A selective progesterone receptor modulator (SPRM) is an agent that acts on the progesterone receptor (PR), the biological target of progestogens like...
47 KB (5,148 words) - 18:03, 24 April 2024
of selective estrogen receptor modulators Selective androgen receptor modulator Selective estrogen receptor degrader Selective receptor modulator Timeline...
56 KB (6,397 words) - 06:15, 13 January 2024
receptor modulators (SEGRMs) are typically nonsteroidal. The combined abbreviation of selective glucocorticoid receptor agonist and modulator is SEGRAM...
25 KB (2,554 words) - 13:39, 12 May 2024
The progesterone receptor (PR), also known as NR3C3 or nuclear receptor subfamily 3, group C, member 3, is a protein found inside cells. It is activated...
24 KB (2,847 words) - 20:58, 15 November 2023
Ulipristal acetate (category Selective progesterone receptor modulators)
It is in the selective progesterone receptor modulator (SPRM) class of medications. It works by preventing the effects of progesterone, therefore preventing...
29 KB (2,593 words) - 12:38, 8 July 2023
Classes of selective receptor modulators include: Selective androgen receptor modulator (SARM) Selective estrogen receptor modulator (SERM) Selective glucocorticoid...
2 KB (159 words) - 22:30, 4 October 2023
Antiprogestogen (redirect from Progesterone receptor antagonist)
antiprogestogens include the progesterone receptor weak partial agonist mifepristone, the selective progesterone receptor modulator (SPRM) ulipristal acetate...
4 KB (390 words) - 16:20, 2 November 2023
Selective androgen receptor modulators (SARMs) are a class of drugs that selectively activate the androgen receptor in specific tissues, promoting muscle...
74 KB (6,753 words) - 23:47, 22 April 2024
A receptor modulator, or receptor ligand, is a general term for a substance, endogenous or exogenous, that binds to and regulates the activity of chemical...
8 KB (982 words) - 02:36, 19 May 2024
allosteric modulator of the GABAA receptor. Progesterone and some of its metabolites, such as 5β-dihydroprogesterone, are agonists of the pregnane X receptor (PXR)...
123 KB (11,590 words) - 09:25, 11 May 2024
or an agonist of the progesterone receptor, the biological target of progestogens like endogenous progesterone. Progesterone also has antimineralocorticoid...
175 KB (18,960 words) - 04:20, 16 May 2024
VERU-024) – selective androgen receptor modulator for breast cancer [2] GSK-2881078 – selective androgen receptor modulator for cachexia [3] OPK-88004 (LY-2452473;...
14 KB (1,217 words) - 15:43, 15 March 2024
Telapristone (category Selective progesterone receptor modulators)
former code name CDB-4124), is a synthetic, steroidal selective progesterone receptor modulator (SPRM) related to mifepristone which is under development...
4 KB (193 words) - 09:12, 14 June 2022
GnRH modulator, or GnRH receptor modulator, also known as an LHRH modulator or LHRH receptor modulator, is a type of medication which modulates the GnRH...
6 KB (514 words) - 19:52, 27 March 2024
Vilaprisan (category Selective progesterone receptor modulators)
(developmental code name BAY-1002670) is a synthetic and steroidal selective progesterone receptor modulator (SPRM) which is under development by Bayer HealthCare...
4 KB (209 words) - 00:33, 24 January 2023
Trenbolone also binds with high affinity to the progesterone receptor, and binds to the glucocorticoid receptor as well. To prolong its elimination half-life...
19 KB (1,412 words) - 21:11, 27 May 2024
hence is an agonist of the progesterone receptor (PR), the biological target of progestogens like endogenous progesterone. It opposes the effects of estrogens...
185 KB (18,478 words) - 23:52, 23 May 2024
seals. Selective progesterone receptor modulators, such as progenta, have been under investigation. Another selective progesterone receptor modulator asoprisnil...
62 KB (6,905 words) - 11:11, 23 May 2024
5α-Dihydroprogesterone (category GABAA receptor positive allosteric modulators)
agonist of the progesterone receptor and a positive allosteric modulator of the GABAA receptor (albeit with an affinity for this receptor that is regarded...
10 KB (909 words) - 23:12, 9 November 2023
Sex-hormonal agent (redirect from Sex-hormone receptor modulator)
sex-hormonal agent, also known as a sex-hormone receptor modulator, is a type of hormonal agent which specifically modulates the effects of sex hormones and of their...
5 KB (357 words) - 23:19, 9 May 2024
Metapristone (category Selective progesterone receptor modulators)
major metabolite of mifepristone (RU-486, RU-38486) and a selective progesterone receptor modulator (SPRM) which itself was never marketed. It is formed from...
5 KB (384 words) - 20:59, 8 February 2023
Asoprisnil (category Selective progesterone receptor modulators)
developmental code name J-867) is a synthetic, steroidal selective progesterone receptor modulator that was under development by Schering and TAP Pharmaceutical...
3 KB (97 words) - 01:10, 26 April 2022
Allopregnanolone (category GABAA receptor positive allosteric modulators)
like progesterone, is known to be a negative allosteric modulator of nACh receptors, and also appears to act as a negative allosteric modulator of the...
50 KB (4,804 words) - 11:18, 26 January 2024
5α-Dihydrolevonorgestrel (category Selective progesterone receptor modulators)
progesterone receptor. In contrast to levonorgestrel, the compound has both progestogenic and antiprogestogenic activity, and hence has a selective progesterone...
7 KB (502 words) - 17:43, 11 November 2023
trenbolone acetate and its compounds bind with high affinity to the progesterone receptor. It has been assumed that gynecomastia as a result of trenbolone...
33 KB (3,293 words) - 14:14, 12 May 2024
Membrane progesterone receptors (mPRs) are a group of cell surface receptors and membrane steroid receptors belonging to the progestin and adipoQ receptor (PAQR)...
22 KB (2,417 words) - 07:41, 27 December 2023
(SARMs), Selective Estrogen Receptor Modulators (SERMs) and Selective Progesterone Receptor Modulators (SPRMs). The mechanism of action of SRMs may vary depending...
74 KB (6,676 words) - 23:26, 26 December 2023
estrogen receptor-sensitive or progesterone receptor-sensitive breast cancer, along with older classes of drugs like selective estrogen receptor modulators (SERMs)...
5 KB (440 words) - 13:49, 19 May 2024
Enobosarm (category Selective androgen receptor modulators)
MK-2866, and S-22, is a selective androgen receptor modulator (SARM) which is under development for the treatment of androgen receptor-positive breast cancer...
116 KB (12,929 words) - 10:48, 26 May 2024
Mifepristone (category Selective progesterone receptor modulators)
Chabbert-Buffet N, Meduri G, Bouchard P, Spitz IM (2005). "Selective progesterone receptor modulators and progesterone antagonists: mechanisms of action and clinical...
120 KB (11,102 words) - 20:05, 13 May 2024