A receptor activated solely by a synthetic ligand (RASSL) or designer receptor exclusively activated by designer drugs (DREADD), is a class of artificially...

candidates targeted at GPCRs Receptor activated solely by a synthetic ligand, a technique for control of cell signaling through synthetic GPCRs TOG superfamily...

Dreadlocks, a hairstyle also known as dreads Anti Dread, Polish punk rock band Dred (disambiguation) Dredd (disambiguation) Receptor activated solely by a synthetic...

analyzed as a functional lesion. Synthetic ligand injection – A receptor activated solely by a synthetic ligand (RASSL) or Designer Receptor Exclusively...

fictional character from the Max Steele fictional universe Receptor activated solely by a synthetic ligand, also known as DREADD Judge Dredd (disambiguation)...

in a preclinical model of drug-resistant epilepsy, where seizures arise from a discrete part of the brain. Receptor activated solely by a synthetic ligand...

developing receptors activated solely by a synthetic ligand (DREADDs), a chemogenetic platform used to direct selective, dose-dependent activation of a specific...

SEGRAMs achieve their selectivity by triggering only a subset the glucocorticoid receptor mechanisms of action. Synthetic steroids with SEGRA-like properties...

form concentrating platforms after ligand binding activation for individual receptors. Lipid rafts have been found by researchers to be involved in many...

brain to enter a protective cycle, useful in preventing damage during ischemic shock. Synthetic thyroxine was first successfully produced by Charles Robert...

relatively small quantity can cause overdose. Fentanyl works by activating μ-opioid receptors. Fentanyl is sold under the brand names Actiq, Duragesic, and...

tazarotene, which is a treatment for psoriasis and acne, and in the preparation of SIB-1508Y, also known as Altinicline, a nicotinic receptor agonist. The alkynylation...

5-HT7 receptors. Except for the serotonin 5-HT3 receptor, a ligand-gated ion channel, all other 5-HT receptors are G-protein-coupled receptors (also called...

Drakopoulos A, Moianos D, Prifti GM, Zoidis G, Decker M (July 2022). "Opioid Ligands Addressing Unconventional Binding Sites and More Than One Opioid Receptor Subtype"...

as a stimulant and anxiolytic. As a pharmaceutical drug, it is used for smoking cessation to relieve withdrawal symptoms. Nicotine acts as a receptor agonist...

were based on a general mathematical model that describes the interaction between a polyvalent disordered ligand and a single receptor site It was later...

neurotransmitter. Although pregabalin is inactive at GABA receptors and GABA synapses, it acts by binding specifically to the α2δ-1 protein that was first...

hypothesized that DMT may be an endogenous ligand for the σ1 receptor. The concentration of DMT needed for σ1 activation in vitro (50–100 μmol/L) is similar...

sialyl-Lewis X, sialyl-Lewis A, and possible unknown ligands to adhesion of human urothelial cancer cells to activated endothelium". Urologia Internationalis...

terminal in a manner similar to but distinct from amphetamines. Sigma receptors are affected by cocaine, as cocaine functions as a sigma ligand agonist....

paracetamol exerts an anticonvulsant effect by activation of the TRPV1 receptors and a decrease in neuronal excitability by hyperpolarization of neurons. The exact...

solely with the antagonism of postsynaptic M1 receptors; currently no other receptor subtypes have been implicated. Peripheral muscarinic receptors are...

undergo metabolization via phosphorylation to become activated. Antisense oligonucleotides (ASO): synthetic oligonucleotides have been used in the treatment...

that angiotensin IV interacts with the HGF system through the c-Met receptor. Synthetic small molecule analogues of angiotensin IV with the ability to penetrate...

for every receptor and ligand coding gene in both coding sequences, as well as regulatory regions. Research on endogenous opioid receptors has focused...

distinguishes [synthetic cathinones (SCs)] from amphetamines is their negligible interaction with the trace amine associated receptor 1 (TAAR1). Activation of this...

estrogen, or an agonist of the estrogen receptors, the biological target of estrogens like estradiol. It is a synthetic and nonsteroidal estrogen of the stilbestrol...

structures attract ATR and eventually activates the checkpoint pathway. However, activation of Chk1 is not solely dependent on ATR, intermediate proteins...

enter a cell and activate its receptor. SHBG inhibits the function of these hormones. Thus, the local bioavailability of sex hormones is influenced by the...

stimulating receptor ligands. aAPCs loaded with cytokines have been found to stimulate T-cells to a higher degree than particles containing solely costimulatory...