• Allele frequency, or gene frequency, is the relative frequency of an allele (variant of a gene) at a particular locus in a population, expressed as a...
    8 KB (1,089 words) - 18:09, 12 April 2024
  • Minor allele frequency (MAF) is the frequency at which the second most common allele occurs in a given population. They play a surprising role in heritability...
    3 KB (357 words) - 22:42, 4 March 2022
  • population genetics, the allele frequency spectrum, sometimes called the site frequency spectrum, is the distribution of the allele frequencies of a given set of...
    12 KB (1,573 words) - 04:51, 1 December 2023
  • Thumbnail for Hardy–Weinberg principle
    Hardy–Weinberg equilibrium, model, theorem, or law, states that allele and genotype frequencies in a population will remain constant from generation to generation...
    40 KB (5,950 words) - 17:28, 27 November 2023
  • allelic drift or the Wright effect, is the change in the frequency of an existing gene variant (allele) in a population due to random chance. Genetic drift...
    53 KB (6,352 words) - 16:09, 7 May 2024
  • heterozygote with two different "A" alleles.) The frequency of alleles in a diploid population can be used to predict the frequencies of the corresponding genotypes...
    17 KB (1,908 words) - 12:26, 28 April 2024
  • Thumbnail for Genotype frequency
    quantified by the frequency of alleles. Two fundamental calculations are central to population genetics: allele frequencies and genotype frequencies. Genotype...
    5 KB (765 words) - 04:09, 14 March 2022
  • focuses only on the change in frequency of alleles within populations. The main processes influencing allele frequencies are natural selection, genetic...
    61 KB (6,975 words) - 21:27, 20 April 2024
  • DNA (alleles) at different positions on the chromosome (loci) in a given population based on a comparison between the frequency at which two alleles are...
    25 KB (3,537 words) - 05:08, 2 May 2024
  • The Allele Frequency Net Database (abbreviated AlFreD) is a database containing the allele frequencies of immune genes and their corresponding alleles in...
    1 KB (77 words) - 15:18, 15 March 2023
  • Thumbnail for Genetic distance
    be present only in the isolated population. Random fluctuation of allele frequencies also produces genetic differentiation between populations. This process...
    38 KB (4,666 words) - 08:44, 6 May 2024
  • work described fitness as a function of allele frequencies. Here, each dimension describes an allele frequency at a different gene, and goes between 0...
    17 KB (1,959 words) - 13:41, 2 December 2023
  • Thumbnail for Genome-wide association study
    the allele frequency in the case group is much higher than in the control group, the odds ratio is higher than 1, and vice versa for lower allele frequency...
    68 KB (6,723 words) - 23:12, 23 May 2024
  • Thumbnail for Wahlund effect
    subpopulations are in a Hardy–Weinberg equilibrium but have different allele frequencies, the overall heterozygosity is reduced compared to if the whole population...
    4 KB (491 words) - 03:33, 20 May 2024
  • Thumbnail for Human leukocyte antigen
    the allele frequencies of HLA-I and HLA-II genes for the European population has been compiled. In both cases the distribution of allele frequencies reveals...
    51 KB (5,941 words) - 01:45, 20 March 2024
  • Thumbnail for Directional selection
    allele frequency to shift toward the chosen extreme over time as allele ratios change from generation to generation. The advantageous extreme allele will...
    22 KB (2,555 words) - 17:09, 9 May 2024
  • Thumbnail for HLA-DQ8
    HLA-DQ8 (section Alleles)
    Diabetes. Allele Query Form IMGT/HLA - European Bioinformatics Institute Middleton D, Menchaca L, Rood H, Komerofsky R (2003). "New allele frequency database:...
    66 KB (5,452 words) - 18:32, 3 December 2023
  • Thumbnail for Single-nucleotide polymorphism
    age at onset of the disease. Single nucleotide substitutions with an allele frequency of less than 1% are sometimes called single-nucleotide variants (SNVs)...
    57 KB (6,149 words) - 04:35, 17 May 2024
  • Thumbnail for Quantitative genetics
    particular biochemical. Both of these branches of genetics use the frequencies of different alleles of a gene in breeding populations (gamodemes), and combine...
    158 KB (21,655 words) - 05:49, 7 March 2024
  • Thumbnail for CCR5
    gradient of allele frequency in Europe, which shows that the highest allele frequency occurred in the Nordic countries and lowest allele frequency in southern...
    67 KB (7,844 words) - 14:24, 25 March 2024
  • Thumbnail for HLA-A*02
    HLA-A*02 (category HLA-A alleles)
    contributed the Cw5 allele to the haplotype. The haplotype appears to have been introduced early in European prehistoric period, frequencies of the haplotype...
    31 KB (1,695 words) - 23:27, 8 December 2023
  • Number=A,Type=Float,Description="Allele Frequency"> ##INFO=<ID=AA,Number=1,Type=String,Description="Ancestral Allele"> ##INFO=<ID=DB,Number=0,Type=Flag...
    13 KB (1,026 words) - 10:14, 23 May 2024
  • allele of the eye-color gene produces blue eyes and another allele of the eye-color gene produces brown eyes. allele frequency The relative frequency...
    144 KB (15,393 words) - 06:54, 23 February 2024
  • also called genetic draft or the hitchhiking effect, is when an allele changes frequency not because it itself is under natural selection, but because it...
    10 KB (1,276 words) - 04:41, 24 May 2024
  • Thumbnail for Fixed allele
    population genetics, a fixed allele is an allele that is the only variant that exists for that gene in a population. A fixed allele is homozygous for all members...
    15 KB (1,740 words) - 21:32, 14 April 2024
  • Frequency-dependent selection can also lead to dynamical chaos when some individuals' fitnesses become very low at intermediate allele frequencies. The...
    12 KB (1,396 words) - 06:26, 4 January 2024
  • Thumbnail for Apolipoprotein E
    every population. Nigerian people have the highest observed frequency of the APOE4 allele in world populations, but AD is rare among them. This may be...
    58 KB (6,460 words) - 12:18, 6 May 2024
  • Thumbnail for Allopurinol
    (TEN). The frequency of the HLA-B*5801 allele varies between ethnicities: Han Chinese and Thai populations have HLA-B*5801 allele frequencies of around...
    29 KB (2,755 words) - 17:54, 16 May 2024
  • Microevolution is the change in allele frequencies that occurs over time within a population. This change is due to four different processes: mutation...
    39 KB (4,750 words) - 13:32, 28 February 2024
  • Thumbnail for DbSNP
    false positive rate between 15-17% for SNPs, and also that the minor allele frequency is greater than 10% for approximately 80% of the SNPs that are not...
    21 KB (2,140 words) - 21:38, 2 December 2023