division control protein 42 homolog (Cdc42 or CDC42) is a protein that in humans is encoded by the CDC42 gene. Cdc42 is involved in regulation of the cell...
31 KB (3,698 words) - 21:38, 25 March 2024
Dendritic spine (section Cdc42 pathway)
of the spine, and actin regulators, small GTPases such as Rac, RhoA, and CDC42, rapidly modify this cytoskeleton. Overactive Rac1 results in consistently...
48 KB (5,682 words) - 20:19, 21 January 2024
CDC42 binding protein kinase beta is a protein that in humans is encoded by the CDC42BPB gene. This gene encodes a member of the serine/threonine protein...
2 KB (353 words) - 05:20, 27 March 2022
CDC42 effector protein 5 is a protein that in humans is encoded by the CDC42EP5 gene. Cell division control protein 42 (CDC42), a small Rho GTPase, regulates...
1 KB (194 words) - 06:01, 6 December 2022
and some plants. Three members of the family have been studied in detail: Cdc42, Rac1, and RhoA. All G proteins are "molecular switches", and Rho proteins...
25 KB (3,190 words) - 17:03, 24 August 2023
pathways blocked. CDC42 is a small, Rho family GTPase involved in the pinching off and remodeling of the cellular plasma membrane. CDC42-regulated dynamin...
18 KB (2,003 words) - 19:31, 28 April 2024
PAK1 (redirect from P21/Cdc42/Rac1-activated kinase 1)
human PAK1 was identified as a GTP-dependent interacting partner of Rac1 or Cdc42 in the cytosolic fraction from neutrophils, and its complementary DNA was...
43 KB (5,251 words) - 02:22, 8 April 2024
(GEF) that specifically activates Cdc42, a member of the Rho (Ras homology) family of the p21 GTPases. By activating Cdc42, FGD1 protein stimulates fibroblasts...
11 KB (1,054 words) - 12:58, 28 July 2023
binding to a region near its N-terminus. Its activation is dependent upon CDC42 and PIP2 acting to disrupt this interaction, causing the WASp protein to...
21 KB (2,588 words) - 00:21, 5 February 2024
membrane and, thus, epithelial polarity. These molecules are the proteins Cdc42, atypical protein kinase C (aPKC), Par6, Par3/Bazooka/ASIP. Crumbs, "Stardust"...
10 KB (1,305 words) - 22:43, 4 February 2024
Cdc42 effector protein 3 is a protein that in humans is encoded by the CDC42EP3 gene. CDC42, a small Rho GTPase, regulates the formation of F-actin-containing...
7 KB (872 words) - 20:58, 3 March 2023
Cdc42 effector protein 2 is a protein that in humans is encoded by the CDC42EP2 gene. CDC42, a small Rho GTPase, regulates the formation of F-actin-containing...
4 KB (493 words) - 10:13, 10 January 2024
and Cdc42 are two Rho-family GTPases which are normally cytosolic but can also be found in the cell membrane under certain conditions. When Cdc42 is activated...
8 KB (775 words) - 22:38, 1 February 2024
Rho-type GTPase Cdc42. Specifically, Orb6 kinase spatially restricts Cdc42 activation to be at the polarized tips of a cell, causing the Cdc42-dependent formins...
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RAC/CDC42 exchange factor, also known as GEFT, is a human gene. GEFT has been shown to interact with RHOA. GRCh38: Ensembl release 89: ENSG00000240771...
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globally by depleting them. The master regulator of polarity in yeast is Cdc42, which is a member of the eukaryotic Ras-homologous Rho-family of GTPases...
19 KB (2,430 words) - 20:56, 3 December 2023
cip/kip (p21, p27, p57) P53 p63 p73 family p53 p63 p73 Other Cdc2 Cdc25 Cdc42 Cellular apoptosis susceptibility protein E2F Maturation promoting factor...
38 KB (4,256 words) - 14:44, 16 May 2024
Cdc42-interacting protein 4 is a protein that in humans is encoded by the TRIP10 gene. TRIP10 has been shown to interact with STAT3, Wiskott-Aldrich syndrome...
9 KB (1,158 words) - 16:50, 28 January 2023
G protein-coupled receptors, which activate GTPases of the Rho family (e.g. Cdc42, Rac) via G proteins. Rho GTPases are able to activate WASp which in turn...
16 KB (1,747 words) - 18:27, 11 March 2024
signal transduction events resulting in the recruitment of Arp2/3 complex. CDC42, protein tyrosine kinase, phosphoinositide 3-kinase, and Src-family kinases...
34 KB (4,063 words) - 20:08, 22 May 2024
and GEECs comprise the Cdc42-mediated CLIC/GEEC endocytic pathway, which is regulated by GRAF1. Each of RhoA, Arf6, or Cdc42 has the capacity to modulate...
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targets Rho, Rac, and Cdc42. These molecules are important regulators of cell signaling. Small GTPases such as Rho, Rac, and Cdc42 regulate their activity...
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influence other endocytic pathways. When CAV1 binds to Cdc42, CAV1 inactivates it and regulates Cdc42 activity during membrane trafficking events. The process...
25 KB (2,972 words) - 01:47, 11 May 2024
subfamily J, member 2 (17q24.3) ACTG1: actin, gamma 1 (17q25) CDC42EP4: CDC42 effector protein 4 (17q25.1) USH1G: Usher syndrome 1G (autosomal recessive)...
26 KB (1,920 words) - 22:52, 28 March 2024
Cdc42 effector protein 4 is a protein that in humans is encoded by the CDC42EP4 gene. The product of this gene is a member of the CDC42-binding protein...
4 KB (536 words) - 01:42, 3 December 2023
Semaphorin/plexin-neuropilin, slit-robo, netrin-frazzled, reelin. Rac, CDC42 and RhoA serve as cytoskeletal regulators and the motor protein includes...
24 KB (2,826 words) - 19:32, 26 April 2024
protein (GAP) for CDC42 (MIM 116952) and regulates the ARP2/3 complex (MIM 604221) and F-actin dynamics at the Golgi through control of CDC42 activity (Dubois...
5 KB (710 words) - 08:58, 18 August 2023
autoinhibition by a smaller ligand (such as Ras for c-Raf, GADD45 for MEKK4 or Cdc42 for MLK3). This commonly (but not always) happens at the cell membrane,...
46 KB (5,509 words) - 06:42, 23 May 2024
Cdc42 effector protein 1 is a protein that in humans is encoded by the CDC42EP1 gene. CDC42 is a member of the Rho GTPase family that regulates multiple...
8 KB (695 words) - 01:42, 3 December 2023
Activated CDC42 kinase 1, also known as ACK1, is an enzyme that in humans is encoded by the TNK2 gene. TNK2 gene encodes a non-receptor tyrosine kinase...
14 KB (1,756 words) - 21:43, 7 November 2023