• Recombinant factor VIIa (rfVIIa) is a form of blood factor VII that has been manufactured via recombinant technology. It is administered via an injection...
    20 KB (1,810 words) - 03:25, 28 June 2025
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    factor VII), which in turn activates factor IX and factor X. Using genetic recombination a recombinant factor VIIa (eptacog alfa) (trade names include...
    12 KB (1,376 words) - 17:01, 10 May 2024
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    plasma (FFP), vitamin K, prothrombin complex concentrates, or recombinant factor VIIa can be given to reverse the effect of warfarin. High doses of vitamin...
    56 KB (5,882 words) - 15:28, 23 May 2025
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    peptide, glycosylated and then cleaved by factor XIa (of the contact pathway) or factor VIIa (of the tissue factor pathway) to produce a two-chain form, where...
    34 KB (1,994 words) - 04:50, 15 September 2024
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    (only if bleeding is severe; risk of platelet alloimmunization) Recombinant factor VIIa, AryoSeven or NovoSeven FDA approved this drug for the treatment...
    10 KB (1,025 words) - 00:44, 12 October 2024
  • trials to understand more about the potential benefits and risks. Recombinant factor VIIa (rFVIIa) is not, as of 2012, supported by the evidence for most...
    20 KB (2,390 words) - 14:01, 14 March 2025
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    recombinant factor VIIa, and prothrombin complex concentrate (PCC) have been utilized with proven efficacy. Specifically with warfarin, four-factor PCC...
    81 KB (8,973 words) - 22:38, 29 May 2025
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    factor VIIa catalyzes the conversion of the inactive protease factor X into the active protease factor Xa. Together with factor VIIa, tissue factor forms...
    15 KB (1,878 words) - 00:38, 28 October 2024
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    kind of pregnancy, with others even using tranexamic acid and recombinant factor VIIa, which both minimize blood loss. Generally, unless the placenta...
    26 KB (2,859 words) - 18:40, 13 February 2025
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    trauma. For severe bleeding, for example from bleeding disorders, recombinant factor VIIa—a protein that assists blood clotting—may be appropriate. While...
    59 KB (6,713 words) - 21:44, 6 January 2025
  • Comparative thrombotic event incidence after infusion of recombinant factor VIIa versus factor VIII inhibitor bypass activity. J Thromb Haemost 2004; 2:1700-1708...
    10 KB (1,468 words) - 02:37, 30 June 2025
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    time (INR) every one to four weeks. Many other medications and dietary factors can interact with warfarin, either increasing or decreasing its effectiveness...
    94 KB (9,749 words) - 21:56, 30 June 2025
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    of whether there is poor nutritional status. Administration of recombinant factor VIIa has shown promise; however, this treatment approach requires further...
    37 KB (4,266 words) - 08:42, 24 May 2025
  • Thumbnail for Jeanne Lusher
    1980s. Lusher later conducted the first studies on the use of recombinant factor VIIa in the treatment of bleeding episodes in patients with hemophilia...
    14 KB (1,906 words) - 04:01, 1 June 2025
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    (September 2003). "A cell-based model of coagulation and the role of factor VIIa". Blood Rev. 17 (Suppl 1): S1–5. doi:10.1016/s0268-960x(03)90000-2. PMID 14697207...
    64 KB (6,646 words) - 08:40, 9 June 2025
  • of the Recombinant Factor VIIa in Rat Bone: Importance of the Gla‐Domain and Relevance to Factor IX, another Vitamin K‐Dependent Clotting Factor Mads Krogsgaard...
    19 KB (1,346 words) - 06:09, 25 February 2025
  • hemophilia A and rare coagulation disorders. Patterns of response to recombinant factor VIIa. J Thromb Haemost. 2004;2:102-10. Karger R, Egbring R, Weippert-Kretschmer...
    19 KB (2,428 words) - 07:42, 19 May 2024
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    activated factor VIIa (normally present in trace amounts in the blood), forming the extrinsic tenase complex. This complex further activates factor IX and...
    23 KB (2,460 words) - 16:35, 24 May 2025
  • 2024). "Current status and future prospects of activated recombinant coagulation factor VIIa, NovoSeven®, in the treatment of haemophilia and rare bleeding...
    16 KB (1,817 words) - 19:15, 9 June 2025
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    promptly to prevent further complications. In the case of DIC, recombinant activated factor VIIa is a quick way to address this issue. Serine proteinase inhibitor...
    25 KB (2,590 words) - 10:46, 30 June 2025
  • 2008, the company sold its MAXY-VII candidate drug, a recombinant form of clotting factor VIIa, to Bayer HealthCare. 2009 saw the formation of a joint...
    9 KB (880 words) - 04:14, 3 October 2024
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    Factor II (thrombin) (IIa), and also the activated form of Factor VII (VIIa) from the tissue factor pathway (formerly known as the extrinsic pathway). The...
    46 KB (5,439 words) - 22:38, 29 May 2025
  • investigator of a multinational multicenter testing program evaluating recombinant factor VIIa for this indication. Mayer predominantly uses invasive brain multimodality...
    17 KB (1,763 words) - 04:39, 2 June 2025
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    between intensive and less intensive blood pressure control. Giving Factor VIIa within 4 hours limits the bleeding and formation of a hematoma. However...
    43 KB (4,484 words) - 18:18, 10 June 2025
  • slow, tight-binding inhibitor of factor Xa with a Ki value of 0.3–0.6 nM but it also inhibits trypsin. Recombinant Antistasin can be produced by genetically...
    41 KB (4,916 words) - 17:03, 23 September 2024
  • factor va MeSH D23.119.325.300 – factor viia MeSH D23.119.350.300 – factor viiia MeSH D23.119.375.310 – factor ixa MeSH D23.119.400.315 – factor xa...
    86 KB (8,039 words) - 16:46, 9 February 2024
  • development and commercialization of three drug candidates, recombinant blood clotting factors VIIa, VIII and IX, the latter of which is in clinical trials...
    10 KB (885 words) - 10:13, 28 February 2024
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    of transfusions may be reduced if these patients are given recombinant human factor VIIa[medical citation needed] since the underlying cause are antibodies...
    24 KB (3,124 words) - 21:54, 29 May 2025