(skewed X-inactivation). Unlike the random X-inactivation in placental mammals, inactivation in marsupials applies exclusively to the paternally-derived X chromosome...

Skewed X-chromosome inactivation (skewed X-inactivation) occurs when the X-inactivation of one X chromosome is favored over the other, leading to an uneven...

the phenotype, although differences in X-chromosome inactivation (known as skewed X-inactivation) can lead to varying degrees of clinical expression in...

translocation of the X inactivation complex on the X chromosome to an autosome. Mammalian X-chromosome inactivation is initiated from the X inactivation centre or...

These include random inactivation of one female X chromosome (as observed in humans and Mus musculus; this is called X-inactivation), a two-fold increase...

parent. X inactivation is a major factor in pentasomy X. X inactivation is the process through which genes in second (or higher) copies of the X chromosome...

that became a pseudogene. The inactive X chromosome is coated with this transcript, which is essential for the inactivation. X chromosomes lacking Xist will...

killed RNA interference, also called RNA inactivation, a system that regulates the activity of genes X-inactivation, also called lyonization, a process by...

2014) was an English geneticist best known for her discovery of X-chromosome inactivation, an important biological phenomenon. Mary Lyon was born on 15...

of a female's X-chromosomes, inactivation preferentially targets X-chromosomes inherited from a single parent, thus the remaining active X-chromosomes from...

investigators, that one of the X chromosomes underwent inactivation. In 1961, Mary Lyon proposed the random inactivation of one female X chromosome to explain...

mammals with more than one X chromosome, the genes on all but one X chromosome are not expressed; this is known as X inactivation. This happens in XXY males...

of X-inactivation, in which one of the X chromosomes is turned off at random in each cell in very early embryonic development. The inactivated X becomes...

X chromosome inactivation (XCI) is the phenomenon that has been selected during the evolution to balance X-linked gene dosage between XX females and XY...

X chromosome inactivation. The name Tsix comes from the reverse of Xist, which stands for X-inactive specific transcript. Female mammals have two X chromosomes...

contain the abnormality. When X-inactivation is skewed, more than 50% of one X chromosome are becoming inactive, and if that X-chromosome is passed to a male...

determined the Barr bodies were X chromosomes. In 1961, Mary Lyon proposed the concept of X-inactivation: when one of the two X chromosomes inside a female...

although they are generally less affected than males due to variability in X-inactivation. Large, protruding ears (both) Long face (vertical maxillary excess)...

different markings for their X inactivation. Through histone methylation, there is genetic imprinting, so that the same X homolog stays inactivated through...

and short stature. X chromosomes in females undergo a process known as X inactivation. X inactivation is when one of the two X chromosomes in females...

autosomal imprinting and X chromosome inactivation. With contemporaries that included Mary Lyon FRS (who discovered X chromosome inactivation), Bruce’s research...

Trisomy X include incomplete X-chromosome inactivation, and corresponding changes to DNA methylation and gene expression across the entire genome. X-inactivation...

X chromosomes is permanently inactivated in nearly all somatic cells (cells other than egg and sperm cells). This phenomenon is called X-inactivation...

The difference in hair coloration between CC and Rainbow is due to X-inactivation and epigenetic re-programming, which normally occurs in a fertilized...

a female with a X-linked recessive abnormality to have clinical symptoms: one is a manifesting carrier and the other is X-inactivation. A manifesting carrier...

biology, in particular focussing on X-chromosome inactivation, which occurs when one of the two copies of the X chromosomes in female mammals is inactivated...

phenotype is usually similar to Turner syndrome (45,X0) due to a lack of X inactivation. The typical medical treatment is hormone replacement therapy. The syndrome...

Medical Institute Investigator. She is known for her work on X-chromosome inactivation and for discovering the functions of a new class of epigenetic...

His interests are in the molecular basis of X-inactivation, the process that evolved in mammals to equalise X chromosome gene expression levels in XX females...

in females, with two X chromosomes, undergo X-inactivation, in which one of the two X chromosomes is inactivated. The inactivated X chromosome remains within...