (NMD). PABPC1 binds to the poly(A) tail and interact with eIF4G...
    14 KB (1,663 words) - 02:04, 8 April 2024
  • Thumbnail for DCP2
    of a human decapping complex associated with hUpf proteins in nonsense-mediated decay". Molecular and Cellular Biology. 22 (23): 8114–8121. doi:10.1128/MCB...
    7 KB (799 words) - 21:38, 2 December 2023
  • Thumbnail for P2RX7
    encode different isoforms have been identified although some fit nonsense-mediated decay criteria. The receptor is found in the central and peripheral nervous...
    31 KB (3,358 words) - 00:58, 27 April 2024
  • Thumbnail for ARGLU1
    containing an alternative exon that targets the transcript for nonsense mediated decay. Furthermore, ARGLU1 contains a long, highly evolutionarily conserved...
    2 KB (274 words) - 01:54, 27 March 2022
  • Thumbnail for SMG6
    single-stranded DNA in telomere maintenance and single-stranded RNA in nonsense-mediated mRNA decay (NMD). The SMG6 gene also contains one of 27 SNPs associated...
    14 KB (1,738 words) - 01:26, 3 December 2023
  • Thumbnail for DCP1A
    decapping enzyme form a decapping complex, which interacts with the nonsense-mediated decay factor hUpf1 and may be recruited to mRNAs containing premature...
    8 KB (874 words) - 20:18, 27 July 2022
  • Thumbnail for NeuN
    Cytoplasmic Isoforms Differentially Regulate Alternative Splicing and Nonsense-Mediated Decay of Rbfox2". PLOS ONE. 6 (6): e21585. Bibcode:2011PLoSO...621585D...
    8 KB (962 words) - 18:11, 22 January 2023