homolog C (S. cerevisiae), also known as RAD51C, is a protein which in humans is encoded by the RAD51C gene. The RAD51C protein is one of five paralogs of RAD51...
24 KB (2,984 words) - 07:06, 19 July 2025
higher plants. For example, study using rice has shown that the gene OsRAD51C is necessary for the accurate repair of DNA double-strand breaks during...
95 KB (8,758 words) - 01:32, 24 July 2025
repair (HRR) deficiencies as a result of mutations in BRCA1, BRCA2, PALB2, RAD51C, or RAD51D genes. "Saruparib - AstraZeneca". AdisInsight. Springer Nature...
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determined. RAD51L3 has been shown to interact with: Bloom syndrome protein, RAD51C, and XRCC2. GRCh38: Ensembl release 89: ENSG00000185379 – Ensembl, May 2017...
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FANCF, FANCG, FANCI, FANCJ (BRIP1), FANCL, FANCM, FANCN (PALB2), FANCO (RAD51C), FANCP (SLX4), FANCQ (XPF), FANCS (BRCA1), FANCT (UBE2T), FANCU (XRCC2)...
38 KB (4,140 words) - 05:47, 19 July 2025
cancers was found for DNA repair genes BRCA1, BRCA2, BARD1, PALB2, FANCC, RAD51C and RAD51D. Reduced ability to accurately repair DNA damages by homologous...
11 KB (1,419 words) - 19:38, 22 September 2024
Q96B01 13355 RAD51AP2 HGNC:34417 Q09MP3 13356 RAD51B HGNC:9822 O15315 13357 RAD51C HGNC:9820 O43502 13358 RAD51D HGNC:9823 O75771 13359 RAD52 HGNC:9824 P43351...
282 KB (17 words) - 09:28, 10 February 2025
Other genes that have been associated with ovarian cancer are BRIP1, MSH6, RAD51C and RAD51D. CDH1, CHEK2, PALB2 and RAD50 have also been associated with...
199 KB (21,276 words) - 23:45, 27 July 2025
FANCE, FANCF, FANCG, FANCI, FANCJ, FANCL, FANCM, FANCN, FANCP, FANCS, RAD51C, XPF 1:130,000 Fabry disease GLA (Xq22.1) P 1:117,000-476,000 Factor V Leiden...
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"Ovarian and Breast Cancer Risks Associated With Pathogenic Variants in RAD51C and RAD51D". Journal of the National Cancer Institute. 112 (12): 1242–50...
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(ATM, ATR, BRCA1, BRCA2, CDK12, CHEK2, FANCA, MLH1, MRE11A, NBN, PALB2, or RAD51C) were assessed prospectively using tumor tissue and/or circulating tumor...
17 KB (1,254 words) - 03:52, 14 July 2025
protein has been shown to form a stable heterodimer with the family member RAD51C, which further interacts with the other family members, such as RAD51, XRCC2...
9 KB (1,132 words) - 04:40, 15 July 2025
a DNA double-strand break, and also binds to RAD51C, a member of the RAD51 paralog complex RAD51B-RAD51C-RAD51D-XRCC2 (BCDX2). The BCDX2 complex is responsible...
18 KB (1,567 words) - 17:47, 17 July 2025
The paralogs form two identified complexes: BCDX2 (RAD51B-RAD51C-RAD51D-XRCC2) and CX3 (RAD51C-XRCC3). These two complexes act at two different stages of...
48 KB (5,526 words) - 19:40, 22 May 2025
checkpoint activation upon DNA damage RAD23B NM_002873 RAD50 NM_005732 RAD51C NM_002874 IST1 (locates to central dividing line of dividing cells) DAD1...
48 KB (4,613 words) - 03:06, 27 May 2025
In addition, the four paralogs of RAD51, consisting of RAD51B (RAD51L1), RAD51C (RAD51L2), RAD51D (RAD51L3), XRCC2 form a complex called the BCDX2 complex...
24 KB (3,093 words) - 08:12, 27 June 2025
three related paralogs: BCDX2 (RAD51B-RAD51C-RAD51D-XRCC2) while two paralogs form a second complex CX3 (RAD51C-XRCC3). These two complexes act at two...
15 KB (1,849 words) - 19:00, 16 July 2025
a DNA double-strand break, and also binds to RAD51C, a member of the RAD51 paralog complex RAD51B-RAD51C-RAD51D-XRCC2 (BCDX2). The BCDX2 complex is responsible...
12 KB (1,374 words) - 21:41, 15 July 2025
a DNA double-strand break, and also binds to RAD51C, a member of the RAD51 paralog complex RAD51B-RAD51C-RAD51D-XRCC2 (BCDX2). The BCDX2 complex is responsible...
41 KB (5,013 words) - 21:06, 15 June 2025
In addition, the four paralogs of RAD51, consisting of RAD51B (RAD51L1), RAD51C (RAD51L2), RAD51D (RAD51L3), XRCC2 form a complex called the BCDX2 complex...
73 KB (7,913 words) - 01:52, 19 July 2025
paralogs form a complex designated CX3 (RAD51C-XRCC3). Four paralogs form a second complex designated BCDX2 (RAD51B-RAD51C-RAD51D-XRCC2). These two complexes...
13 KB (1,745 words) - 07:47, 19 July 2025
Schinzel–Giedion syndrome: SETBP1 Fanconi anemia and related disorders: RAD51C Noonan syndrome: NRAS generalized lymph vessel dysplasia: CCBE1 brachydactyly-anonychia:...
2 KB (213 words) - 16:26, 18 February 2025
a DNA double-strand break, and also binds to RAD51C, a member of the RAD51 paralog complex RAD51B-RAD51C-RAD51D-XRCC2 (BCDX2). The BCDX2 complex is responsible...
24 KB (2,547 words) - 09:50, 9 June 2025
Tonin, Patricia N. (30 April 2022). "The Genetic and Molecular Analyses of RAD51C and RAD51D Identifies Rare Variants Implicated in Hereditary Ovarian Cancer...
91 KB (8,393 words) - 14:35, 28 July 2025
Recently his laboratory described the high resolution structure of the RAD51B-RAD51C-RAD51D-XRCC2 (BCDX2) complex using cryo-electron microscopy, and defined...
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associated with lower risk of breast cancer.[better source needed] Mutations in RAD51C confer an increased risk for breast and ovarian cancer. People who have...
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fever, AR; 249100; MEFV Fanconi anemia, complementation group 0; 613390; RAD51C Fanconi anemia, complementation group A; 227650; FANCA Fanconi anemia, complementation...
234 KB (18,877 words) - 18:07, 24 March 2025
Anup; Saxena, Sneha; Kaushal, Anjali; Nagaraju, Ganesh (1 February 2018). "RAD51C/XRCC3 Facilitates Mitochondrial DNA Replication and Maintains Integrity...
11 KB (814 words) - 02:22, 28 July 2025
a DNA double-strand break, and also binds to RAD51C, a member of the RAD51 paralog complex RAD51B-RAD51C-RAD51D-XRCC2 (BCDX2). The BCDX2 complex is responsible...
21 KB (2,456 words) - 16:33, 17 July 2025
RNF-113 is involved in interstrand DNA crosslink repair and interacts with a RAD51C homolog". PLOS ONE. 8 (3): e60071. Bibcode:2013PLoSO...860071L. doi:10.1371/journal...
21 KB (1,976 words) - 20:02, 23 July 2025