Protein–protein interactions (PPIs) are physical contacts of high specificity established between two or more protein molecules as a result of biochemical...
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Protein–protein interaction screening refers to the identification of Protein–protein interaction with high-throughput screening methods such as computer-...
6 KB (726 words) - 13:48, 18 November 2021
Two-hybrid screening (originally known as yeast two-hybrid system or Y2H) is a molecular biology technique used to discover protein–protein interactions (PPIs)...
47 KB (6,112 words) - 20:23, 24 May 2025
Protein–protein interaction prediction is a field combining bioinformatics and structural biology in an attempt to identify and catalog physical interactions...
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Zell A, Harter K, Wanke D (2013). "Screening for protein-DNA interactions by automatable DNA-protein interaction ELISA". PLOS ONE. 8 (10): e75177. Bibcode:2013PLoSO...
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to investigate protein–protein interactions which are the physical contacts of high specificity established between two or more protein molecules involving...
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contributed an understanding of protein folding and structure mediated by hydrophobic interactions. The first protein to have its amino acid chain sequenced...
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P53 (redirect from Protein P53)
p73alpha by SUMO-1. Two-hybrid screening with p73 identifies novel SUMO-1-interacting proteins and a SUMO-1 interaction motif". The Journal of Biological...
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receptors modeling, activation, interactions and virtual screening (1st ed.). Academic Press. Matthews, Jacqueline M. Protein Dimerization and Oligomerization...
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biology, a protein-fragment complementation assay, or PCA, is a method for the identification and quantification of protein–protein interactions. In the...
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The green fluorescent protein (GFP) is a protein that exhibits green fluorescence when exposed to light in the blue to ultraviolet range. The label GFP...
66 KB (7,627 words) - 08:51, 21 June 2025
detailed knowledge of protein structure and function, and advances in high-throughput screening, may greatly expand the abilities of protein engineering. Eventually...
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Protein–protein interactions can be designed using protein design algorithms because the principles that rule protein stability also rule protein–protein binding...
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are most likely to bind to a drug target, typically a protein receptor or enzyme. Virtual screening has been defined as "automatically evaluating very large...
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lead to development of protein-protein interaction (PPI) inhibitors, modulating binding between PRMT5 and the adaptor proteins. Furthermore, Asberry and...
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Affinity chromatography (section Recombinant proteins)
antibody, enzyme and substrate, receptor and ligand, or protein and nucleic acid binding interactions are frequently exploited for isolation of various biomolecules...
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of the protein furthest from the viral surface while the S2 regions form a flexible "stalk" containing most of the protein-protein interactions that hold...
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a protein receptor or enzyme. Pharmaceutical research employs docking techniques for a variety of purposes, most notably in the virtual screening of...
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form mesoscale punctuations in cells. In E. coli, binary protein-protein interaction screening have shown the potential existence of a bacterial purinosome...
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Docking (molecular) (category Protein structure)
out whether they can bind at the protein's active site, and are usually scalable to even protein-protein interactions. They are also much more amenable...
34 KB (4,015 words) - 21:27, 6 June 2025
Bimolecular fluorescence complementation (category Protein–protein interaction assays)
technology typically used to validate protein interactions. It is based on the association of fluorescent protein fragments that are attached to components...
46 KB (5,192 words) - 21:42, 24 June 2025
Phage display (category Protein–protein interaction assays)
study of protein–protein, protein–peptide, and protein–DNA interactions that uses bacteriophages (viruses that infect bacteria) to connect proteins with the...
38 KB (4,630 words) - 03:13, 22 June 2024
Huntingtin (redirect from Huntingtin protein)
epithelial polarity through its interaction with RAB11A. Huntingtin has been found to interact directly with at least 19 other proteins, of which six are used...
33 KB (3,723 words) - 16:43, 23 June 2025
Pappalysin-1 (redirect from Pregnancy-associated plasma protein A)
main substrate is insulin-like growth factor binding proteins. Pappalysin-1 is also used in screening tests for Down syndrome. PAPPA encodes a secreted metalloproteinase...
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part in protein-protein interactions, but it is not known for certain. In some proteins, it also contributes to the localization of each protein to a membrane...
21 KB (2,071 words) - 13:45, 14 June 2025
interact with promoter elements; it is brought to the site via protein-protein interactions that are the result of its different structural domains complexing...
52 KB (5,272 words) - 02:33, 25 May 2025
Protein crystallization is the process of formation of a regular array of individual protein molecules stabilized by crystal contacts. If the crystal is...
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gene. FAM46B contains one protein domain of unknown function, DUF1693. Yeast two-hybrid screening has identified three proteins that physically interact...
16 KB (1,637 words) - 03:03, 10 March 2024
2020-02-12. "About | rDock". Retrieved 2020-02-12. "Protein-ligand docking bioinformatics tools | Interaction analysis". omicX. Retrieved 2019-05-23....
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myelin sheath by participating in homotypic interactions with other myelin protein zero proteins. Myelin protein zero's extracellular domain binds to the...
19 KB (2,239 words) - 04:21, 16 May 2025