The zone of polarizing activity (ZPA) is an area of mesenchyme that contains signals which instruct the developing limb bud to form along the anterior/posterior...

called the ZRS (zone of polarizing region activity regulatory sequence) that is located approximately 1 Mb upstream of the coding sequence of Shh." Devonian...

mesenchyme—including the zone of polarizing activity (ZPA)—continue to communicate with each other to direct further limb development. The position of the limb bud...

expression of SHH is seen on the anterior side of the limb. Normally SHH is expressed in an organiser region, called the zone of polarizing activity (ZPA)...

the zone of polarizing activity (ZPA) with the mesenchymal cells. In addition to the dorsal-ventral axis created by the ectodermal expression of competitive...

(AER) and the zone of polarizing activity (ZPA) with the mesenchymal cells. These signaling centers are crucial to the proper formation of a limb that is...

using chicken embryos, such as the discovery of the apical ectodermal ridge and the zone of polarizing activity. The chicken was the first bird species to...

digits depends on the secretion of sonic hedgehog by the zone of polarizing activity, located on the posterior side of the embryonic limb bud. Mutations...

of Polarizing Activity (ZPA) at the rear part of the AER coordinates the differentiation of digits. Anatomical terms of location Anatomical terms of motion...

1Mb upstream of SHH gene has been implicated. Normally SHH is expressed in an organiser region, called the zone of polarizing activity (ZPA) on the posterior...

associated with DNA mutations in the Zone of Polarizing Activity Regulatory Sequence (ZRS), a regulatory region of the sonic hedgehog gene which is critically...

generation of the hand (digits - interdigits): the gradient of sonic hedgehog (secreted inducing factor) from the zone of polarizing activity in the limb...

found in the zone of polarizing activity regulatory sequence, or ZRS, that controls the expression of SHH in developing limbs. Many cases of polysyndactyly...

they help an enhancer called ZRS (zone of polarizing activity regulatory sequence), which is found in intron 5 of the LMBR1 gene, interact with the Sonic...

of bird digits as I, II, III (as in their theropod ancestors) due to the posterior finger's development outside the shh-expressing zone of polarizing...

diffusible factor produced by the zone of polarizing activity (ZPA), a small region of tissue at the posterior margin of the limb. Mammalian development appeared...

Ultimately, TBX4 and TBX5 lead to the development of apical ectodermal ridge (AER) and zone of polarizing activity (ZPA) signaling centers in the developing limb...

Ultimately, Tbx5 leads to the development of apical ectodermal ridge (AER) and zone of polarizing activity (ZPA) signaling centers in the developing limb...

morphogenesis of limb buds have been focused on one particular axis of limb bud. However it has long been noted that zone of polarizing activity (ZPA) requires...

the expression of Sonic Hedgehog (SHh) to the posterior mesenchyme, which will eventually give rise to the Zone of Polarizing Activity (ZPA). This gene...

Ultimately, Tbx4 leads to the development of apical ectodermal ridge (AER) and zone of polarizing activity (ZPA) signaling centers in the developing limb...

Under the AEC, the nerves near the site of the limb destroyed are degraded. The AEC causes the progress zone to re-establish; this means the cells under...

an important role in the development or outgrowth of a limb along with the zone of polarizing activity(ZPA). Using these findings, Tickle focused her research...

patterning of these regions. The Zone of polarizing activity (ZPA) in the limb bud has pattern-organizing activity through the utilization of a morphogen...

(shh) signaling in the limb buds of embryos. The zone of polarizing activity (ZPA) in the proximal posterior mesoderm of a tetrapod limb bud is responsible...

Gasseling, studied the zone of polarizing activity (ZPA) and they were essential in identifying its role in the development of chick embryos. Saunders...

within the convective zone of the star. The convective circulation of the conducting plasma functions like a dynamo. This activity destroys the star's primordial...

Alex Ben (August 2, 2013). "Bethenny Frankel on Her New Show, Being 'Polarizing' and Why She's Reducing the Sex Talk". The Hollywood Reporter. Retrieved...

regions of the germinal center: the light zone (LZ) and the dark zone (DZ). These two zones are formed from pre-GC B cells that proliferate and polarize seven...

function of transition zone. Inherited defects in components of the transition zone cause ciliopathies, such as Joubert syndrome. Transition zone structure...