Platelet-derived growth factor (PDGF) is one among numerous growth factors that regulate cell growth and division. In particular, PDGF plays a significant...
24 KB (2,882 words) - 15:04, 24 May 2025
Platelet-derived growth factor receptors (PDGF-R) are cell surface tyrosine kinase receptors for members of the platelet-derived growth factor (PDGF) family...
13 KB (1,563 words) - 09:00, 13 March 2024
Platelet-derived growth factor receptor A, also termed CD140a, is a receptor located on the surface of a wide range of cell types. The protein is encoded...
29 KB (3,358 words) - 18:48, 22 June 2025
epidermal growth factor receptor (EGFR; ErbB-1; HER1 in humans) is a transmembrane protein that is a receptor for members of the epidermal growth factor family...
60 KB (6,879 words) - 01:06, 1 March 2025
Brain-derived neurotrophic factor (BDNF) Nerve growth factor (NGF) Neurotrophin-3 (NT-3) Neurotrophin-4 (NT-4) Placental growth factor (PGF) Platelet-derived...
10 KB (1,131 words) - 18:45, 6 May 2025
Fibroblast growth factor receptor 1 (FGFR-1), also known as basic fibroblast growth factor receptor 1, fms-related tyrosine kinase-2 / Pfeiffer syndrome...
44 KB (5,007 words) - 01:23, 16 July 2025
fibronectin, platelet-derived growth factor, and chemotactic agents. Delta granules, or dense bodies, contain ADP, calcium, and serotonin, which are platelet-activating...
71 KB (8,529 words) - 10:45, 12 July 2025
1991). "trkB encodes a functional receptor for brain-derived neurotrophic factor and neurotrophin-3 but not nerve growth factor". Cell. 65 (5): 885–893...
50 KB (5,881 words) - 13:31, 5 May 2025
Epidermal growth factor (EGF) is a protein that stimulates cell growth and differentiation by binding to its receptor, EGFR. Human EGF is 6-kDa and has...
17 KB (1,716 words) - 17:10, 9 July 2025
PDGFA (redirect from Platelet-derived growth factor subunit A)
Platelet-derived growth factor subunit A is a protein that in humans is encoded by the PDGFA gene. The protein encoded by this gene is a member of the...
8 KB (1,108 words) - 23:22, 16 March 2025
is a small molecule tyrosine-kinase inhibitor, targeting vascular endothelial growth factor receptor, fibroblast growth factor receptor and platelet derived...
36 KB (3,141 words) - 01:15, 30 June 2025
proto-oncogenic c-Met receptor. Hepatocyte growth factor is secreted by platelets, and mesenchymal cells and acts as a multi-functional cytokine on cells of...
23 KB (2,623 words) - 04:15, 15 July 2025
maturation factor, insulin, insulin-like growth factor 1 (IGF-1), vascular endothelial growth factor (VEGF), fibroblast growth factor (FGF), platelet-derived growth...
16 KB (1,784 words) - 04:08, 6 January 2024
Hepatocyte growth factor receptor (HGF receptor) is a protein that in humans is encoded by the MET gene. The protein possesses tyrosine kinase activity...
59 KB (6,731 words) - 17:30, 16 July 2025
endothelial growth factor A (VEGF-A) is a protein that in humans is encoded by the VEGFA gene. This gene is a member of the platelet-derived growth factor (PDGF)/vascular...
24 KB (3,053 words) - 21:44, 26 May 2025
VEGF receptors (VEGFRs) are receptors for vascular endothelial growth factor (VEGF). There are three main subtypes of VEGFR, numbered 1, 2 and 3. Depending...
8 KB (758 words) - 08:47, 24 June 2025
PDGFRB (category Tyrosine kinase receptors)
Platelet-derived growth factor receptor beta is a protein that in humans is encoded by the PDGFRB gene. Mutations in PDGFRB are mainly associated with...
31 KB (3,407 words) - 06:53, 15 July 2025
Nerve Growth Factor-inducible, a protein whose expression is induced by NGF Neurotrophin Nerve growth factor receptor Growth factor Brain-derived neurotrophic...
27 KB (3,118 words) - 09:07, 12 July 2025
PDGFB (redirect from Platelet-derived growth factor beta polypeptide)
Platelet-derived growth factor subunit B is a protein that in humans is encoded by the PDGFB gene. The protein encoded by this gene is a member of the...
3 KB (434 words) - 18:15, 16 July 2025
To be specific, VEGF is a sub-family of growth factors, the platelet-derived growth factor family of cystine-knot growth factors. They are important signaling...
40 KB (4,578 words) - 12:30, 10 September 2024
Receptor tyrosine kinases (RTKs) are the high-affinity cell surface receptors for many polypeptide growth factors, cytokines, and hormones. Of the 90...
28 KB (3,078 words) - 17:48, 25 January 2025
Imatinib (category Non-receptor tyrosine kinase inhibitors)
myelodysplastic/myeloproliferative diseases associated with platelet-derived growth factor receptor gene rearrangements, aggressive systemic mastocytosis without...
72 KB (6,714 words) - 21:08, 29 May 2025
The fibroblast growth factor receptors (FGFR) are, as their name implies, receptors that bind to members of the fibroblast growth factor (FGF) family of...
8 KB (827 words) - 14:53, 16 April 2025
GRB2 (redirect from Growth factor receptor-bound protein 2)
Growth factor receptor-bound protein 2, also known as Grb2, is an adaptor protein involved in signal transduction/cell communication. In humans, the GRB2...
82 KB (9,401 words) - 17:27, 16 July 2025
Insulin-like growth factor 1 (IGF-1), also called somatomedin C, is a hormone similar in molecular structure to insulin which plays an important role in...
34 KB (4,517 words) - 04:50, 12 July 2025
stromal tumor (GIST) that harbor a platelet-derived growth factor receptor alpha (PDGFRA) exon 18 mutation. Avapritinib is a kinase inhibitor. Common side...
16 KB (1,218 words) - 20:03, 29 May 2025
A growth factor receptor is a receptor that binds to a growth factor. Growth factor receptors are the first stop in cells where the signaling cascade...
5 KB (591 words) - 23:31, 23 May 2025
Schering and Novartis. It inhibits all known VEGF receptors, as well as platelet-derived growth factor receptor-beta and c-kit, but is most selective for VEGFR-2...
7 KB (564 words) - 16:04, 9 January 2024
kinases and examples of these are platelet derived growth factor receptor (PDGFR) pathway and epidermal growth factor receptor (EGFR). Src contains at least...
21 KB (2,648 words) - 12:12, 26 July 2024
HER2 (redirect from Human epidermal growth factor receptor 2)
human epidermal growth factor receptor 1, or HER1. The Neu alias of HER2 derives its name from the parent glioblastoma cell line - a type of neural tumor...
43 KB (4,669 words) - 08:09, 15 July 2025